Analysis of interleukin 12 protein production and mRNA expression in mice exposed topically to chemical allergens

Toxicology

Volumn 132, Issue 1, 1999, Pages 57-66

  Warbrick, E V ^a   Dearman, R J ^a   Basketter, D A ^b   Kimber, I ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Contact sensitisation; Interleukin 12; Respiratory sensitisation; RT PCR

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; INTERLEUKIN 12; MESSENGER RNA; PROTEIN P40; TRIMELLITIC ANHYDRIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TOPICAL DRUG ADMINISTRATION;

ACETONE; ADMINISTRATION, TOPICAL; ALLERGENS; ANIMALS; CELLS, CULTURED; DINITROCHLOROBENZENE; DNA PRIMERS; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INTERLEUKIN-12; LYMPH NODES; MICE; MICE, INBRED BALB C; NADPH OXIDASE; PHTHALIC ANHYDRIDES; PLANT OILS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032920507     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(98)00137-1     Document Type: Article

References (41)

1. Aragane Y., Riemann H., Bhardwaj R.S., Schwarz A., Sawada Y., Yamada H., Luger T.A. et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol. 153:1994;5366-5372.
2. Bette M., Jin S.C., Germann T., Schafer M.K., Weihe E., Rude E., Fleischer B. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 10:1994;2435-2440.
3. Cher D.J., Mosmann T.R. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. J. Immunol. 138:1987;3688-3694.
4. D'Andrea A., Rengaraju M., Valiante N.M., Chehimi J., Kubin M., Aste M., Chan S.H. et al. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1992;1387-1398.
5. Dearman R.J., Ramdin L.S.P., Basketter D.A., Kimber I. Inducible interleukin-4-secreting cells provoked in mice during chemical sensitization. Immunology. 81:1994;551-557.
6. Dearman R.J., Basketter D.A., Kimber I. Differential cytokine production following chronic exposure of mice to chemical respiratory and contact allergens. Immunology. 86:1995;545-550.
7. Dearman R.J., Basketter D.A., Kimber I. Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice. Toxicol. Appl. Pharmacol. 138:1996a;308-316.
8. + T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens. Immunology. 89:1996b;502-510.
9. Dearman R.J., Smith S., Basketter D.A., Kimber I. Classification of chemical allergens according to cytokine secretion profiles of murine lymph node cells. J. Appl. Toxicol. 17:1997;53-62.
10. Gillessen S., Carvajal D., Ling P., Podlaski F.J., Stremlo D.L., Familletti P.C., Gubler U. et al. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 agonist. Eur. J. Immunol. 25:1995;200-206.
11. Gollob J.A., Kawasaki H., Ritz J. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol. 27:1997;647-652.
12. Heufler C., Koch F., Stanzl U., Topar G., Wysocka M., Trinchieri G. et al. Interleukin-12 is produced by dendritic cells and mediates T helper l development as well as interferon-γ production by T helper l cells. Eur. J. Immunol. 26:1996;659-668.
13. Hino A., Nariuchi H. Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells. Eur. J. Immunol. 26:1996;623-628.
14. + T cell. Immunol. Today. 15:1994;107-110.
15. Kimber I., Dearman R.J. Predictive assessment of respiratory sensitising potential of chemicals in mice. Kimber I., Dearman R.J. Toxicology of Chemical Respiratory Hypersensitivity. 1997;121-134 Taylor and Francis, London.
16. Kobayashi M., Fitz L., Ryan M., Hewick R.M., Clark S.C., Chan S., Loudon R. et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:1989;827-846.
17. Kohno K., Kataoka J., Ohtsuki T., Suemoto Y., Okamoto I., Ushi M., Ikeda M. et al. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158:1997;1541-1550.
18. Kubin M., Chow J.M., Trinchieri G. Differential regulation of interleukin-12 (IL-12), tumour necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood. 83:1993;1847-1855.
19. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-dependent. Int. Immunol. 5:1993;1119-1128.
20. Magram J., Connaughton S.E., Warrier R.R., Carvajal D.M., Wu C.-Y., Ferrante J. et al. IL-12 deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity. 4:1996;471-481.
21. Manetti R., Parronchi P., Giudizi M.G., Piccinni M.-P., Maggi E., Trinchieri G., Romagnani S. Natural killer cell stimulatory factor (interleukin 12 [IL12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1993;1199-1204.
22. Mohler K.M., Butler L.D. Quantitation of cytokine mRNA levels utilizing the reverse transcriptase-polymerase chain reaction following primary specific sensitization in vivo. 1. Verification of linearity, reproducibility and specificity. Mol. Immunol. 28:1991;437-447.
23. Morris S.C., Madden K.B., Adamovicz J.L., Gause W.C., Hubbard B.R., Gately M.K., Finkelman F.D. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1994;1047-1056.
24. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone. 1. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:1986;2348-2357.
25. Mosmann T.R., Coffman R.L. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:1989a;145-173.
26. Mosmann T.R., Coffman R.L. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv. Immunol. 46:1989b;111-147.
27. Muller G., Saloga J., Germann T., Bellinghausen I., Mohamadzadeh M., Knop J., Enk A.H. Identification and induction of human keratinocyte-derived IL-12. J. Clin. Invest. 94:1994;1799-1805.
28. Muller G., Saloga J., Germann T., Schuler G., Knop J., Enk A.H. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo. J. Immunol. 155:1995;4661-4668.
29. Nakamura T., Lee R.K., Nam S.Y., Podack E.R., Bottomly K., Flavell R.A. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158:1997;2648-2653.
30. Okamura H., Tsutsui H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T. et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature. 378:1995;88-91.
31. Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K. et al. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA. 93:1996;14002-14007.
32. Riemann H., Schwarz A., Grabbe S., Aragane Y., Luger T.A., Wysocka M., Kubin M. et al. Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance. J. Immunol. 156:1996;1799-1803.
33. Rogge L., Barberis-Maino L., Biffi M., Passini N., Presky D.H., Gubler U, Sinigaglia F. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:1997;825-831.
34. + T cells secreting Th1 or Th2 cytokines. Immunity. 2:1995;271-279.
35. Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J.Exp. Med. 185:1997;817-824.
36. Takenaka, H., Mauro, S., Yamamoto, N., Wysocka, M., Ono, S., Kobayashi, M., Yagita, et al. (1997) Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4, J. Leuk. Biol. 61, 80-87.
37. Tone Y., Thompson S.A.J., Babik J.M., Nolan K.F., Tone M., Raven C., Waldmann H. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur. J. Immunol. 26:1996;1222-1227.
38. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood. 84:1994;4008-4027.
39. Warbrick, E.V., Dearman, R.J., Basketter, D.A., Gerberick, G.F., Ryan, C.A., Kimber, I. 1998. Analysis of cytokine mRNA expression following repeated exposure of mice to chemical contact and respiratory allergens, J. Appl. Toxicol. 18, 205-213.
40. Yoshimoto T., Wang C.-R., Yoneto T., Waki S., Sunaga S., Komagata Y., Mitsuyama M. et al. Reduced T helper 1 responses in IL-12 p40 transgenic mice. J. Immunol. 160:1998;588-594.
41. Xu B., Aoyama K., Kitani A., Matsuyama T., Matsushita T. RT-PCR analysis of in vivo cytokine profiles in murine allergic contact dermatitis to DNCB. Toxicol. Methods. 6:1996;23-31.