Cytochrome P450 1A1 in rat peripheral blood lymphocytes: Inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 438, Issue 1, 1999, Pages 1-12

  Fung, Jacqueline ^a   Thomas, Paul E ^a   Iba, Michael M ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Ames test; CYP1A1 induction; Dexamethasone; Peripheral blood lymphocyte; Polyaromatic hydrocarbon; Pyridine

Indexed keywords

3 METHYLCHOLANTHRENE; BENZO[A]PYRENE; BETA NAPHTHOFLAVONE; BROMOBENZENE; CIGARETTE SMOKE; DEXAMETHASONE; ETHOXYRESORUFIN DEETHYLASE; PYRIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; INHALATIONAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; MUTAGEN TESTING; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ANIMALS; BENZO(A)PYRENE; BETA-NAPHTHOFLAVONE; BLOTTING, WESTERN; BROMOBENZENES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DEXAMETHASONE; ENZYME INDUCTION; LYMPHOCYTES; MALE; METHYLCHOLANTHRENE; MUTAGENICITY TESTS; MUTAGENS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM; SMOKING;

SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032923663     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(98)00149-1     Document Type: Article

References (58)

1. Gonzalez F.J. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40:1988;243-288.
2. Kimura S.F., Gonzalez F.J., Nebert D.W. Tissue-specific expression of the mouse dioxin-inducible P1-450 and P3-450: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Mol. Cell. Biol. 6:1986;1471-1477.
3. Kellerman G., Shaw C.R., Luyten-Kellerman M. Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. New Engl. J. Med. 289:1973;934-937.
4. Kouri R.E., McKinney C.E., Slomiany D.J., Snodgrass D.R., Wray N.P., McLemore T.L. Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. Cancer Res. 42:1982;5030-5037.
5. Ryan D.E., Levin W. Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacol. Ther. 45:1990;153-239.
6. Shimada T., Yun C.-H., Yamazaki H., Gautier J.-C., Beaume P.H., Guengerich F.P. Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. Molec. Pharmacol. 41:1982;856-864.
7. Nebert D.W. The [Ah] locus: genetic differences in toxicity, cancer, mutation and birth defects. CRC Crit. Rev. Toxicol. 20:1989;153-174.
8. Kouri R.E., Imblum R.L., Sosnowski R.G., Slomiany D.J., Snodgrass D.R., McKinney C.E. Parameters influencing quantitation of 3-methylcholanthrene-induced aryl hydrocarbon hydroxylase activity in cultured human lymphocytes. J. Environ. Pathol. Toxicol. 2:1979;1079-1098.
9. R.E. Kouri, A.S. Levine, B.K. Edwards, T.L. McLemore, E.S. Vessel, D.W. Nebert, Source of interindividual variations in aryl hydrocarbon hydroxylase in mitogen-activated human lymphocytes, in: G.S. Omenn, H.V. Gelboin (Eds.), Genetic Variability in Responses to Chemical Exposure, Cold Spring Harbor Laboratory (1984), Banbury Report 16, pp. 131-144.
10. B. Paigen, E. Ward, A. Reilley, H.L. Gurtoo, J. Minowada, K. Steenland, M.B. Havens, P. Sartori, Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes, Cancer Res. (1981), 2757-2761.
11. Rojas M., Camus A.-M., Alexandrov K., Hausgafret-Pursiainen K., Anttila S., Vainio H., Bartsch H. Stereoselective metabolism of (-)-benzo[a]pyrene-7,8-diol by human lung microsomes and peripheral blood lymphocytes. Carcinogenesis. 13:1992;929-933.
12. Karki N., Pokela R., Nuutinen L., Pelkonen O. Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls. Int. J. Cancer. 39:1987;565-570.
13. Gurtoo H.L., Vaught J.B., Marinello A.J., Paigen B., Gessner T., Bolanowska W. High-pressure liquid chromatographic analysis of benzo(a)pyrene metabolism by human lymphocytes from donors of different aryl hydrocarbon hydroxylase inducibility and antipyrine half-lives. Cancer Res. 40:1980;1305-1310.
14. Shimada T., Iwasaki M., Martin M.V., Guengerich F.P. Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Res. 49:1989;3218-3228.
