Bronchoscopic lavage with perfluorocarbon decreases postprocedure hypoxemia in an ovine model of smoke inhalation

Journal of Trauma - Injury, Infection and Critical Care

Volumn 46, Issue 1, 1999, Pages 129-135

  Cindrick, Lori L ^a   Gore, Dennis C ^a   Herndon, David N ^a   Traber, Lillian D ^a   Traber, Daniel L ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Acute lung injury; Adult respiratory distress syndrome; Bronchoscopic lavage; Perfluorocarbons; Sheep; Smoke inhalation

Indexed keywords

CARBON DIOXIDE; FLUOROCARBON; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BRONCHOSCOPY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SAFETY; HYPOXEMIA; LUNG BURN; LUNG GAS EXCHANGE; LUNG LAVAGE; LUNG PRESSURE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; SHEEP;

EID: 0032921428     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199901000-00022     Document Type: Conference Paper

References (23)

1. Herndon DN, Gore D, Cole M, et al. Determinants of mortality in pediatric patients with greater than 70% full-thickness total body surface area thermal injury treated by early total excision and grafting. J Trauma. 1987;27:208-212.
2. Cox CS, Zwischenberger JB, Traber DL, Traber LD, Haque AK, Herndon DN. Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model. Surg Gynecol Obstet. 1993;176:339-349.
3. Brown M. Desai M, Traber LD, Herndon DN, Traber DL. Dimethylsulfoxide with heparin in the treatment of smoke inhalation injury. J Burn Care Rehabil. 1988;9:22-25.
4. Jones JW, Rogers E. Artificial blood substitutes. CRNA. 1992;3:104-108.
5. Riess JG. Blood substitutes: where do we stand with the fluorocarbon approach? Curr Surg. 1988;45:365-370.
6. Tooley R, Hirschl RB, Parent A, Bartlett RH. Total liquid ventilation with perfluorocarbons increases pulmonary end-expiratory volume and compliance in the setting of lung atelectasis. Crit Care Med. 1996;24:268-273.
7. Hirschl RB, Pranikoff T, Wise C, et al. Initial experience with partial liquid ventilation in adult patients with the acute respiratory distress syndrome. JAMA. 1996;275:383-389.
8. Kimura R, Traber LD, Herndon DN, Linares HA, Lübbesmeyer HJ, Traber DL. Increasing duration of smoke exposure induces more severe lung injury in sheep. J Appl Physiol. 1988;64:1107-1113.
9. Walker HL, McLeod CGJ, McManus WF. Experimental inhalation injury in the goat. J Trauma. 1981;21:962-964.
10. Pearce ML, Yamashita J, Beazell J. Measurement of pulmonary edema. Circ Res. 1965;16:482-488.
11. Ward PA, Till GO, Hatherill JR, Annesley TM, Kunkel RG. Systemic complement activation, lung injury, and products of lipid peroxidation. J Clin Invest. 1985;76:517-527.
12. Weers JG. A physicochemical evaluation of perfluorochemicals for oxygen transport applications. Journal of Fluorine Chemistry. 1993;64:73-93.
13. Faithfull NS. Fluorocarbons: current status and future applications. Anaesthesia. 1987;42:234-242.
14. Shaffer TH, Wolfson MR, Clark LC Jr. Liquid ventilation. Pediatr Pulmonol. 1992;14:102-109.
15. Clark LC Jr, Gollan F. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science. 1966;152:1755-1756. Cited by: Lowe KC. Perfluorocarbons as oxygen-transport fluids. Comp Biochem Physiol. 1987;87:825-838.
16. Clark LC Jr, Gollan F. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science. 1966;152:1755-1756. Cited by: Lowe KC. Perfluorocarbons as oxygen-transport fluids. Comp Biochem Physiol. 1987;87:825-838.
17. Greenspan JS, Wolfson MR, Rubenstein SD, Shaffer TH. Liquid ventilation of human preterm neonates. J Pediatr. 1990;117:106-111.
18. Leach CL, Fuhrman BP, Morin FC, Rath MG. Perfluorocarbon-associated gas exchange (partial liquid ventilation) in respiratory distress syndrome: a prospective, randomized, controlled study. Crit Care Med. 1993; 21:1270-1278.
19. Shaffer TH, Ferguson JD, Koen PA, Moskowitz GD, Delivoria-Papadopoulos M. Pulmonary lavage in preterm lambs. Pediatr Res. 1978;12:695-698.
20. Calderwood HW, Modell JH, Ruiz BC, Brogdon JE, Hood CI. Pulmonary lavage with liquid fluorocarbon in a model of pulmonary edema. Anesthesiology. 1973;38:141-144.
21. Tutuncu AS, Faithfull NS, Lachmann B. Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome: dose-dependent improvement of gas exchange. Crit Care Med. 1993;21:962-969.
22. Lowe CA, Shaffer TH. Pulmonary vascular resistance in the fluorocarbon-filled lung. J Appl Physiol. 1986;60:154-159.
23. Tutuncu AS, Houmes RJ, Bos JA, Wollmer P, Lachmann B. Evaluation of lung function after intratracheal perfluorocarbon administration in healthy animals. Crit Care Med. 1996;24:274-279.