Transfer of lidocaine across the dual perfused human placental cotyledon

International Journal of Obstetric Anesthesia

Volumn 8, Issue 1, 1999, Pages 17-23

  Johnson, R F ^a,c   Herman, N ^b   Arney, T L ^a   Olenick, M ^a   Paschall, R L ^a   Johnson, H V ^a   Downing, J W ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHENAZONE;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; HUMAN; HUMAN TISSUE; MATERNAL BLOOD; PERFUSION; PLACENTAL TRANSFER; PROTEIN BINDING;

EID: 0032919094     PISSN: 0959289X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-289X(99)80147-2     Document Type: Article

References (20)

1. Reynolds F. Principles of placental drug transfer: its measurement and interpretation. In: Reynolds F, ed. Effects on the Baby of Maternal Analgesia and Anaesthesia. London: W B Saunders, 1993: 4.
2. Wood M. Plasma binding and limitation of drug access to site of action. Anesthesiology 1991; 75: 721-723.
3. Marathe P H, Shen D D, Artru A A, Bowdle T A. Effects of serum protein binding on the entry of lidocaine into brain and cerebrospinal fluid in dogs. Anesthesiology 1991; 75: 804-812.
4. Shnider S M, Way E L. The kinetics of transfer of lidocaine (xylocaine®) across the human placenta. Anesthesiology 1968; 29: 944-950.
5. Morishima H O, Finster M, Pedersen H et al. Pharmacokinetics of lidocaine in fetal and neonatal lambs and adult sheep. Anesthesiology 1979; 50: 431-436.
6. Morishima H O, Covino B G. Toxicity and distribution of lidocaine in nonasphyxiated and asphyxiated baboon fetuses. Anesthesiology 1981; 54: 182-186.
7. Morishima H O, Pedersen H, Santos AC et al. Adverse effects of maternally administered lidocaine on the asphyxiated preterm fetal lamb. Anesthesiology 1989; 71: 110-115.
8. Hamshaw-Thomas A, Reynolds F. Placental transfer of bupivacaine, pethidine and lignocaine in the rabbit. Effect of umbilical flow rate and protein content. Br J Obstet Gynaecol 1985; 92: 706-713.
9. Gaylard D G, Carson R J, Reynolds F. Effect of umbilical perfusate pH and controlled maternal hypotension on placental drug transfer in the rabbit. Anesth Analg 1990; 71: 42-48.
10. Johnson R F, Herman N, Johnson H V, Arney T L, Paschall R L, Downing J W. Effects of fetal pH on local anesthetic transfer across the human placenta. Anesthesiology 1996; 85: 608-615.
11. Johnson R F, Herman N, Arney T L, Gonzalez H, Johnson H V, Downing J W. Bupivacaine transfer across the human term placenta: A study using the human placental model. Anesthesiology 1995; 82: 459-468.
12. Schneider H, Panigel M, Dancis J. Transfer across the perfused human placenta of antipyrine, sodium, and leucine. Am J Obstet Gynecol 1972; 114: 822-828.
13. Brandes J M, Tavolini N, Potter B J, Sarkozi L, Shepard M D, Berk P D. A new recycling technique for the human placental cotyledon perfusion: application to the studies of the fetomaternal transfer of glucose, insulin and antipyrine. Am J Obstet Gynecol 1983; 146: 800-806.
14. Ha H R, Funk B, Gerber H R, Follath F. Determination of bupivacaine in plasma by high-performance liquid chromatography. Anesth Analg 1984; 63: 448-450.
15. Hill M D, Abramson F P. The significance of plasma protein binding on the fetal/maternal distribution of drugs at steady-state. Clin Pharmacokinet 1988; 14: 156-170.
16. Herman N, Van Decar T K, Jones D, Knape K G, Downing J W. Transfer of methohexital across the perfused human placenta. Anesthesiology 1993; 79: A1008.
17. Schenker S, Johnson R F, King T S, Schenken R S, Henderson G I. Azidothymidine (Zidovudine) transport by the human placenta. Am J Med Sci 1990; 299:16-20.
18. Schenker S, Dicke J, Johnson R F, Mor L, Henderson G I. Human placental transport of cimetidine. J Clin Invest 1987; 80: 1428-1434.
19. Dicke J M, Johnson R F, Henderson G I, Kuehl T J, Schenker S. A comparative evaluation of the transport of H2-receptor antagonists by the human and baboon placenta. Am J Med Sci 1988; 295: 198-206.
20. Wood M. Local anesthetic agents. In: Wood M, Wood AJ, eds. Drugs and Anesthesia: Pharmacology for Anesthesiologists. Baltimore: Williams and Wilkins, 1982:349.