15. Cosma G.N., Toniolo P., Currie D., Pasternak B.S., Garte S.J. Expression of CYP1A1 gene in peripheral lymphocytes as a marker of exposure to creosote in railroad workers. Cancer Epidemiol. Biomarkers Prev. 1:1992;137-142.
16. Vanden Heuvel J.P., Clark G.C., Thompson C., McCoy Z., Miller C.R., Lucier G.W., Bell D.A. CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis. 14:1993;2003-2006.
17. Hukkanen J., Hakkola J., Antilla S., Piipari R., Karjalainen A., Pelkonen O., Raunio H. Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. Mol. Carcinogenesis. 20:1997;224-230.
18. Fung J., Scholl H., Park Y., Thomas P.E., Iba M.M. CYP1A1 induction by mainstream (ms) and sidestream (ss) cigarette smoke (cs) in rat tissues: kinetics and dose-response relationships. Toxicol. Sci. 42S:1998;95.
19. Anderson L.M., Ward J.M., Park S.S., Rice J.M. Immunohistochemical localization of cytochromes P450 with polyclonal and monoclonal antibodies. Pathol. Immunopathol. Res. 8:1989;61-94.
20. Voigt J.M., Kawabata T.T., Burke J.P., Martin M. V, Guengerich F.P., Baron J.F. In situ localization and distribution of xenobiotic-activating enzymes and aryl hydrocarbon hydroxylase activity in lungs of untreated rats. Molec. Pharmacol. 37:1990;182-191.
21. Okamoto T., Mitsuhashi M., Fujita I., Sindhu R.K., Kikkawa Y. Induction of cytochrome P450 1A1 and 1A2 by hyperoxia. Biochem. Biophys. Res. Commun. 197:1993;878-885.
22. M.M. Iba, J. Alam, C. Touchard, P.E. Thomas, A. Ghosal, J. Fung, Coordinate upregulation of CYP1A1 and HO-1 expression and modulation of δ-aminolevulinic acid synthetase and tryptophan pyrrolase activities in pyridine-treated rats, submitted for publication.
23. Sidhu J.S., Omiecinski C.J. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics. 5:1995;24-36.
24. Iba M.M., Bennett S., Storch A., Thomas P.E. Synergistic induction of CYP1A1 and CYP1A2 by acetone in combination with pyridine. Cancer Lett. 74:1993;69-74.
25. Griffith R.B., Standafer S. Simultaneous mainstream-sidestream smoke exposure systems: II. The rat exposure system. Toxicology. 35:1985;13-24.
26. Wottawa A., Klein G., Altman H. A method for the isolation of human and animal lymphocytes with Ficoll-Urographin. Wiener Klin. Wochenssch. 86:1974;161-163.
27. Lowry O.H., Rosenbrough A.L., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
28. Iba M.M., Thomas P.E. Activation of 3,3′-dichlorobenzidine in rat liver microsomes to mutagens: involvement of cytochrome P-450d. Carcinogenesis. 9:1988;717-723.
29. Thomas P.E., Reik L.M., Ryan D.E., Levin W. Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes. J. Biol. Chem. 259:1984;3890-3899.
30. Iba M.M., Alam J. Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3′-dichlorobenzidine and some other inducers of P450. Redox Report. 1:1995;279-286.
31. ISF/BNF-G. Arch. Biochem. Biophys. 244:1985;261-272.
32. Chomczynski P., Sacchi A. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry. 162:1987;156-159.
33. Maron D., Ames B.N. Revised methods for the Salmonella test. Mutat. Res. 113:1983;173-215.
34. McLemore T.L., Adelberg S., Liu M.C., McMahon N.A., Yu S.J., Hubbard W.C., Czerwinski M., Wood T.G., Storeg R., Lubert R.A., Eggleston J.C., Boyd M.R., Hines R.N. Expression of CYP1A1 gene in patients with lung cancer: Evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. J. Natl. Cancer Inst. 82:1990;1333-1339.
35. Scholl H., Iba M.M. Pharmacokinetics of and CYP1A induction by pyridine and acetone in the rat: interactions and effect of route of exposure. Xenobiotica. 27:1997;265-277.
36. Kim S.G., Reddy S.L., States J.C., Novak R.F. Pyridine effects on expression and molecular regulation of the cytochrome P-450IA gene subfamily. Mol. Pharmacol. 40:1991;52-57.
37. Guzelian P.S., Elshougbary N.A. Induction of hepatic heme oxygenase activity by bromobenzene. Arch. Biochem. Biophys. 196:1979;178-185.
