Depletion of brain norepinephrine: Differential influence on anxiolyic treatment effects

Psychopharmacology

Volumn 143, Issue 2, 1999, Pages 197-208

  Fontana, David J ^a   McMiller Jr , Love V ^a   Commissaris, Randall L ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alprazolam; Antidepressants; Anxiety; Anxiolytics; Barbiturates; Benzodiazepines; Conflict behavior; Desipramine; DSP4; Generalized anxiety disorder; Norepinephrine; Panic disorder; Phenelzine; Phenobarbital

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; DESIPRAMINE; NORADRENALIN; PHENELZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; ARTICLE; CATECHOLAMINE DEPLETION; CONFLICT; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; MEMBRANE DEPOLARIZATION; NEUROTRANSMISSION; NONHUMAN; NORADRENALIN BRAIN LEVEL; PANIC; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; TRANQUILIZING ACTIVITY;

ALPRAZOLAM; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BENZYLAMINES; BIOGENIC MONOAMINES; BRAIN CHEMISTRY; CONFLICT (PSYCHOLOGY); DESIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPNOTICS AND SEDATIVES; MONOAMINE OXIDASE INHIBITORS; NOREPINEPHRINE; PHENELZINE; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHOMIMETICS;

EID: 0032922250     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050936     Document Type: Article

References (67)

