Vesnarinone and glucocorticoids cooperatively induce G1 arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice

British Journal of Cancer

Volumn 80, Issue 1-2, 1999, Pages 96-103

  Honma, Y ^a   Yamamoto Yamaguchi, Y ^a   Kanatani, Y ^a  

^a SAITAMA CANCER CENTER   (Japan)

Author keywords

Differentiation; Glucocorticoid; Lung carcinoma; Vesnarinone; Xenograft

Indexed keywords

ALKALINE PHOSPHATASE; CARDIOTONIC AGENT; DEXAMETHASONE; GLUCOCORTICOID; PIPERANOMETOZINE;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; DRUG POTENTIATION; EXPERIMENTAL NEOPLASM; FEMALE; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

EID: 0032921748     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690327     Document Type: Article

References (34)

1. Alberts AS, Thorburn AM, Shenolikar S, Mumby MC and Feramisco JR (1993) Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci USA 90: 388-392
2. Beattie CW, Hansen NW and Thomas PA (1985) Steroid receptors in human lung cancer. Cancer Res 45: 4206-4214.
3. Chakrabarty S, Fan D and Varani J (1990) Modulation of differentiation and proliferation in human colon carcinoma cells by transforming growth factor β1 and β2. Int J Cancer 46: 493-499.
4. Chaudhuri PK, Thomas PA, Walker MJ, Briele HA, Gupta TKD and Beattie CW (1982) Steroid receptors in human lung cancer cytosols. Cancer Lett 16: 327-332
5. Christoffersen J, Smeland EB, Stokke T, Tasken K, Anderson KB and Blomhoff HK (1994) Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells. Cancer Res 54: 2245-2250
6. DeLemos RA, Shermeta DW, Knelson JH, Kotas R and Avery ME (1970) Acceleration of appearance of pulmonary surfactant in the fetal lamb by administration of corticosleroids. Am Rev Respir Dis 102: 459-461
7. Donnadieu N, Paesmans M and Sculier JP (1991) Chemotherapy of non-small lung cancer according to disease extent: a meta-analysis of the literature. Lung Cancer 7: 243-252
8. Don QP, An B and Will PL (1995) Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G, arrest and apoptosis. Proc Natl Acad Sci USA 92: 9019-9023
9. Edelson JD, Shannon JM and Mason RJ (1988) Alkaline phosphatase: a marker of alveolar type II cell differentiation. Am Rev Respir Dis 138: 1268-1275
10. Goto I, Hozumi M and Honma Y (1994) Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. Anticancer Res 14: 357-362
11. Goto I, Yamamoto-Yamaguchi Y and Honma Y (1996) Enhancement of sensitivity of human lung adenocarcinoma cells to growth-inhibitory activity of interferon-α by differentiation-inducing agents. Br J Cancer 74: 546-554
12. Hartwell LH and Kastan MB (1994) Cell cycle control and cancer. Science 266: 1821-1828
13. Hofmann J, Kaiser U, Maasberg M and Havemann K (1995) Glucocorticoid receptors and growth inhibitory effects of dexamethasone in human lung cancer cell lines. Eur J Cancer 31 A: 2053-2058
14. Jones KL, Anderson NS and Addison J (1978) Glucocorticoid-induced growth inhibition of cells from a human lung alveolar cell carcinoma. Cancer Res 38: 1688-1693
15. Kanatani Y, Kasukabe T, Hozumi M, Motoyoshi K, Nagata N and Honma Y (1993) Genistein exhibits preferential cytotoxicity to a leukemogenic variant but induces differentiation of a non-leukemogenic variant of the mouse monocytic leukemia Mm cell line. Leuk Res 17: 847-853
16. Kanatani Y, Kasukabe T, Okabe-Kado J, Hayashi S, Yamamoto-Yamaguchi Y, Motoyoshi K, Nagata N and Honma Y (1996) Transforming growth factor β and dexamethasone cooperatively enhance c-jun gene expression and inhibit the growth of human monocytoid leukemia cells. Cell Growth Diff 7: 187-196
17. Karp JE and Broder S (1995) Molecular foundations of cancer: new targets for intervention. Nature Med 1: 309-320
18. Kikkawa Y, Kaibara M, Motoyama EK and Cook CD (1971) Morphologic development of fetal rabbit lung and its acceleration with cortisol. Am J Pathol 64: 423-442
19. Laemmli UK (1970) Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
20. Liggins GC (1969) Premature delivery of fetal lambs infused with glucocorticoids. Endocrinology 45: 515-523
21. Liggins GC and Howie RNA (1972) Controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 50: 515-525
22. Ludlow JW, Glendening CL, Livingston DM and DeCaprio JA (1993) Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol 13: 367-372
23. Marchetti A, Doglion C, Barbareschi M, Buttitta F, Pellegrini S, Bertacca G, Chella A, Merlo G, Angeletti CA, Palma PD and Bevilacqua G (1996) p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene 12: 1319-1324
24. Mattern J, Klinga K, Rummebaum B and Volm M (1985) Influence of hormone therapy on human lung tumors transplanted into nude mice. Oncology 42: 388-390
25. McCormick C, Freshney RI and Speirs V (1995) Activity of interferonα, interleukin 6 and insulin in the regulation of differentiation in A549 alveolar carcinoma cells. Br J Cancer 71: 232-239
26. McLean JS, Frame MC, Freshney RI, Vaughan PFT, Mackie AE and Singer I (1986) Phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents. Anticancer Res 6: 1101-1106
27. Miyamoto G and Sasabe H (1984) Pharmacokinetics of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), in the rat, rabbit, beagle dog and rhesus monkey. Arzneimittel-Forschung Drug Res 34: 394-402
28. OPC-8212 Multicenter Research Group (1990) A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure. Cardiovasc Drug Ther 4: 419-426
29. Sato M, Harada K, Bando T, Shirakami T, Nakashiro K, Yoshida H, Nakai S, Kawai K and Adachi M (1995) Characteristics of antitumor activity of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone (Vesnarinone) against a human adenoid squamous carcinoma-forming cell line grown in athymic nude mice. Cancer Lett 91: 1-9
30. Sato S, Tomoyasu S, Okabe-Kado J, Hozumi M, Tsuruoka N, Nakai S, Adachi M and Honma Y (1996) Induction of differentiation and enhancement of vineristine sensitivity of human erythroleukemia HEL cells by vesnarinone, a positive inotropic agent. Exp Hematol 24: 37-42
31. Schroy P, Rifkin J, Coffey RJ, Winawer S and Friedman E (1990) Role of transforming growth factor β in induction of colon carcinoma differentiation by hexamethylene bisacetamide. Cancer Res 50: 261-265
32. Taira N, Endoh M, Iijima T, Satoh K, Yanagisawa T, Yamashita S, Maruyama M, Kawada M, Morita T and Wada Y (1984) Mode and mechanism of action of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2-(1H)-quinolinone (OPC-8212), a novel positive inotropic drug, on the dog heart. Arzneimittel-Forschung Drug Res 34: 35-43
33. Twardzik DR, Ranchalis JE, McPherson JM, Ogawa Y, Gentry L, Purchio A, Plata E and Todaro GJ (1989) Inhibition and promotion of differentiated-like phenotype of a human lung carcinoma in athymic mice by natural and recombinant forms of transforming growth factor-β. J Natl Cancer Inst 81: 1182-1185
34. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330