Selective antibody neutralization prevents neuropathogenic lactate dehydrogenase-elevating virus from causing paralytic disease in immunocompetent mice

Journal of NeuroVirology

Volumn 5, Issue 2, 1999, Pages 200-208

  Chen, Zongyu ^a   Li, Kehan ^a   Rowland, Raymond R R ^b   Plagemann, Peter G W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b SOUTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

LDV; Neutralizing antibody; Paralytic disease

Indexed keywords

MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNE SYSTEM; LACTIC DEHYDROGENASE TOGAVIRUS; MACROPHAGE; MOTONEURON; MOUSE; NEUROPATHOLOGY; NONHUMAN; PARALYSIS; POLIOMYELITIS; PRIORITY JOURNAL; SPINAL CORD NERVE CELL; SPINAL CORD VENTRAL HORN; TIME; VIRUS REPLICATION;

ANIMALIA; LACTATE DEHYDROGENASE-ELEVATING VIRUS; MURINAE; MUS MUSCULUS; TOGAVIRIDAE;

EID: 0032918690     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550289909022003     Document Type: Article

References (28)

1. Anderson GW, Even C, Rowland RRR, Palmer GA, Harty JT, Plagemann PGW (1995a). C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age. J Neurovirol 1: 244-252.
2. Anderson GW, Palmer GA, Rowland RRR, Even C, Plagemann PGW (1995b). Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in utero infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus. J Virol 69: 308-319.
3. Anderson GW, Palmer GA, Rowland RRR, Even C, Plagemann PGW (1995c). Lactate dehydrogenase-elevating virus entry into central nervous system, and replication in anterior horn neurons. J Gen Virol 76: 581-592.
4. Brinton MA, Cavin EI, Weibel J (1986). Detection of viral-specific nucleic acid and intracellular virions in ventral horn neurons of lactate dehydrogenase-elevating virus infected C58 mice. Microb Pathogen 1: 595-602.
5. Brinton-Darnell M, Plagemann PGW (1975). Structural and chemical-physical characteristics of lactate dehydrogenase-elevating virus and its RNA. J Virol 16: 420-433.
6. Cafruny WA, Chan SPK, Harty JT, Yousefi S, Kowalchyk K, McDonald D, Foreman B, Budweg G, Plagemann PGW (1986). Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus. Virus Res 5: 357-375.
7. γ. Antiviral Res 36: 1-9.
8. Chen Z, Plagemann PGW (1997). Detection of lactate dehydrogenase-elevating virus in transplantable mouse tumors by biological assay and RT-PCR assays and its removal from the tumor cells. J Virol Meth 65: 227-236.
9. Chen Z, Rowland RRR, Anderson GW, Plagemann PGW (1997). Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection. J Virol 71: 2913-2920.
10. Chen Z, Li K, Rowland RRR, Anderson GW, Plagemann PGW (1998). Lactate dehydrogenase-elevating virus variants: cosegregation of neuropathogenicity and impaired ability for high viremic persistent infection. J Neurovirol In press.
11. Coutelier JP, van Snick J (1988). Neutralization and sensitization of lactate dehydrogenase-elevating virus with monoclonal antibodies. J Gen Virol 69: 2097-2100.
12. Faaberg KS, Plagemann PGW (1995). The envelope proteins of lactate dehydrogenase-elevating virus and their membrane topography. Virology 212: 512-525.
13. Faaberg KS, Even C, Palmer GA, Plagemann PGW (1995a). Disulfide bonds between two envelope proteins of lactate dehydrogenase-elevating virus are essential for viral infectivity. J Virol 69: 613-617.
14. Faaberg KS, Palmer GA, Even C, Anderson GW, Plagemann PGW (1995b). Differential glycosylation of the ectodomain of the primary envelope glycoprotein of two strains of lactate dehydrogenase-elevating virus that differ in neuropathogenicity. Virus Res 39: 331-340.
15. Harty JT, Plagemann PGW (1988). Formalin inactivation of the lactate dehydrogenase-elevating virus reveals a major neutralizing epitope not recognized during natural infection. J Virol 62: 3210-3216.
16. Harty JT, Plagemann PGW (1990). Monoclonal antibody protection from age-dependent poliomyelitis: Implications regarding the pathogenesis of lactate dehydrogenase-elevating virus. J Virol 64: 6257-6262.
17. Harty JT, Chan SPK, Contag CH, Plagemann PGW (1987). Protection of C58 mice from lactate dehydrogenase-elevating virus-induced motor neuron disease by non-neutralizing antiviral antibodies without interference with virus replication. J Neuroimmunol 15: 195-206.
18. Li K, Chen Z, Plagemann PGW (1998). The neutralization epitope of lactate dehydrogenase-elevating virus is located on the short ectodomain of the primary envelope glycoprotein. Virology 242: 239-245.
19. Murphy WH, Nawrocki JF, Pease LR (1983). Agedependent paralytic viral infection in C58 mice: Possible implication in human neurologic disease. Prog Brain Res 59: 291-303.
20. Murphy WH, Mazur JJ, Fulton SA (1987). Animal model for motor neuron disease. In Clinical Neuroimmunology, pp 135-155. Edited by WMH Behan, PO Behan & JA Aarli. Oxford, England: Blackwell Scientific Publications.
21. Onyekaba CO, Harty JT, Plagemann PGW (1989). Extensive cytocidal replication of lactate dehydrogenase-elevating virus in cultured peritoneal macrophages from 1- and 2-week-old mice. Virus Res 14: 327-338.
22. Plagemann PGW (1996). Lactate dehydrogenase-elevating virus and related viruses. In Virology. 3rd Edition. Fields BN, Knipe DM and Howley PM (eds.) Raven Press, New York, pp 1105-1120.
23. Plagemann PGW, Moennig V (1992). Lactate dehydrogenase-elevating virus, equine arteritis virus and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses. Adv Virus Res 41: 99-192.
24. Plagemann PGW, Gregory KF, Swim HE, Chan KKW (1963). Plasma lactic dehydrogenase elevating agent of mice. Distribution in tissues and effect our lactate dehydrogenase isozyme patterns. Can J Microbiol 9: 75-86.
25. Plagemann PGW, Harty JT, Even C (1992). Mode of neutralization of lactate dehydrogenase-elevating virus by polyclonal and monoclonal antibodies. Arch Virol 123: 89-100.
26. Plagemann PGW, Rowland RRR, Even C, Faaberg KS (1995). Lactate dehydrogenase-elevating virus - an ideal persistent virus? Semin Immunopathol 17: 167-186.
27. Rowson KEK, Mahy BWJ (1975). Lactic dehydrogenase virus. Virol Monog 13: Springer Verlag, Wien.
28. Stueckemann JA, Ritzi DM, Holth M, Smith MS, Swart WJ, Cafruny WA, Plagemann PGW (1982). Replication of lactate dehydrogenase-elevating virus in macrophages. 1. Evidence for cytocidal replication. J Gen Virol 59: 245-262.