Biosynthesis of the pyrimidine moiety of thiamine independent of the PurF enzyme (phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium: Incorporation of stable isotope-labeled glycine and formate

Journal of Bacteriology

Volumn 181, Issue 3, 1999, Pages 841-848

  Enos Berlage, Jodi L ^a   Downs, Diana M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDOPHOSPHORIBOSYLTRANSFERASE; BACTERIAL ENZYME; CARBON 13; COCARBOXYLASE; FORMIC ACID; GLYCINE; ISOTOPE; MUTANT PROTEIN; PYRIMIDINE; THIAMINE; THIAMINE PHOSPHATE;

ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PURINE SYNTHESIS; PYRIMIDINE SYNTHESIS; SALMONELLA TYPHIMURIUM;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; NEPTUNIA; PROKARYOTA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032916516     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.3.841-848.1999     Document Type: Article

References (37)

1. Beck, B. J., and D. M. Downs. 1998. The apbE gene encodes a lipoprotein involved in thiamine biosynthesis in Salmonella typhimurium. J. Bacteriol. 180:885-891.
2. Berkowitz, D., J. M. Hushon, H. J. Whitfield, J. Roth, and B. N. Ames. 1968. Procedure for identifying nonsense mutations. J. Bacteriol. 96:215-220.
3. Dalal, F. R., R. E. Gots, and J. E. Gots. 1966. Mechanism of adenine inhibition in adenine-sensitive mutants of Salmonella typhimurium. J. Bacteriol. 91:507-513.
4. 4]-1-deoxy-D-threo-2-pentulose and incorporation of this sugar in biosynthesis of thiazole by Escherichia coli cells. J. Chem. Soc. Perkin Trans. 1:2131-2137.
5. David, S., J.-C. Estramareix, and M. Therisod. 1981. 1-Deoxy-D-threo-2-pentulose: the precursor of the five-carbon chain of the thiazole of thiamine. J. Am. Chem. Soc. 103:7341-7342.
6. DeMoll, E., and W. Shive. 1985. Determination of the metabolic origin of the sulfur atom in thiamine of Escherichia coli by mass spectrometry. Biochem. Biophys. Res. Commun. 132:217-222.
7. Downs, D. M. 1992. Evidence for a new, oxygen-regulated biosynthetic pathway for the pyrimidine moiety of thiamine in Salmonella typhimurium. J. Bacteriol. 174:1515-1521.
8. Downs, D. M., and L. Petersen. 1994. apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium. J. Bacteriol. 176:4858-4864.
9. Downs, D. M., and J. R. Roth. 1991. Synthesis of thiamine in Salmonella typhimurium independent of the purF function. J. Bacteriol. 173:6597-6604.
10. Enos-Berlage, J. L. 1998. Characterization of thiamine-pyrophosphate synthesis independent of the PurF enzyme (phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium. Ph.D. thesis. University of Wisconsin - Madison, Madison.
11. Enos-Berlage, J. L., and D. M. Downs. 1996. Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium. J. Bacteriol. 178:1476-1479.
12. Enos-Berlage, J. L., and D. M. Downs. 1997. Mutations in sdh (succinate dehydrogenase genes) alter the thiamine requirement of Salmonella typhimurium. J. Bacteriol. 179:3989-3996.
13. Estramareix, B., and S. David. 1990. Conversion of 5-aminoimidazole ribotide to the pyrimidine of thiamine in enterobacteria: study of the pathway with specifically labeled samples of riboside. Biochim. Biophys. Acta 1035: 134-160.
14. Estramareix, B., and M. Lesieur. 1969. Biosynthesis of the pyrimidine moiety of thiamine: origin of carbons in positions 2 and 4 in Salmonella typhimurium. Biochim. Biophys. Acta 192:375-377.
15. Estramareix, B., and M. Therisod. 1984. Biosynthesis of thiamine: 5-amino-imidazole ribotide as the precursor of all the carbon atoms of the pyrimidine moiety. J. Am. Chem. Soc. 106:3857-3860.
