Effect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats

Brazilian Journal of Medical and Biological Research

Volumn 32, Issue 4, 1999, Pages 431-434

  Bucaretchi, F ^a   Vinagre, A M ^a   Chavez Olortegui C ^b   Collares, E F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

Author keywords

Gastric emptying; Tityus serrulatus scorpion venom; Toxin

Indexed keywords

TITYUS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENVENOMATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; RAT; STOMACH ACID SECRETION; STOMACH EMPTYING; STOMACH MOTILITY;

ANIMALIA; RATTUS NORVEGICUS; SCORPIONES; TITYUS; TITYUS SERRULATUS;

EID: 0032925181     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1999000400009     Document Type: Article

References (21)

1. Freire-Maia L & Campos JA (1989). Pathophysiology and treatment of scorpion poisoning. In: Ownby CH & Odell GV (Editors), Natural Toxins. Pergamon Press, Oxford, 139-159.
2. Bucaretchi F, Baracat ECE, Nogueira RJN, Chaves A, Zambrone FAD, Fonseca MRC & Tourinho FS (1995). A comparative study of severe scorpion envenomation in children caused by Tityus bahiensis and Tityus serrulatus. Revista do Instituto de Medicina Tropical de Sāo Paulo, 37: 331-336.
3. Andrade SP, Santos RAS & Beraldo WT (1981). Comparative study of the action of purified scorpion toxin (tityustoxin) on the submandibular and parotid glands of the rat. Toxicon, 19: 255-261.
4. Cunha-Melo JR, Gonzaga HMS, Alzamora F & Freire-Maia L (1983). Effects of purified scorpion toxin (tityustoxin) on gastric secretion in the rat. Toxicon, 21: 843-848.
5. Cunha-Melo JR, Almeida AP, Gonzaga HMS, Gomez MV & Freire-Maia L (1987). Effect of scorpion toxin on gastric histamine and acetylcholine content in the rat. Brazilian Journal of Medical and Biological Research, 20: 393-401.
6. Novaes G, Cabral APG, Falco CNML & Queiroz AC (1989). Acute pancreatitis induced by scorpion toxin, tityustoxin. Histopathological study in rats. Arquivos de Gastroenterologia de Sāo Paulo, 26: 9-12.
7. Cunha-Melo JR, Toppa NH, Martins P, Colares CN, Castro CN & Freire-Maia L (1991). Acute gastric injury induced by toxins from Tityus serrulatus scorpion venom: a novel experimental model in the rat. Toxicon, 29: 1395-1401.
8. Hunt JN (1983). Mechanisms and disorders of gastric emptying. Annual Review in Medicine, 34: 219-229.
9. Roman C & Gonella J (1987). Extrinsic control of the stomach. In: Johnson LR (Editor), Physiology of the Gastrointestinal Tract. 2nd edn. Raven Press, New York, 522-532.
10. Sampaio SV, Laure CJ & Giglio JR (1983). Isolation and characterization of toxic proteins from the venom of the Brazilian scorpion Tityus serrulatus. Toxicon, 21: 265-277.
11. Belangero VMS & Collares EF (1991). Estudo do esvaziamento gástrico e acidose metabólica. I. Estudo de um modelo experimental em ratos, empregando uma soluçāo de cloreto de amônio por via orogástrica. Arquivos de Gastroenterologia de Sāo Paulo, 28: 145-150.
12. Bucaretchi F & Collares EF (1996). Effect of Phoneutria nigriventer spider venom on gastric emptying in rats. Brazilian Journal of Medical and Biological Research, 29: 205-211.
13. Burks TF (1987). Actions of drugs on gastrointestinal motility. In: Johnson LR (Editor), Physiology of the Gastrointestinal Tract. 2nd edn. Raven Press, New York, 723-743.
14. Rees MR, Clark RA & Holdsworth CD (1980). The effect of beta-adrenoceptor agonists on gastric emptying in man. British Journal of Clinical Pharmacology, 10: 551-554.
15. Sofer S, Cohen R, Shapir Y, Chen L, Colon A & Sharf SM (1997). Scorpion venom leads to gastrointestinal ischemia despite increased oxygen delivery in pigs. Critical Care Medicine, 25: 834-840.
16. Gwee MCE, Cheah LS & Gopalakrishnakone P (1985). Involvement of the L-arginine-nitric-oxide synthase pathway in the relaxant responses of the rat isolated anococcygeus muscle to a scorpion (Leiurus quinquestriatus quinquestriatus) venom. Toxicon, 33: 1141-1150.
17. Teixeira CE, Bento AC, Lopes-Martins RAB, Teixeira SA, Von Eicstedt V, Muscará MN, Arantes EC, Giglio JR, Antunes E & De Nucci G (1998). Effect of Tityus serrulatus scorpion venom on the rabbit isolated corpus cavernosum and the involvement of NANC nitrergic nerve fibres. British Journal of Pharmacology, 123: 435-442.
18. Chou CC (1982). Relationship between intestinal blood flow and motility. Annual Review of Physiology, 44: 29-42.
19. Stark ME & Szurszewski JH (1992). Role of nitric oxide in gastrointestinal function and disease. Gastroenterology, 103: 1928-1949.
20. Troncon LEA, Garbacio VL, Santos A, Secaf M & Cunha-Melo JR (1996). Efeitos da toxina escorpiônica sobre o esvaziamento gástrico em ratos. In: Annals of the XI Reuniāo da Federaçāo das Sociedades de Biologia Experimental, Caxambu, 21-24 August, Abstract 09.005, 72.
21. Barhanin J, Ildefonse M, Rougier O, Sampaio SV, Giglio JR & Lazdunski M (1982). Tityus γ toxin, a high affinity effector of the sodium channel in muscle with a selectivity for channels in the surface membrane. Pflügers Archives, 400: 22-27.