A microcarrier-based cell culture process for the production of a bovine respiratory syncytial virus vaccine

Cytotechnology

Volumn 29, Issue 2, 1999, Pages 135-149

  Moran, Enda ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b MFM Laboratories Ltd   (United Kingdom)

Author keywords

Anchorage dependent; Animal cell; Bioreactor; Cultispher S; Cytodex 3; Microcarrier; Respiratory syncytial virus; Vaccine

Indexed keywords

BIOREACTOR; CELL CULTURE; CELL DENSITY; CELL GROWTH; CELL LINE; MICROCARRIER; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VACCINE PRODUCTION; VIRUS INFECTION;

ANIMALIA; BOVINAE; BOVINE RESPIRATORY SYNCYTIAL VIRUS; MAMMALIA; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS; SYNCYTIAL VIRUS; VISCUM ALBUM;

EID: 0032914212     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008022828736     Document Type: Article

References (29)

1. Aunins JG, Croughan MS, Wang DIC and Goldstein JM (1986) Effects of paddle impeller geometry on power input and mass transfer in small scale animal cell culture vessels. Biotechnol Bioeng 34: 1127-1132.
2. Barteling SJ and Vreewijk J (1991) Development of foot and mouth disease vaccines. Vaccine 9: 75-88.
3. Chun B-H, Park S-Y and Moon H-M (1996) Production of live attenuated varicella-zoster virus in human embryonic lung cells using microcarrier. Biotechnol Tech 10: 151-156.
4. Clark JM and Hirtenstein MD (1981) Optimizing culture conditions for the production of animal cells in microcarrier culture. Ann NY Acad Sci 369: 33-46.
5. Croughan MS, Hamel J-FP and Wang DIC (1988) Effects of microcarrier concentration in animal cell culture. Biotechnol. Bioeng 32: 957-982.
6. Croughan MS and Wang DIC (1989) Growth and death in overagitated microcarrier cell cultures. Biotechnol Bioeng 33: 731-744.
7. Duvar S, Muthing J, Mohr H and Lehmann J (1991) Scale-up cultivation of primary human umbilical vein endothelial cells on microcarriers from spinner vessels to bioreactor fermentation. Cytotechnology 21: 61-72.
8. Fenner F, Bachmann PA, Gibbs EPJ, Murphy FA, Studdert MJ and White DO (1987) Veterinary Virology. Academic Press, Inc., London.
9. Fleischaker RJ and Sinskey AJ (1981) Oxygen demand and supply in cell culture. Eur J Appl Microbiol Biotechnol 12: 193-197.
10. Hayle AJ (1986) Culture of respiratory syncytial virus infected diploid bovine nasal mucosa cells on Cytodex 3 microcarriers. Arch Virol 89: 81-88.
11. Holland JJ, Villarreal LP, Welsh RM, Oldstone MBA, Kohne D, Lazzarini R and Scolnick E (1976) Long-term persistent vesicular stomatitis virus and rabies infection of cells in vitro. J Gen Virol 33: 193-211.
12. Howard CJ, Stott EJ, Thomas LH, Taylor G and Gourlay RN (1987) Protection against respiratory disease in calves induced by vaccines containing respiratory syncytial virus, parainfluenza type 3 virus, Mycoplasma bovis and M dispar. Vet. Record 121: 372-376.
13. Long B (1994) The Production and Regulation of Veterinary Virus Vaccines. In: Animal Cell Biotechnology. Vol. 6. (pp 281-313) Academic Press Ltd., London.
14. Miller WM, Wilke CR and Blanch HW (1988) Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture. Bioprocess Eng 3: 101-111.
15. Miller WM, Wilke CR and Blanch HW (1989) Transient responses of hybridoma cells to nutrient additions in continuous culture: I. Glucose pulse and step changes. Biotechnol Bioeng 33: 477-486.
16. Montagnon BJ, Vincent Falguet JC and Janget B (1983) Thousand litre scale microcarrier culture of Vero cells for killed polio virus vaccine. Promising results. Dev Biol Stand 55: 37-42.
17. Ng Y-C, Berry JM and Butler M (1996) Optimization of physical parameters for cell attachment and growth on macroporous microcarriers. Biotechnol Bioeng 50: 627-635.
18. Ohlson S, Branscomb J and Nilsson K (1994) Bead-to-bead transfer of Chinese hamster ovary cells using macroporous microcarriers. Cytotechnology 14: 67-80.
19. Onuma M, Hodatsu T, Yamamoto S, Higashihara M, Masu S, Mikami T and Izawa H (1984) Protection by vaccination against bovine leukemia virus infection in sheep. Am J Vet Res 45: 1212-1215.
20. Pringle CR, Shirodaria PV, Cash P, Chiswell DJ and Malloy P (1978) Initiation and maintenance of a persistent infection by respiratory syncytial virus. J Virol 28: 199-211.
21. Reitzer LJ, Wice BM and Kennel D (1979) Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 254: 2669-2676.
22. Rima BK and Martin SJ (1976) Persistent infection of tissue culture cells by RNA viruses. Med Microbiol Immunol 162: 89-118.
23. Stott EJ, Thomas LH, Taylor G, Collins AP, Jebbett J and Crouch S (1984) A comparison of three vaccines against respiratory syncytial virus in calves. J Hyg 93: 251-261.
24. Taylor G, Stott EJ, Bew M, Fernie BF, Cote PJ, Collins AP, Hughes M and Jebbett J (1984) Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunology 52: 137-142.
25. Thomas LH, Gourlay RN, Stott EJ, Howard CJ and Bridger JC (1982) A search for new microorganisms in calf pneumonia by the inoculation of gnotobiotic calves. Res Vet Sci 33: 170-182.
26. Van der Velden-de Groot CAM (1995) Microcarrier technology, present status and perspective. Cytotechnology 18: 51-56.
27. Van Wezel AL, Van der Velden-de Groot CAM and Van Herwaarden JAM (1980) The production of inactivated polio vaccine on serially cultivated kidney cells from captive bred monkeys. Dev Biol Stand 46: 151-158.
28. Varani J, Josephs S and Hillegas WJ (1996) Human diploid fibroblast growth on polystyrene microcarriers in aggregates. Cytotechnology 22: 111-117.
29. Zielke HR, Ozand PT, Tildon JT, Sevdalian DA and Cornblath M (1978) Reciprocal regulation of glucose and glutamine utilisation by cultured diploid fibroblasts. J Cell Physiol 95: 41-48.