Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 4, 1999, Pages 937-939

  Hernández Allés, Santiago ^a   Benedí, Vicente J ^a   Martínez Martínez, Luis ^b   Pascual, Álvaro ^b   Aguilar, Alicia ^c   Tomás, Juan M ^c   Albertí, Sebastián ^a,d  

^a INSTITUTO MEDITERRÁNEO DE ESTUDIOS AVANZADOS   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CEFOXITIN; CEPHALOSPORIN; PORIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIUM ISOLATE; GENE EXPRESSION; GENE INSERTION SEQUENCE; KLEBSIELLA PNEUMONIAE; PRIORITY JOURNAL;

EID: 0032918655     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.4.937     Document Type: Article

References (20)

1. Aggeler, R., R. Then, and R. Ghosh. 1987. Reduced expression of outer-membrane proteins in β-lactam-resistant mutants of Enterobacter cloacae. J. Gen. Microbiol. 133:3383-3392.
2. Albertí, S., F. Rodríguez-Quiñones, T. Schirmer, G. Rummel, J. M. Tomás, J. P. Rosenbusch, and V. J. Benedí. 1995. A porin from Klebsiella pneumoniae: sequence homology, three-dimensional structure, and complement binding. Infect. Immun. 63:903-910.
3. Ardanuy, C., J. Lińares, M. A. Domínguez, S. Hernández-Allés, V. J. Benedí, and L. Martínez-Martínez. 1998. Outer membrane profiles of clonally related Klebsiella pneumoniae isolated from clinical samples and activity of cephalosporins and carbapenems. Antimicrob. Agents Chemother. 42:1636-1640.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1997. Current protocols in molecular biology. Wiley Interscience, New York, N.Y.
5. Filip, C., G. Fletcher, J. L. Wulf, and C. F. Earhart. 1973. Solubilization of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium-lauryl sarcosinate. J. Bacteriol. 115:717-722.
6. Hernández-Allés, S., S. Albertí, D. Alvarez, A. Doménech-Sánchez, L. Martínez-Martínez, J. Gil, J. M. Tomás, and V. J. Benedí. 1999. Porin expression in clinical isolates of Klebsiella pneumoniae. Microbiology 145:673-679.
7. Hernández-Allés, S., S. Albertí, X. Rubirés, S. Merino, J. M. Tomás, and V. J. Benedí. 1996. Isolation of FC3-11, a bacteriophage specific for the Klebsiella pneumoniae porin OmpK36, and its use for the isolation of porin-deficient mutants. Can. J. Microbiol. 41:399-406.
8. Jaurin, B., and S. Normark. 1983. Insertion of IS2 creates a novel ampC promoter in Escherichia coli. Cell 32:809-816.
9. Martínez-Martínez, L., S. Hernández-Allés, S. Albertí, J. M. Tomás, V. J. Benedí, and G. A. Jacoby. 1996. In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum cephalosporins. Antimicrob. Agents Chemother. 40:342-348.
10. Medeiros, A. A., T. F. O'Brien, E. Y. Rosenberg, and H. Nikaido. 1987. Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to chephalosporins during therapy. J. Infect. Dis. 156:751-757.
11. Meyer, K. S., C. Urban, J. A. Eagan, B. J. Berger, and J. J. Rahal. 1993. Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. Ann. Intern. Med. 119:353-358.
12. Nikaido, H. 1989. Outer membrane barrier as a mechanism of antimicrobial resistance. Antimicrob. Agents Chemother. 33:1831-1836.
13. Ozawa, Y., S. Mizushima, and T. Mizuno. 1990. Osmoregulatory expression of the ompC gene in Escherichia coli K-12; IS1 insertion in the upstream regulatory region results in constitutive activation of the promoter. FEMS Microbiol. Lett. 68:295-300.
14. Philippon, A., R. Labia, and G. A. Jacoby. 1989. Extended-spectrum β-lactamases. Antimicrob. Agents Chemother. 33:1131-1136.
15. Podglajen, I., J. Breuil, and E. Collatz. 1994. Insertion of a novel DNA sequence, IS1186, upstream of the silent carbapenemase gene cfiA, promotes expression of carbapenem resistance in clinical isolates of Bacteroides fragilis. Mol. Microbiol. 12:105-114.
16. E. J. Bacteriol. 180:3388-3392.
17. Rice, L. B., S. H. Willey, A. Papanicolau, A. A. Medeiros, G. M. Eliopoulos, R. C. Moellering, and G. A. Jacoby. 1990. Outbreak of ceftazidime resistance caused by extended-spectrum β-lactamases at a Massachusetts chronic-care facility. Antimicrob. Agents Chemother. 34:2193-2199.
18. Syvanen, M. 1984. The evolutionary implications of mobile genetic elements. Annu. Rev. Genet. 18:271-293.
19. van de Klundert, J. A. M., M. H. van Gestel, G. Meerdink, and S. de Marie. 1988. Emergence of bacterial resistance to cefamandole in vivo due to outer membrane protein deficiency. Eur. J. Clin. Microbiol. Infect. Dis. 7:776-777.
20. Yoneyama, H., and T. Nakae. 1993. Mechanism of efficient elimination of protein D2 in outer membrane of imipenem-resistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 37:2385-2390.