16. Estramareix, B., and M. Therisod. 1972. Tyrosine as a factor in biosynthesis of the thiazole moiety of thiamine in Escherichia coli. Biochim. Biophys. Acta 273:275-282.
17. Frodyma, M. E., and D. M. Downs. 1998. The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. J. Bacteriol. 180:4757-4759.
18. Gots, J. S. 1971. Regulation of purine and pyrimidine metabolism, p. 225-254. In H. J. Vogel (ed.). Metabolic regulation, vol. V. Academic Press. New York, N.Y.
19. Kawasaki, T. 1986. Determination of thiamine and its phosphate esters by high-performance liquid chromatography, p. 15-29. In F. Chytil and D. B. McCormick (ed.). Vitamins and coenzymes, part G, vol. 122. Academic Press, Inc., New York, N.Y.
20. Kumaoka, H., and G. Brown. 1967. Biosynthesis of thiamine: incorporation of formate into carbon atom two of the pyrimidine moiety of thiamine. Arch. Biochem. Biophys. 122:378-384.
21. Messenger, L. J., and H. Zalkin. 1979. Glutamine phosphoribosyl pyrophosphate amidotransferase from Escherichia coli. J. Biol. Chem. 254:3382-3392.
22. Newell, P. C., and R. G. Tucker. 1968. Biosynthesis of the pyrimidine moiety of thiamine. Biochem. J. 106:279-287.
23. Newell, P. C., and R. G. Tucker. 1967. New pyrimidine pathway involved in the biosynthesis of the pyrimidine of thiamine. Nature (London) 215:1384-1385.
24. Newell, P. C., and R. G. Tucker. 1968. Precursors of the pyrimidine moiety of thiamine. Biochem. J. 106:271-277.
25. Nosaka, K., Y. Kaneko, H. Nishimura, and A. Iwashima. 1993. Isolation and characterization of a thiamine pyrophosphokinase gene, thi80, from Saccharomyces cerevisiae. J. Biol. Chem. 268:17440-17447.
26. Nygaard, P., and J. M. Smith. 1993. Evidence for a novel glycinamide ribonucleotide transformylase in Escherichia coli. J. Bacteriol. 175:3591-3597.
27. Petersen, L. A., J. L. Enos-Berlage, and D. M. Downs. 1996. Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium. Genetics 143:37-44.
28. Rolfes, R. J., and H. Zalkin. 1988. Escherichia coli gene purR encoding a repressor protein for purine nucleotide synthesis. J. Biol. Chem. 263:19653-19661.
29. Stauffer, G. V. 1996. Biosynthesis of serine, glycine, and one-carbon units, p. 506-513. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed., vol. 1. ASM Press, Washington, D.C.
30. Steiert, J. G., R. J. Rolfes, H. Zalkin, and G. V. Stauffer. 1990. Regulation of Escherichia coli glyA gene by the purR gene product. J. Bacteriol. 172:3799-3830.
31. Van Dyk, T. K., and R. A. LaRossa. 1990. Prevention of endogenous 2-ketobutyrate toxicily in Salmonella typhimurium, p. 123-130. In Z. Barak, D. M. Chipman, and J. V. Schloss (ed.), Biosynthesis of branched amino acids. VCH and Balglan Publishers, Weinheim, Germany.
32. Webb, E., and D. M. Downs. 1997. Characterization of thiL, encoding thiamine monophosphate kinase, in Salmonella typhimurium. J. Biol. Chem. 252:15702-15707.
33. Webb, E., F. Febres, and D. M. Downs. 1996. Thiamine pyrophosphate negatively regulates transcription of some thi genes of Salmonella typhimurium. J. Bacteriol. 178:2533-2538.
34. Weber, S., and D. M. Downs. 1998. Unpublished results.
35. White, R. H., and F. B. Rudolph. 1979. Biosynthesis of the pyrimidine moiety of thiamine in Escherichia coli: incorporation of stable isotope-labeled glycines. Biochemistry 18:2632-2636.
36. Zilles, J. L., and D. M. Downs. 1996. A novel involvement of the PurG and PurI proteins in thiamine synthesis via the alternative pyrimidine biosynthetic (APB) pathway in Salmonella typhimurium. Genetics 144:883-892.
37. Zilles, J. L., and D. M. Downs. 1998. Unpublished data.