Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 6, 1999, Pages 1261-1265

  Sullivan, David A ^a   Krenzer, Kathleen L ^a,c   Sullivan, Benjamin D ^a   Tolls, Dorothy Bazzinotti ^c   Toda, Ikuko ^a   Dana, M Reza ^a,b  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NEW ENGLAND COLLEGE OF OPTOMETRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DRY EYE; FEMALE; GUINEA PIG; HISTOPATHOLOGY; HORMONE DEFICIENCY; HORMONE INHIBITION; HUMAN; IMAGE ANALYSIS; LACRIMAL GLAND DISEASE; LACRIMATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RABBIT; RAT; SCHIRMER TEST; SJOEGREN SYNDROME;

AGED; AGED, 80 AND OVER; ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; FEMALE; FEMINIZATION; HUMANS; HYPOPHYSECTOMY; INFLAMMATION; LACRIMAL APPARATUS; LACRIMAL APPARATUS DISEASES; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; ORCHIECTOMY; OVARIECTOMY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; REFERENCE VALUES; TEARS;

EID: 0032925486     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Sullivan DA, Wickham LA, Rocha EM, Kelleher RS, Silveira LA, Toda I. Influence of gender, sex steroid hormones and the hypothalamic-pituitary axis on the structure and function of the lacrimal gland. Adv Exp Med Biol. 1998;438:11-42.
2. Sullivan DA, Wickham LA, Krenzer KL, Rocha EM, Toda I. Aqueous tear deficiency in Sjögren's syndrome: possible causes and potential treatment. In: Pleyer U, Hartmann C, Sterry W, eds. Oculodermal Diseases: Immunology of Bullous Oculo-Muco-Cutaneous Disorders. Buren, The Netherlands: Aeolus Press; 1997:95-152.
3. Sullivan DA. Sex hormones and Sjögren's syndrome. J Rheumatol. 1997;24(suppl):17-32.
4. Mircheff AK. Understanding the causes of lacrimal insufficiency: implications for treatment and prevention of dry eye syndrome. In: Research to Prevent Blindness Science Writers Seminar. New York: Research to Prevent Blindness; 1993:51-54.
5. Azzarolo AM, Mircheff AK, Kaswan RL, et al. Androgen support of lacrimal gland function. Endocrine. 1997;6:39-45.
6. Azzarolo AM, Wood RL, Mircheff AK, et al. Time course of apoptosis in lacrimal gland after rabbit ovariectomy. Adv Exp Med Biol. 1998;438:523-526.
7. Warren DW, Azzarolo AM, Huang ZM, et al. Androgen support of lacrimal gland function in the female rabbit. Adv Exp Med Biol. 1998;438:89-93.
8. He WW, Kumar MV, Tindall DJ. A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res. 1991;19:2373-2378.
9. Sullivan DA, Block L, Pena JDO. Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland. Acta Ophthalmol Scand. 1996;74:421-435.
10. Murphy L, O'Shaughnessy PJ. Testicular steroidogenesis in the testicular feminized (Tfm) mouse loss of 17 α-hydroxylase activity. J Endocrinol. 1991;131:443-449.
11. Sullivan DA, Rocha EM, Ullman MD, et al. Androgen regulation of the meibomian gland. Adv Exp Med Biol. 1998;438:327-331.
12. Tsubota K. SS dry eye and non-SS dry eye: what are the differences? In: Homma M, Sugai S, Tojo T, Miyasaka N, Akizuki M, eds. Sjögren's Syndrome: State of the Art. Amsterdam: Kugler Press; 1994:27-31.