Modification of the expression of naloxone-precipitated withdrawal signs in morphine-dependent mice by diabetes: Possible involvement of protein kinase C

Japanese Journal of Pharmacology

Volumn 79, Issue 3, 1999, Pages 303-311

  Ohsawa, Masahiro ^a   Kamei, Junzo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Diabetes; Morphine withdrawal; Noradrenaline turnover; Protein kinase A; Protein kinase C

Indexed keywords

CALPHOSTIN C; CYCLIC AMP DEPENDENT PROTEIN KINASE; KT 5720; MU OPIATE RECEPTOR; NALOXONE; NORADRENALIN; PHORBOL DIBUTYRATE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; FRONTAL CORTEX; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; JUMPING; MALE; MODULATION; MORPHINE ADDICTION; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

EID: 0032925020     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.303     Document Type: Article

References (51)

1. Cox BM: Drug tolerance and physical dependence. In Principles of Drug Action, Edited by Pratt WB and Taylor P, pp 639-690, Churchill Livingstone, New York (1990)
2. Nestler EJ: Molecular mechanisms of drug addiction. J Neurosci 12, 2439-2450 (1992)
3. Nestler EJ, Erdos JJ, Terwilliger R, Duman RS and Tallman JF: Regulation of G-proteins by chronic morphine treatment in the rat locus coeruleus. Brain Res 476, 230-239 (1989)
4. Sharma SK, Klee WA and Nirenberg M: Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc Natl Acad Sci USA 72, 2655-2660 (1975)
5. 2-Adrenoceptor-mediated inhibition of platelet adenylate cyclase activity in heroin addicts in abstinence. Psychopharmacology (Berl) 92, 320-323 (1987)
6. Escribá PV, Sastre M and García-Sevilla JA: Increased density of guanine nucleotide-binding proteins in the frontal cortex of heroin addicts. Arch Gen Psychiatry 51, 494-501 (1994)
7. Parolaro D, Rubino T, Gori P, Massi P, Bendotti C, Patrini G, Marcozzi C and Parenti M: In situ hybridization reveals specific increase in Gαs and Gαo mRNA in discrete brain regions of morphine-tolerant rats. Eur J Pharmacol 244, 211-222 (1993)
8. Nestler EJ and Tallman JF: Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus. Mol Pharmacol 33, 127-132 (1988)
9. Terwilliger RZ, Beitner-Johnson D, Sevarino KA, Crain SM and Nestler EJ: A general role for adaptation in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 548, 100-110 (1991)
10. Matsuoka I, Maldonado R, Defer N, Noel F, Hanoune J and Roques BP: Chronic morphine administration causes region-specific increase of brain type VIII adenylyl cyclase mRNA. Eur J Pharmacol 268, 215-221 (1994)
11. Collier HOJ and Roy AC: Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate. Nature 248, 24-27 (1974)
12. Collier HOJ: Cellular site of opiate dependence. Nature 283, 625-629 (1980)
13. Mayer DJ, Mao J and Price DD: The development of morphine tolerance and dependence is associated with translocation of protein kinase C. Pain 61, 365-374 (1995)
14. Narita M, Feng Y, Makimura M, Hoskins B and Ho IK: Repeated administration of opioids alters characteristics of membrane-bound phorbol ester binding in rat brain. Eur J Pharmacol 271, 547-550 (1994)
15. Smart D and Lambert DG: The stimulatory effects of opioids and their possible role in the development of tolerance. Trends Pharmacol Sci 17, 264-296 (1996)
16. Maldonado R, Valverde O, Garbay C and Roques BP: Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal. Naunyn Schmiedebergs Arch Pharmacol 352, 565-575 (1995)
17. 2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. J Pharmacol Exp Ther 277, 484-490 (1996)
18. Busques X, Escribá PV, Sastre M and García-Sevilla JA: Loss of protein kinase C-αβ in brain of heroin addicts and morphine-dependent rats. J Neurochem 64, 247-252 (1995)
19. Makimura M, Iwai M, Sugimoto H and Fukuda H: Effect of NMDA receptor antagonists on protein kinase activated by chronic morphine treatment. J Toxicol Sci 22, 59-66 (1997)
20. Redmond DE and Krystal JH: Multiple mechanisms of withdrawal from opioid drugs. Annu Rev Neurosci 7, 443-478 (1984)
21. Aghajanian GK: Tolerance of locus coeruleus neurons to morphine and suppression of withdrawal response by clonidine. Nature 276, 186-188 (1978)
22. Crawley JN, Laverty R and Roth RH: Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal. Eur J Pharmacol 57, 247-250 (1979)
23. Rasmussen K and Aghajanian GK: Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: Attenuation by lesions of the nucleus paragigantocelluaris. Brain Res 505, 346-350 (1989)
24. Craven PA and De Rubertis FR: Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. J Clin Invest 83, 1667-1675 (1989)
