Measurement of lymphatic function with technetium-99m-labelled polyclonal immunoglobulin

European Journal of Nuclear Medicine

Volumn 26, Issue 5, 1999, Pages 504-510

  Svensson, W ^a,b   Glass, D M ^a   Bradley, D ^a   Peters, A M ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b EALING HOSPITAL   (United Kingdom)

Author keywords

Lymph flow; Lymph node function; Lymphoscintigraphy; Post mastectomy oedema

Indexed keywords

HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M;

ARTICLE; CLINICAL ARTICLE; DRUG CLEARANCE; HUMAN; LYMPH FLOW; LYMPH NODE; LYMPH VESSEL; LYMPHOSCINTIGRAPHY; SUBCUTANEOUS DRUG ADMINISTRATION;

FEMALE; FOREARM; HAND; HUMANS; IMMUNOGLOBULINS; LYMPH; LYMPHATIC SYSTEM; LYMPHEDEMA; POSTOPERATIVE COMPLICATIONS; RADIOPHARMACEUTICALS; TECHNETIUM; TECHNETIUM TC 99M AGGREGATED ALBUMIN;

EID: 0032923003     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590050418     Document Type: Article

References (24)

1. 1. Stanton AWB, Levick JR, Mortimer PS. Current puzzles presented by post mastectomy oedema (breast cancer related lymphoedema). Vasc Med 1996; 1: 213-225.
2. 2. Jepson RP, Simeone FA, Dobyns BM. Removal from skin of plasma protein labelled with radioactive iodine. Am J Physiol 1953; 175: 443-448.
3. 3. Nawaz K, Hamad M, Sadek S, Audeli M, Higazi E, Eklof B, Abdel-Dayem HM. Lymphoscintigraphy in peripheral lymphedema using technetium-labelled human serum albumin: normal and abnormal patterns. Lymphology 1985; 18: 181-186.
4. 4. Weissleder H, Weissleder R. Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients. Radiology 1988; 167: 729-735.
5. 5. Suga K, Uchisako H, Nakanishi T et al. Lymphoscintigraphic assessment of leg oedema following arterial reconstruction using a load produced by standing. Nucl Med Commun 1991; 12: 907-917.
6. 6. Sage HH, Sinha BK, Kizilay D, Toulon R. Radioactive colloidal gold measurements of lymph flow and functional patterns of lymphatics and lymph nodes in the extremities. J Nucl Med 1964; 5: 626-642.
7. 7. Zim Winkel K, Herman HJ. Scintigraphy of lymphnodes. Lymphology 1997; 10: 107-114.
8. 8. Hultbern KA, Larson LG, Ragnhu HIL. The lymph drainage from the breast to the axillary and parasternal lymph nodes studied with the aid of colloidal Au-198. Acta Radiol 1955; 43: 52.
9. 9. Aspergen K, Stryand SE, Person BRR. Quantitative lymphoscintigraphy for detection of metastases to the internal mammary lymph nodes: biokinetics of Tc99m sulphur colloid uptake and correlation with microscopy. Acta Radiol Oncol 1987; 17: 17.
10. 10. Stewart G, Gaunt JI, Croft DN, Browse NL. Isotope lymphography: a new method of investigating the role of the lymphatics in chronic limb oedema. Br J Surg 1985; 72: 906-909.
11. 99mTc-labelled dextran. J Nucl Med 1982; 23: 923-929.
12. 12. Freedman DO, de Almeida Filho PJ, Besh S, Maia e Silva MC, Braga C, Maciel A, Furtado AF. Abnormal lymphatic function in presymptomatic Bancroftian filariasis. J Infect Dis 1995; 171: 997-1001.
13. 13. Taylor GW, Kinmonth JB, Rollinson E, Rotblat J, Francis GE. Lymphatic circulation studied with radioactive plasma protein. Br Med J 1951; 1: 133-137.
14. 14. Hollander W, Riley P, Burrows BA. Lymphatic flow in human subjects as indicated by the disappearance of iodine labelled albumin from the subcutaneous tissues. J Clin Invest 1961; 40: 222-233.
15. 15. Battezatti M. Donini I. The role of radioisotopes in the study of the physiopathology of the lymphatic system. J Cardiovasc Surg 1964; 56: 691-693.
16. 16. Emmet AJS, Barron JN, Veall N. The use of I-131 albumin tissue clearance measurements and other physiological tests for the clinical assessment of patients with lymphoedema. Br J Plast Surg 1967; 20: 1-15.
17. 17. Harvey RF. The use of 131-I labelled human serum albumin in the assessment of improved lymph low following buried dermis flap operation in cases of post mastectomy lymphoedema of the arm. Br J Radiol 1961; 42: 260-265.
18. 18. Bates DO, Levick JR, Mortimer PS. Changes in macromolecular composition of interstitial fluid from swollen arms after breast cancer treatment, and its implications. Clin Sci 1993; 85: 737-746.
19. 19. Svensson WE, Mortimer PS, Tohno E, Cosgrove DO. Colour Doppler demonstrates venous flow abnormalities in breast cancer patients with chronic arm swelling. Eur J Cancer 1994; 30 A: 657-660.
20. 20. Svensson WE, Mortimer PS, Tohno E, Cosgrove DO. Increased arterial inflow demonstrated by Doppler ultrasound in arm swelling following breast cancer treatment. Eur J Cancer 1994; 30A: 661-664.
21. 21. Casley-Smith JR, Clodius L, Piller NB. Tissue changes in chronic experimental lymphoedema in dogs. Lymphology 1980; 13: 130-141.
22. 22. Roberts CC, Stanton AWB, Pullen J, Bull RH, Levick JR, Mortimer PS. Skin microvascular architecture and perfusion studied in human postmastectomy oedema by intravital video-capillaroscopy. Int J Microcirc 1994; 14: 327-334.
23. 23. Elkon KB, Ferjencik PP, Walport MJ, Peters AM, Lewis SM, Hughes GRV. Evaluation of heat damaged and IgG-coated red cells for testing reticulo-endothelial function. J Immunol Methods 1982; 55: 253-226.
24. 24. Wahl RL, Geatti O, Leibert M, Wilson B, Shreve P, Beers BA. Kinetics of interstitially administered monoclonal antibodies for purposes of lymphoscintigraphy. J Nucl Med 1987; 58: 1736-1744.