Macrophage-derived superoxide is not required for nitric oxide mediated tumour cell killing by RAW 264 cells

Anticancer Research

Volumn 19, Issue 1 A, 1999, Pages 553-556

  Fricker, Simon P ^a   Slade, Elizabeth ^b   Powell, Nigel A ^b  

^a GENZYME CORPORATION   (United States)

^b JOHNSON MATTHEY TECHNOLOGY CENTRE   (United Kingdom)

Author keywords

Macrophage; Nitric oxide; Superoxide; Tumour

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; MACROPHAGE; MASTOCYTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; MACROPHAGES; MAST-CELL SARCOMA; MICE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032922469     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Hibbs Jr JB, Vavrin, Z, and Taintor RR: L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 138: 550-565, 1987.
2. Hibbs Jr JB, Taintor RR, Vavrin Z and Rachlin EM: Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157: 87-94, 1988.
3. Stuehr DJ, and Nathan CF: A macrophage product responsible for cytostasis and respiratory inhibition in tumour target cells. J Exp Med 169: 1543-1555, 1989.
4. Lancaster Jr JR and Hibbs Jr JB: EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci USA: 87: 1223-1227, 1990.
5. Hibbs Jr. JB: Cytokine induced synthesis of nitric oxide from L-arginine: a cytotoxic mechanism that targets intracellular iron. In: Iron in central nervous system disorders. Key topics in brain research. (Reiderer P and Youdim MBH, eds), Vienna Springer Verlag, pp 155-171, 1993.
6. Cleeter MWJ, Cooper JM, Darley-Usmar VM, Moncada S, and Schapira AHV: Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. FEBS Lett 345: 50-54, 1994.
7. Ischiropoulos H, Zhu L and Beckman JS: Peroxynitrite formation from macrophage derived nitric oxide. Arch Biochem Biophys 298: 446-451, 1992.
8. Beckman JS, Beckman TW, Chen J, Marshall PA and Freeman BA: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624, 1990.
9. Hogg N, Darley-Usmar VM, Wilson MT and Moncada S: Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J 281: 419-424, 1992.
10. Darley-Usmar VM, Hogg N, O'Leary VJ, Wilson MT and Moncada S: The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Free Rad Res Comms 17: 9-20, 1992.
11. King PA, Anderson VE, Edwars J, Gustafson G and Suggs J: A stable solid that generates hydroxyl radical upon dissolution in aqueous solution: Reaction with proteins and nucleic acid. J Amer Chem Soc 114: 5430-5432, 1992.
12. Radi R, Beckman JS, Bush KM and Freeman BA: Peroxynitrite oxidation of sulfhydryls. J Biol Chem 266: 4244-4250, 1991.
13. Raschke WC, Baird S, Ralph P and Nakoinz I: Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 15: 261-267, 1978
14. Marietta MA, Yoon PS, Iyengar R, Leaf CD and Wishnok JS: Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry 27: 8706-8711, 1988.
15. Riley DP and Weiss RH: Manganese macrocyclic ligand complexes as mimics of superoxide dismutase. J Amer Chem Soc 116: 387-388, 1994.
16. 15N]nitrate in biological fluids. Anal Biochem 126: 131-138, 1982.
17. Borenfreund E and Puerner JA: Toxicity determined in vitro by morphological alterations and neutral red absorption.Toxicology Lett 24: 119-224, 1985.
18. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
19. Fricker SP and Buckley RG: Comparison of two colorimetric assays as cytotoxicity endpoints for an in vitro screen for antitumour agents. Anticancer Res 16: 3755-3760, 1996.
20. Pick E and Mizel D: Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J Immunol Methods 46: 211-226, 1981.
21. Pick E, Charon J and Mizel D: A rapid densitometric microassay for nitroblue tetrazolium reduction and application of the microassay to macrophages. J Reticuloendothel Soc 30: 581-593, 1981.
22. McCord JM and Fridovich I: Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244: 6049-6055, 1969.
23. Beauchamp C and Fridovich I: Superoxide dismutase. Improved assays and an assay applicable to acrylamide gels. Anal Biochem 44: 276-287, 1971.
24. Higuchi M, Higashi N, Taki H and Osawa T: Cytolytic mechanisms of activated macrophages. Tumour necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages. J Immunol 144: 1425-1431, 1990.
25. Davies NA, Wilson MT, Slade E, Fricker SP, Murrer BA, Powell NA and Henderson GR: Kinetics of nitric oxide scavenging by ruthenium(III) polyaminocarboxylates: novel therapeutic agents for septic shock. Chem Commun. 47-48, 1997.
26. Fricker SP, Slade E, Powell NA, Vaughan OJ, Henderson GR, Murrer BA, Megson IL, Bisland ST, Loveland M and Flitney FW: Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide-mediated diseases. Br J Pharmacol 122: 1441-1449, 1997.
27. Hausladen A and Fridovich I: Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. J Biol Chem 47: 29405-29408, 1994.
28. Castro L, Rodriguez M and Radi R: Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J Biol Chem 47: 29409-29415, 1994.
29. Cross AR and Jones OTG: Enzyme mechanisms of superoxide production. Biochim Biophys Acta 1057: 281-298, 1991.
30. Roberts PA, Cross AR, Jones OTG and Segal AW: Development of cytochrome b and an active oxidase system in association with maturation of a human promyelocytic (HL60) cell line. J Cell Biol 95: 720-726, 1982.
31. Andrew PW, Robertson AK, Lowrie DB, Cross AR and Jones OTG: Induction of synthesis of components of the hydrogen peroxide -generating oxidase during activation of the human monocytic cell line U937 by interferon - γ. Biochem J 248: 281-283, 1987.
32. Black SC, Schasteen CS, Weiss RH, Riley DP, Driscoll EM and Lucchesi BR: Inhibition of in vivo myocardial ischaemia and reperfusion injury by a synthetic manganese-based superoxide dismutase mimic. J Pharmacol Exp Ther 270: 1208-1215, 1994.
33. Hafeman DG, Seul M, Cliffe CM and McConnell HM: Superoxide enhances photobleaching during cellular immune attack against fluorescent lipid monolayer membranes. Biochim Biophys Acta 772: 20-28, 1984.
34. Assreuy J, Cunha FQ, Epperlein M, O'Donnell CA, Liew FY and Moncada S: Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major. Eur J Immunol 24: 672-676, 1994.
35. Taffet SM., Singhel KJ, Overholtzer JF, and Shurtleff SA: Regulation of Tumor Necrosis Factor expression in a macrophage cell line by lipopolysaccharide and cyclic AMP. Cell Immunol 120: 291-300, 1989.
36. Eigler A, Moeller J, and Endres: Exogenous and endogenous nitric oxide attenuates tumour necrosis factor synthesis in the murine macrophage cell line RAW264.7. J Immunol 154: 4048-4054, 1995.
37. Van L, Wang S, Rafferty SP, Wesley RA, and Danner RL: Endogenously produced nitric oxide increases tumour necrosis factor-α production in transfected human U937 cells. Blood 90: 1160-1167, 1997.
38. Ryoyama K: Effector molecules from antitumour macrophages induced with OK-432 and cyclophosphamide. Cancer Immunol Immunother 35: 7-13, 1992.