25. King GL, Johnson S and Wu G: Possible growth modulators involved in the pathogenesis of diabetic proliferate retinopathy. In Growth Factors in Health and Diseases, Edited by Westermark B, Betscholtz C and Hokfelt T, pp 303-317, Elsevier Publishing Co, Amsterdam (1990)
26. Inoguchi T, Battan R, Handler E, Sportsman JR, Health W and King GL: Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89, 11059-11063 (1992)
27. Tanaka Y, Kashiwagi A, Ogawa T, Abe N, Asahina T, Ikebuchi M, Takagi Y and Shigeta Y: Effect of verapamil on cardiac protein kinase C activity in diabetic rats. Eur J Pharmacol 200, 353-356 (1991)
28. Wolf BA, Williamson JR, Easom RA, Chang K, Sherman WR and Turk J: Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels. J Clin Invest 98, 31-38 (1990)
29. Shiba T, Inoguchi T, Sportsman R, Health W, Bursell SE and King GL: Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol 265, E787-E793 (1993)
30. 5]enkephalin-induced antinociception in diabetic mice. Eur J Pharmacol 339, 27-31 (1997)
31. Khandelwal RL, Zinman SM and Zebrowski EJ: The effect of streptozotocin-induced diabetes and of insulin supplementation on glycogen metabolism in rat liver. Biochem J 168, 541-548 (1977)
32. Davies GF, Crosson SM, Khandelwal RL and Roesler WJ: The phosphorylation state of the cAMP response element binding protein is decreased in diabetic rat liver. Arch Biochem Biophys 323, 477-483 (1995)
33. Kamei J, Ohsawa M, Saitoh A, Iwamoto Y, Suzuki T, Misawa M, Nagase H and Kasuya Y: Modification of μ-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes. J Pharmacol Exp Ther 274, 700-706 (1995)
34. Kamei J and Ohsawa M: Role of noradrenergic functions in the modification of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes. Life Sci 60, PL223-PL228 (1997)
35. Maldonado R, Dauge V, Callebert J, Villette JM, Fournie-Zaluski MC, Feger J and Roques RB: Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome. Eur J Pharmacol 165, 199-207 (1989)
36. Haley MJ and McCormik WG: Pharmacological effects produced by intracerebral injections of drug in the conscious mice. Br J Pharmacol 12, 12-15 (1957)
37. Narita M, Ohsawa M, Mizoguchi H, Kamei J and Tseng LF: Pretreatment with protein kinase C activator phorbol-12,13-dibutyrate attenuates the antinociception induced by μ-but not ε-opioid receptor agonist in the mouse. Neuroscience 76, 291-298 (1997)
38. Duman RS, Tallman JF and Nestler EJ: Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus. J Pharmacol Exp Ther 246, 1033-1039 (1988)
39. Alreja M and Aghajanian GK: Pacemaker activity of locus coeruleus neurons: whole-cell recordings in brain slices show dependence on cAMP and protein kinase A. Brain Res 556, 339-343 (1991)
40. Kogan JH, Nestler EJ and Aghajanian GK: Elevated basal firing rates of locus coruleus neurons in brain slices from opiate-dependent rats: association with enhanced responses to 8-Br-cAMP. Eur J Pharmacol 211, 47-53 (1992)
41. Shiekhattar R and Aston-Jonse G: Modulation of opiate responses in brain noradrenergic neurons by the cyclic AMP cascade: changes with chronic morphine. Neuroscience 57, 879-885 (1993)
42. Rasmmussen K, Beitner DB, Krystal JH, Aghajanian GK and Nestler EJ: Opiate withdrawal and the rat locus coruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci 10, 2308-2317 (1990)
43. Tokuyama S, Zhu H, Wakabayashi H, Feng YZ and Ho IK: The role of glutamate in the locus coeruleus during opioid withdrawal and effects of H-7, a protein kinase inhibitor, on the action of glutamate in rats. J Biomed Sci 5, 45-53 (1997)
44. Shearman MS, Sekiguchi K and Nishizuka Y: Modulation of ion channel activity: a key function of the protein kinase C enzyme family. Pharmacol Rev 41, 211-237 (1989)
45. + channel. J Biol Chem 269, 7839-7842 (1994)
46. 3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function. J Pharmacol Exp Ther 244, 41-50 (1988)
47. Moran O and Dascal N: Protein kinase C modulates neurotransmitter responses in Xenopus oocytes injected with rat brain RNA. Brain Res Mol Brain Res 5, 193-202 (1989)
48. Corvera S and Garcia-Sainz JA: Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes. Biochem Biophys Res Commun 119, 1128-1133 (1984)
49. Sibley DR, Nambi P, Peters JR and Lefkowitz RJ: Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. Biochem Biophys Res Commun 121, 973-979 (1984)
50. Pellegrini-Giampietro DE, Ruggiero M, Giannelli S, Chiarugi VP and Moroni F: Morphine withdrawal in vitro: potentiation of agonist-dependent polyphosphoinositide breakdown. Eur J Pharmacol 149, 297-306 (1988)
51. Ventayol P, Busquets X and García-Sevilla JA: Modulation of immunoreactive protein kinase C-α and β isoforms and G proteins by acute and chronic treatments with morphine and other opiate drugs in rat brain. Naunyn Schmiedebergs Arch Pharmacol 355, 491-500 (1997)