Comparison of the clearance of radiolabelled nose drops and nasal spray as mucosally delivered vaccine

Nuclear Medicine Communications

Volumn 20, Issue 2, 1999, Pages 171-174

  Bryant, M L ^a   Brown, P ^a   Gurevich, N ^b   McDougall, I R ^b  

^a MEDIMMUNE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN TC 99M; INFLUENZA VACCINE; NOSE DROPS; NOSE SPRAY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FEMALE; GAMMA SCINTIGRAPHY; HUMAN; INFLUENZA VACCINATION; INTRANASAL DRUG ADMINISTRATION; MALE; NORMAL HUMAN;

EID: 0032917545     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1080/00006231-199902000-00010     Document Type: Article

References (6)

1. Hughes BL, Allen DL, Dora to MA, Wolff RK. Effect of delivery devices on nasal deposition and mucociliary clearance in Rhesus monkeys. Aerosol Sei Tech 1993; 18: 241-249.
2. Hardy JG, Lee SW, Wilson CG. Intranasal drug delivery by spray and drops. J Pharm Pharmacol 1985; 37: 294-297.
3. Harris AS, Nilsson IM, Wagner ZG, Alkner U. Intranasal administration of peptides: Nasal deposition, biological response, and absorption of desmopression. J Pharm Sei 1986; 11: 1085-1088.
4. Wolff RK, Allen DL, Hughes BL, Osier M, Dorato MA. Nasal clearance in Rhesus monkeys. J Aerosol Med 1993; 6: 111-119.
5. Gruber WC, Hinson P, Holland KL, Thompson JM, Reed GW, Wright PF. Comparative trial of large-particle aerosol and nose drops administration of live attenuated influenza vaccines. J Infect Dis 1993; 168: 1282-1285.
6. King Jr. JC, Lagos R, Bernstein DL et al. Safety and immuno-genicity of low and high doses of trivalent live cold-adapted influenza vaccine administered intranasally as drops or spray to healthy children. J Infect Dis 1998; 177: 1394-1397.