38. Jugert F.K., Agarwal R., Kuhn A., Bickers D.R., Merk H.F., Mukhtar H. Multiple cytochrome P450 isozymes in murine skin: Induction of P450 1A, 2B, 2E, and 3A by dexamethasone. Invest. Dermatol. 102:1994;970-975.
39. M.W. Linder, R.A. Prough, Regulation of hepatic drug detoxification enzymes by 3-methylcholanthrene and dexamethasone in fetal, neonatal, and adolescent rats. Proceedings of the VIIIth International Symposium on Microsomes and Drug Oxidations, Stockholm, June 25-29, 1990, Abstract #172, p. 79.
40. Cooper K.O., Reik L.M., Jayyosi Z., Bandiera S., Kelley M., Ryan D.E., Daniel R., McCluskey S.A., Levin W., Thomas P.E. Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch. Biochem. Biophys. 301:1993;345-354.
41. Nebert D.W. Role of genetics and drug metabolism in human cancer risk. Mutat. Res. 247:1991;267-281.
42. Hankinson O. The aryl hydrocarbon receptor complex. Ann. Rev. Pharmacol. Toxicol. 35:1995;307-340.
43. Okey A.B., Bondy G.P., Mason M.E., Kahl G.F., Eisen H.G., Guenthner T.M., Nebert D.W. Regulatory gene product of the Ah locus. Characterization of cytosolic inducer-receptor complex and evidence of its nuclear translocation. J. Biol. Chem. 254:1979;11636-11648.
44. Mathis J.M., Houser W.H., Bresnick E., Cidlowski J.A., Hines R.N., Prough R.A., Simpson E.R. Glucocorticoid regulation of rat cytochrome P450c (P450IA1) gene: receptor binding with intron I. Arch. Biochem. Biophys. 269:1989;93-105.
45. Raha A., Joyce T., Gusky S., Bresnick E. Glycine N-methyltransferase is a mediator of cytochrome P450 1A1 gene expression. Arch. Biochem. Biophys. 322:1995;395-404.
46. Pasco D., Boyum K.W., Merchant S.N., Charlberg S.C., Fagan J.B. Transcriptional and post-transcriptional regulation of the genes encoding cytochromes P-450c and P-450d in vivo and in primary hepatocyte cultures. J. Biol. Chem. 263:1988;8671-8676.
47. R.B. Crawford, M.P. Holsaples, N.E. Kaminski, Leukocyte activation induces aryl hydrocarbon receptor upregulation, DNA binding, and increased Cyp1a1 expression in the absence of exogenous ligand, 52 (1997) 921-927.
48. Jones C.L., Reiners J.J. Differentiation status of cultured murine keratinocytes modulates induction of genes responsive to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 347:1997;163-173.
49. Din X., Peng H.-M., Pernecky S.J., Davis C.J., Coon M.J. Induction of P-450 cytochromes 2E2, 1A1, and 1A2 by imidazole in neonatal rabbits. Drug Metab. Dispo. 20:1992;792-796.
50. Pirmohamed M., Allott R., Green V.J., Kitteringham N.R. Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy. Br. J. Clin. Pharmacol. 37:1994;577-581.
51. Yamasaki E., Ames B.N. Concentration of mutagens from urine by adsorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine. Proc. Natl. Acad. Sci. USA. 74:1977;3555-3559.
52. Schmitt M., Doffoel M., Diebold-Simoni P., Toussaint J.-L., Kempf J. Reduced benzo-a-pyrene activation potential in lymphocytes from chronic alcoholics. Alcohol. 7:1990;137-143.
53. Hu Z., Wells P.G. Modulation of benzo[a]pyrene bioactivation by glucuronidation in lymphocytes and hepatic microsomes from rats with hereditary deficiency in bilirubin UDPG-glucuronosyltransferase. Toxicol. Appl. Pharmacol. 127:1994;306-313.
54. Ross J., Nelson G., Erexson G., Kligerman A., Earley K., Gupta R.C., Nesnow S. DNA adducts in rat lung, liver and peripheral blood lymphocytes produced by i.p. administration of benzo[a]pyrene metabolites and derivatives. Carcinogenesis. 12:1991;1953-1955.
55. Ross J., Nelson G., Kligerman A., Erexson G., Bryant M., Early K., Gupta R., Nesnow S. Formation and persistence of novel benzo(a)pyrene adducts in rat lung, liver, and peripheral blood lymphocyte DNA. Cancer Res. 50:1990;5088-5094.
56. 32P -postlabeling analysis Carcinogenesis. 11:1990;205-211.
57. Song B.-J., Gelboin H.V., Park S.S. Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes. Science. 228:1985;490-492.
58. Law M.R. Genetic predisposition to cancer. Br. J. Cancer. 61:1990;195-206.