Nitric oxide and penile erection in streptozotocin-diabetic rats

Clinical Science

Volumn 96, Issue 4, 1999, Pages 365-371

  Ari, Gil ^a   Vardi, Yoram ^b   Finberg, John P M ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Corpus cavernosum; Diabetic impotence; Nitric oxide; Penile erection; Streptozotocin

Indexed keywords

ARGININE; CITRULLINE; INSULIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COPULATION; CORPUS CAVERNOSUM; ELECTROSTIMULATION; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; ISOTOPE LABELING; MALE; NERVE STIMULATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SPINAL ROOT; STREPTOZOCIN DIABETES; SUBCUTANEOUS DRUG ADMINISTRATION; VASODILATATION;

EID: 0032924356     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0960365     Document Type: Article

References (26)

1. 1 Steger, R. W., Amador, A., Lam, E., Rathert, J., Weis, J. and Smith, M. S. (1989) Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats. Endocrinology 124, 1737-1743
2. 2 Hassan, A. A., Hassouna, M. M., Taketo, T., Gagnon, C. and Elhilai, M. M. (1993) The effect of diabetes on sexual behavior and reproductive tract function in male rats. J. Urol. 149, 148-154
3. 3 Elabbady, A. A., Gagnon, C., Hassouna, M. M., Begin, L. R. and Elhilai, M. M. (1995) Diabetes mellitus increases nitric oxide synthase in penises but not in major pelvic ganglia of rats. Br. J. Urol. 76, 196-202
4. 4 Sachs, B. D., Baum, M. J. and Melman, A. (1982) Normal sexual behavior and penile reflexes in long-term diabetic male rats. Arch. Androl. 9, 351-353
5. 5 Steers, W. D., Mackway, A. M. and DeGroat, W. C. (1991) Electrophysiological properties of the cavernous nerve in the streptozotocin diabetic rat. Int. J. Impotence Res. 3, 197-202
6. 6 Italiano, G., Marin, A., Pescatori, E. S. et al. (1993) Effect of streptozotocin-induced diabetes on electrically evoked erection in the rat. Int. J. Impotence Res. 5, 27-35
7. 7 Tomlinson, K. C., Gardiner, S. M., Hebden, R. A. and Bennett, T. (1992) Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol. Rev. 44, 103-150
8. 8 Vardi, Y., Youdim, M. B. H., Levin, R. D. and Finberg, J. P. M. (1989) A model for the study of penile erection in the rat. Int. J. Impotence Res. 1, 11-15
9. 9 Finberg, J. P. M., Levy, S. and Vardi, Y. (1993) Inhibition of nerve stimulation-induced vasodilatation in rat corpora cavernosa by blockade of nitric oxide synthase. Br. J. Pharmacol. 108, 1038-1042
10. 10 Steger, R. W. and Kienast, S. G. (1990) Effect of continuous versus delayed insulin replacement on sex behavior and neuroendocrine function in diabetic male rats. Diabetes 39, 942-948
11. 11 Dewsbury, D. A. (1967) A quantitative description of the behaviour of rats during copulation. Behaviour 29, 154-160
12. 12 Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R. and Snyder, S. H. (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (London) 351, 714-718
13. 13 Heygate, K. M., Davies, J., Holmes, M., James, R. F. L. and Thurston, H. (1996) The effect of insulin treatment and of islet transplantation on the resistance artery function in the STZ-induced diabetic rat. Br. J. Pharmacol. 19, 495-504
14. 14 Greene, D. A., De Jesus, P. V. and Winegrad, A. I. (1975) Effects of insulin and dietary myo-inositol on impaired peripheral motor conduction velocity in acute streptozotocin diabetes. J. Clin. Invest. 55, 1326-1336
15. 15 Murzi, E., Contreras, Q., Teneud, L. et al. (1996) Diabetes decreases limbic extracellular dopamine in rats. Neurosci. Lett. 202, 141-144
16. 16 Tomlinson, D. R. and Mayer, J. H. (1984) Defects of axonal transport in diabetes mellitus : a possible contribution to the etiology of diabetic neuropathy. J. Auton. Pharmacol. 4, 59-72
17. 17 Cameron, N. E., Cotter, M. A. and Low, P. A. (1991) Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits. Am. J. Physiol. 261, E1-E8
18. 18 Ari, G. (1996) Effects of diabetes on function of the autonomic nervous system in penile erection. Ph.D. Thesis, Technion, Israel Institute of Technology, Israel
19. 19 Jaap, A. J. and Tooke, J. E. (1995) Pathophysiology of microvascular disease in non-insulin-dependent diabetes. Clin. Sci. 89, 3-12
20. 20 McNally, P. G., Watt, P. A. C., Rimmer, T., Burden, A. C., Hearnshaw, J. R. and Thurston, H. (1994) Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clin. Sci. 87, 31-36
21. 21 Taylor, P. D., Oon, B. B., Thomas, C. R. and Poston, L. (1994) Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline-induced contractility in mesenteric resistance arteries from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 111, 35-41
22. 22 Furman, F. and Sneddon, P. (1993) Endothelium-dependent vasodilator responses of the isolated mesenteric bed are preserved in long-term streptozotocin diabetic rats. Eur. J. Pharmacol. 232, 29-34
23. 2. Am. J. Physiol. 277, H1327-H1333
24. 24 Walker, A. B., Savage, M. W., Dores, J. and Williams, G. (1997) Insulin-induced attenuation of noradrenaline-mediated vasoconstriction in resistance arteries from Wistar rats is nitric oxide dependent. Clin. Sci. 92, 147-152
25. 25 McNally, P. G., Lawrence, I. G., Watt, P. A. C., Hillier, C., Burden, A. C. and Thurston, H. (1995) The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers. Diabetologia 38, 467-473
26. 26 Vernet, D., Cai, L. P., Garban, H. et al. (1995) Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction. Endocrinology 136, 5709-5717