1. Amaral EG, Sinnamon HM (1977) The locus coeruleus: neurobiology of a central noradrenergic nucleus. Prog Neurobiol 9:147-196
2. Baldessarini RJ (1996) Drugs and the treatment of psychiatric disorders: psychoses and anxiety. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG (eds) Goodman and Gilman's the pharmacological basis of therapeutics. McGraw-Hill, New York, pp 399-430
3. Blier P, deMontigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220-226
4. Bowery NG, Price GW, Hudson AL, Wilkin GP, Turnbull MJ (1984) GABA receptor multiplicity. Neuropharmacology 23:219-231
5. Bremner JD, Krystal JH, Southwick SM, Charney DS (1996) Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. Synapse 23:28-38
6. Britton R, Ksir C, Koob G (1981) Effects of dorsal noradrenergic bundle lesions on measures of conflict, learning and locomotion. Neurosci Abstr 113.10
7. Charney DS, Heninger GR (1985) Noradrenergic function and the mechanism of action of anti-anxiety treatments: II. The effects of long-term imipramine treatment. Arch Gen Psychiatry 42:473-481
8. Charney DS, Krystal JH, Southwick SM, Delgado PL (1994) The role of noradrenergic function in human anxiety and depression. In : den Boer JA, Sitsen JMA (eds) Handbook of depression and anxiety. Marcel Dekker, New York, pp 473-496
9. Chouinard G, Annable L, Fontaine R (1982) Alprazolam in the treatment of generalized anxiety and panic disorders: a double-blind placebo controlled study. Psychopharmacology 77:229-233
10. Commissaris RL (1993) Conflict behaviors as animal models for the study of anxiety. In: vanHarren F (ed) Methods in behavioral pharmacology. Elsevier, New York, pp 443-474
11. Commissaris RL, Ellis DM, Hill TJ, Schefke DM, Becker CA, Fontana DJ (1990) Chronic antidepressant and clonidine treatment effects of conflict behavior in the rat. Pharmacol Biochem Behav 37:167-176
12. Commissaris RL, Fontana DJ (1991) Pharmacological evaluation of potential animal models for the study of antipanic and panicogenic treatments. In: Boulton A, Baker G, Martin-Iverson M (eds) Neuromethods volume 19. Animal Models in psychiatry II. Humana Press, Clifton, N.J., pp 199-232
13. Commissaris RL, Humrich J, Johns J, Geere DG, Fontana DJ (1995) The effects of selective and non-selective monoamine oxidase (MAO) inhibitors on conflict behavior in the rat. Behav Pharmacol 6:95-202
14. Cook L, Davidson AB (1973) Effects of behaviorally active drugs in a conflict-punishment procedure in rats. In: Garattini S, Randall LO (eds) The benzodiazepines. Raven Press, New York
15. Cook L, Sepinwall J (1975) Behavioral analysis of the effects and mechanisms of actions of benzodiazepines. In: Costa E, Greengard P (eds) Mechanism of action of benzodiazepines. Raven Press, New York, pp 1-28
16. Dooley DJ, Bittiger H, Hauser SF, Waldmeier PC (1983) Alterations of central alpha-2-and beta-adrenergic receptors in the rat after DSP-4, a selective noradrenergic neurotoxin. Neuroscience 9:889-898
17. Ellison GD (1977) Animal models of psychopathology. The low-norepinephrine and low-serotonin rat. Am Psychol 32:1036-1045
18. Feldman RS, Meyer JS, Quenzer LF (1997) Principles of neuropsychopharmacology. Sinauer Associates, Sunderland, Mass., pp 819-860
19. File SE, Hyde IR (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62:19-24
20. Fontana DJ, Commissaris RL (1988) Effects of acute and chronic imipramine on conflict behavior in the rat: a potential animal model for the study of panic disorder? Psychopharmacology 95:147-150
21. Fontana DJ, Commissaris RL (1992) Anxiolytic-like effects of alpha-2-adrenoceptor agonists on conflict behavior in the rat: Pre-versus post-synaptic mechanisms. Behav Pharmacol 43:697-704
22. Fontana DJ, Carbary TJ, Commissaris RL (1989a) Effects of acute and chronic anti-panic drug administration on conflict behavior in the rat. Psychopharmacology 98:157-162
23. Fontana DJ, McCloskey TC, Jolly SK, Commissaris RL (1989b) The effects of beta-antagonists and anxiolytics on conflict behavior in the rat. Pharmacol Biochem Behav 32:807-813
24. Fontana DJ, Schefke DM, Commissaris RL (1990) Acute versus chronic clonidine treatment effects on conflict behavior in the rat. Behav Pharmacol 1:201-208
25. Garakani H, Zitrin CH, Klein DF (1984) Treatment of panic disorder with imipramine alone. Am J Psychiatry 144:446-448
26. Geller I, Seifter J (1960) The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally-induced conflict in the rat. Psychopharmacology 1:482-492
27. 3H] DOPA in various regions of the brain. J Neurochem 13:655-669
28. Grant SJ, Huang YH, Redmond DE (1980) Benzodiazepines attenuate single unit activity in the locus coeruleus. Life Sci 27:2231-2236
29. Gray JA (1976) The behavioral inhibition system: a possible substrate for anxiety. In: Feldman MP, Broadhurst AM (eds) Theoretical and experimental bases of behavioral modification. Wiley, Chichester, pp 3-41
30. Haefely W, Pole P, Pieri L, Laurent JP (1983) Neuropharmacology of benzodiazepines: synaptic mechanisms and neural basis of action. In: Costa E (ed) The benzodiazepines: from molecular biology to clinical practice· Raven Press, New York, pp 21-61
31. Hallman I, Jonsson GH (1984) Pharmacological modifications of the neurotoxic action of the noradrenaline neurotoxin DSP4 on central noradrenaline neurons. Eur J Pharmacol 103:269-278
32. Ishikawa K, McGaugh JL (1982) Simultaneous determination of monoamine transmitters, precursors and metabolites in a single mouse brain. J Chromator 229:35-46
