Tranilast inhibits the proliferation of human coronary smooth muscle cell through the activation of p21(waf1)

Atherosclerosis

Volumn 143, Issue 2, 1999, Pages 307-313

  Kusama, Hiroshi ^a   Kikuchi, Shinji ^a   Tazawa, Shigeki ^a   Katsuno, Kenji ^a   Baba, Yoshifumi ^a   Zhai, Ya Li ^b   Nikaido, Toshio ^b   Fujii, Shingo ^c  

^a Kissei Pharmaceutical Company Limited   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

CDK; P21(waf1); P53; Proliferation; PTCA; Smooth muscle cell; Tranilast

Indexed keywords

PROTEIN P21; TRANILAST;

ARTICLE; CELL PROLIFERATION; CORONARY ARTERY ATHEROSCLEROSIS; DRUG EFFECT; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; TRANSLUMINAL CORONARY ANGIOPLASTY; VASCULAR SMOOTH MUSCLE;

EID: 0032923976     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00308-6     Document Type: Article

References (18)

1. Glagov S. Intimal hyperplasia, vascular modeling, and the restenosis problem. Circulation. 89:1994;2888-2891.
2. Liu M.W., Roubin G.S., King S.B. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation. 79:1989;1374-1387.
3. Azuma H., Banno K., Yoshimura T. Pharmacological properties of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′), a new anti-atopic agent. Br. J. Pharmacol. 58:1976;483-488.
4. Isaji M., Nakajoh M., Naito J. Selective inhibition of collagen accumulation by N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′) in granulation tissue. Biochem. Pharmacol. 36:1987;469-474.
5. Kato K., Tamai H., Hayakawa H., Yamaguchi T., Kanmatsuse K., Haze K., Aizawa T., Suzuki S., Takase S., Suzuki T., Nishikawa H., Nakanishi S., Kato O., Nakashima M. Clinical evaluation of tranilast on restenosis after percutaneous transluminal coronary angioplasty (PTCA). A double-blind placebo-controlled comparative study. Rinsyou. Iyaku. 12:1996;65-85.
6. Miyazawa K., Kikuchi S., Fukuyama J., Hamano S., Ujiie A. Inhibition of PDGF and TGF-β1-induced collagen synthesis, migration and proliferation by tranilast in vascular smooth muscle cells from spontaneously hypertensive rats. Atherosclerosis. 118:1995;213-221.
7. Fukuyama J., Miyazawa K., Hamano S., Ujiie A. Inhibitory effects of tranilast on proliferation, migration and collagen synthesis of human vascular smooth muscle cells. Can. J. Pharmacol. 74:1996;80-84.
8. Kikuchi S., Umemura K., Kondo K., Nakashima M. Tranilast suppresses intimal hyperplasia after photochemically induced endothelial injury in the rat. Eur. J. Pharmacol. 295:1996;221-227.
9. Kikuchi S., Umemura K., Kondo K., Saniabadi A.R., Nakashima M. Photochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimal thicking. Arter. Throm. Vasc. Biology. 18:1998;1069-1078.
10. Morgan D.O. Principles of CDK regulation. Nature. 374:1995;131-134.
11. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
12. Peter M., Herskowitz I. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell. 79:1994;181-184.
13. Morishita R., Gibbons G.H., Ellison K.E., Nakajima M., Leyen H., Zhang L., Kaneda Y., Ogihara Y., Dzau V.J. Intimal hyperplasia after vascular injury is inhibited by antisence cdk 2 kinase oligonucleotides. J. Clin. Invest. 93:1994;1458-1464.
14. Yang Z.Y., Simari R.D., Perkins N.D., San H., Gordon D., Nabel G.J., Nabel E.G. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc. Natl. Acad. Sci. USA. 93:1996;7905-7910.
15. Fukui R., Shibata N., Kohbayashi E., Amakawa M., Furutama D., Hoshiga M., Negoro N., Nakakouji T., Ii M., Ishihara T., Ohsawa N. Inhibition of smooth muscle cell migration by the p21 cyclin-dependent kinase inhibitor (Cip1). Atherosclerosis. 132:1997;53-59.
16. Lowe S.W., Ruley H.E., Jacks T., Housman D.E. p53-Dependent apoptosis modulates the cytotoxity of anticancer agents. Cell. 74:1993;957-967.
17. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potencial mediator of p53 tumor suppression. Cell. 75:1993;817-825.
18. Han D.K.M., Haudenschild C.C., Hong M.K., Tinkle B.T., Leon M.B., Liau G. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am. J. Pathol. 147:1995;267-277.