33. Iverson SD (1980) Animal models in anxiety and benzodiazepine action. Arzneimittel Forschung 30:862-868
34. Jaim-Etcheverry G, Zieher LM (1980) DSP4. A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res 118:513-523
35. Jonsson G, Hallman H, Ponzio F, Ross R (1981) DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzamine, a useful denervation tool for central and peripheral noradrenaline neurons. Eur J Pharmacol 72:173-188
36. Judd FK, Norman TR, Burrows GD (1986) Pharmacological treatment of panic disorder. Int Clin Psychopharmacol 1:3-16
37. Klein DF (1967) The importance of psychiatric diagnosis in prediction of clinical drug effects. Arch Gen Psychiatry 16:118-126
38. Klein DF, Fini M (1962) Psychiatric reaction patterns to imipramine. Am J Psychiatry 119:432-438
39. Koob GF, Strecker RE, Bloom FE (1980) Failure to alter anxiety or the anxiolytic properties of chlordiazepoxide and ethanol by destruction of the dorsal noradrenergic system. Neurosci Abstr:40.6
40. Laurent JP, Margold M, Humbel V, Haefley W (1983) Reduction by two benzodiazepines and pentobarbitone of the multi unit; activity in substantia nigra, hippocampus, nucleus locus coruleus and nucleus raphe donsalis of encephale isole rats. Neuropharmacology 22:501-512
41. Libet B, Gleason CA (1994) The human locus coeruleus and anxiogenesis. Brain Res 634:178-180
42. Lipper S, Murphy DL, Slater S, Buchsbaum MS (1979) Comparitive behavioral effects of clorgyline and pargyline in man : II preliminary evaluation. Psychopharmacology 62:123-128
43. Lydiard RB, Ballenger, JC (1985) Antidepressants in panic disorder and agoraphobia. Psychiat Med 3:112-118
44. Mason ST, Fibiger HC (1977) Altered exploratory behavior after 6-DHDA lesion to the dorsal noradrenergic bundle. Nature 259:704-705
45. Mavissakialian M, Michelson L, Dealy RS (1983) Pharmacological treatment of agoraphobia : imipramine versus imipramine with programmed practice. Br J Psychiatry 143:348-355
46. McCloskey TC, Paul BK, Commissaris RL (1987) Buspirone effects in an animal conflict procedure: comparison with diazepam and phenobarbital. Pharmacol Biochem Behav 27:171-175
47. Morris MD, Tremmel F, Gebhart GF (1979) Forebrain noradernaline depletion blocks the release by chlordiazepoxide of behavioral extinction in the rat. Neurosci Lett 12:343-348
48. A receptor-chloride channel complex. Annu Rev NY Acad Sci 625:145-154
49. Ravard S, Herve D, Thiebot MH, Soubrie P, Tassin JP (1990) Anticonflict-like effect of a prefrontal dopaminergic lesion in rats: permissive role of noradrenergic neurons. Behav Pharmacol 1:233-259
50. Redmond DE, Huang YH, Synder DR, Maas, JW (1976) Behavioral effects of stimulation of the nucleus locus coeruleus in the stump-tailed monkey Macaca artoides. Brain Res 94:502-510
51. Redmond DE (1979) New and old evidence for the involvement of a brain norepinephrine system in anxiety. In: Fann WE, (eds) The phenomenology and treatment of anxiety. Spectrum, New York, pp 153-303
52. Richards JC, Mohler H (1984) Benzodiazepine receptors. Neuropharmacology 23:233-242
53. 3 antagonists and benzodiazepines: their comparative behavioural pharmacology. Wiley, New York, pp 1-30
54. Ross SB (1976). Long term effects of N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurons in the rat brain and heart. Brit J Pharmacol 58:521-527
55. Schefke DM, Fontana DJ, Commissaris RL (1989) Anticonflict efficacy of buspirone following acute versus chronic treatment. Psychopharmacology 99:427-429
56. Sepinwall J, Cook L (1978) Behavioral pharmacology of anti-anxiety drugs. In: Iversen SD (ed) Psychopharmacology. Academic Press, New York
57. Sheehan DV, Coleman J, Greenblatt D, Jones K, Levine P, Orsalk P, Peterson M, Watkins D (1984) Some biochemical correlates of panic attacks with agoraphobia and their responses to new treatments. J Clin Psychopharmacol 4:66-75
58. Sheehan DV (1986) The tricyclic antidepressants in the treatment of panic and anxiety disorders. Psychosomatics 27:10-16
59. A receptor subtypes. Pharmacol Rev 47:181-234
60. Steele RGD, Torrie JH (1985) Priniciples and procedures of statistics. McGraw-Hill, New York
61. Stout JC, Cierpial MA, Boericke KM, Weiss JM (1992) Role of locus coeruleus-noradrenergic (LC-NE) system in anxious behavior in rats: decreased LC activity produces anxiogenic, while increased LC activity produces anxiolytic effects. Neurosci Abst 18:4
62. Sugrue MF (1983) Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning. Pharmacol Ther 21:1-33
63. Thiebot MH, Soubrie P, Doare L, Simon P (1984) Evidence against the involvement of a noradrenergic mechanism in the release by diazepam of novelty-induced hypophagja in rats Eur J Pharmacol 100:201-205
64. Verbanac JS, Commissaris RL, Altman HJ, Pitts DK (1994) Electrophysiological characteristics of locus coeruleus neurons in genetically-inbred anxious and non-anxious rat strains. Neurosci Lett 179:137-140
65. Verbanac JS, Altman HJ, Harrington GM, Commissaris RL (1993) Conflict behavior in the Maudsley Reactive and NonReactive rat strains: effects of noradrenergjc neuronal destruction. Pharmacol Biochem Behav 45:429-438
66. Vogel JR, Beer D, Clody DE (1971) A simple and reliable conflict procedure for testing anti-anxiety agents. Psychopharmacologia 21:1-7
67. Weiss JM, Stout JC, Aaron MF, Quan N, Owens MJ, Butler PD, Nemeroff CB (1994) Depression and anxiety: role of locus coeruleus and corticotropin-releasing factor. Brain Res Bull 35:561-572