Independent signal-transduction pathways for vanadate and for insulin in the activation of glycogen synthase and glycogenesis in rat adipocytes

Endocrinology

Volumn 140, Issue 3, 1999, Pages 1125-1131

  Sekar, Natesampillai ^a   Li, Jinping ^a   He, Zehibin ^a   Gefel, Dov ^b   Shechter, Yoram ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b BARZILAI MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATASE; GLYCOGEN SYNTHASE; INSULIN; VANADIC ACID;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; GLYCOGEN SYNTHESIS; HORMONAL REGULATION; HORMONE ACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032914074     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.3.6560     Document Type: Article

References (55)

1. 1. Shechter Y, Karlish SJD 1980 Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl(IV) ions. Nature 284:556-558
2. +)ATPase inhibitor. J Biol Chem 255:5306-5312
3. 3. Degani H, Gochin M, Karlish SJD, Shechter Y 1981 Electron paramagnetic resonance studies and insulin-like effects of vanadium in rat adipocytes. Biochemistry 20:5795-5799
4. 4. Shechter Y, Ron A 1986 Effect of depletion of phosphate and bicarbonate ions on insulin action in rat adipocytes. J Biol Chem 261:14951-14954
5. 5. Meyerovitch J, Farfel Z, Sack Y, Shechter Y 1987 Oral administration of vandaate normalized blood glucose levels in streptozotocin-treated rats: characterization and mode of action. J Biol Chem 262:6658-6662
6. 6. Heyliger CE, Tahiliani AG, McNeill JH 1985 Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science 227:1474-1476
7. 7. Miralpeix M, Decaux J, Kahn A, Bartrons R 1991 Vanadate induction of L-type pyruvate kinase mRNA in adult rat hepatocytes in primary culture. Diabetes 40:462-464
8. 8. Shechter Y 1990 Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. Diabetes 39:1-5
9. 9. Shechter Y, Li J, Meyerovitch J, Gefel D, Bruck R, Elberg G, Miller DS, Shisheva A 1995 Insulin-like actions of vanadate are mediated in an insulin receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases. Mol Cell Biochem 153:39-47
10. 10 Brichard MS, Henquin JC 1995 The role of vanadium in the management of diabetes. Trends Pharmacol Sci 16:265-270
11. 11. Sekar N, Li J, Shechter Y 1996 Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research. Crit Rev Biochem Mol Biol 31:339-359
12. 12. Tamura S, Brown TA, Whipple JH, Yamaguchi YF, Dubler RE, Chen K, Larner J 1984 A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes. J Biol Chem 259:6650-6658
13. 13. Swarup G, Cohen S, Garbers DL 1982 Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem Biophys Res Commun 107:1104-1109
14. 14. Mooney RA, Bordwell KL, Luhowskyj S, Casnellie JE 1989 The insulin-like effect of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation. Endocrinology 124:422-429
15. 15. Strout HV, Vicario PD, Superstein R, Slater EE 1989 The insulin-mimetic effect of vanadate is not correlated with insulin receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo. Endocrinology 124:1918-1924
16. 16 Fantus GI, Kadota S, Deragon G, Foster B, Posner BI 1987 Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase. Biochemistry 28:8864-8871
17. 17. D'Onotrio F, Le MQ, Chiassion JL, Srivastava AK 1994 Activation of mitogen activated protein (MAP) kinases by vanadate is independent of insulin receptor autophosphorylation. FEBS Lett 340:269-275
18. 2 and vanadate enhances insulin receptor phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase. J Cell Biochem 58:279-291
19. 19. Shisheva A, Shechter Y 1992 Quercetin selectively inhibits insulin receptor function in vitro and the bioresponse of insulin and insulinomimetic agents in rat adipocytes. Biochemistry 31:8059-8063
20. 20. Shisheva A, Shechter Y 1992 A cytosolic tyrosine kinase in rat dipocytes. FEBS Lett 300:93-96
21. 21. Shisheva A, Shechter Y 1993 Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes. J Biol Chem 268:6463-6469
22. 22. Elberg G, Li J, Shechter Y 1994 Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiment, depending on its oxidation state. Possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity. J Biol Chem 269:9521-9527
23. 23. Rodbell M 1964 Metabolism of isolated fat cells. I. Effect of hormones on glucose metabolism and lipolysis. J Biol Chem 239:375-380
24. 14C-glucose. Anal Biochem 72:486-499
25. 25. Lawrence JC, Guinovart JJ, Larner J 1977 Activation of rat adipocyte glycogen synthase by insulin. J Biol Chem 252:444-450
26. 26. Hess SL, Suchin CR, Saltiel AR 1991 The specific protein phosphatase inhibitor okadaic acid differentially modulate insulin action. J Cell Biochem 45:374-380
27. 27. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
28. 28. Ames BN 1966 Assay of inorganic phosphate and phosphatases. Methods Enzymol 8:115-118
29. 29. Bickerstaff GF, Burchell B 1980 Studies on the purification of glucose 6-phosphatase from rabbit liver microsomal fraction. Biochem Soc Trans 8:389-390
30. 30. Lang G, Michal G 1974 D-glucose-6-phosphate and D-fructose-6-phosphate. In: Bergmeyer HU (ed) Methods of Enzymatic analysis. Academic Press, New York, vol 3:1238-1242
31. 31. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 46:359-384
32. 32. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M 1994 Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with selective inhibitor wortmannin. J Biol Chem 269:3568-3573
33. 33. Kelly KI, Ruderman NB 1993 Insulin-stimulated phosphatidylinositol 3-kinase association with a 185-kDa tyrosine phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem 268:4391-4398
34. 34. Heller-Harrison RA, Morin MM, Guilherme A, Czech MP 1996 Insulin mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles. J Biol Chem 271:10200-10204
35. 35. Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA 1995 Inhibition of glycogen synthase kinase-3 by insulin mediated protein kinase B. Nature 378:785-789
36. 36. Burgering BMT, Coffer PJ 1995 Protein kinase B (c-Akt) in phospha-tidylinositol 3-OH kinase signal transduction. Nature 376:599-602
37. 37. Li J, Elberg G, Sekar N, He Z, Shechter Y 1997 Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms. Endocrinology 138:2274-2279
38. 38. Dent P, Lavoinne A, Nakienly S, Caudwell FB, Watt F, Cohen P 1990 The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348:302-308
39. 39. Cohen P, Holmes CFB, Tsukitani Y 1990 Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci 15:98-102
40. 40. Haystead TAY, Sim ATR, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG 1989 Effects of tumor promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337:78-81
41. 41. Lawrence JC, James C, Hiken JF 1986 Control of glycogen synthase by insulin and isoproterenol in rat adipocytes: changes in the distribution of phosphate in the synthase subunit in response to insulin and beta-adrenergic receptor activation. J Biol Chem 261:669-677
42. 42. Roach PJ 1986 Liver glycogen synthase. In: Boyer PD, Krebs EG (eds) Enzymes, ed 3. Academic Press, New York, vol 17:499-539
43. 43. Villar-Palasi C 1991 Substrate specific activation by glucose 6-phosphate on the dephosphorylation of muscle glycogen synthase. Biochim Biophys Acta 1244:203-208
44. 44. Lima BP, Bao S, Garvey WT 1994 Biological actions of insulin are differentially regulated by glucose and insulin in primary cultured adipocytes. Chronic ability to increase glycogen synthase activity. Diabetes 43:53-62
45. 45. Blondel O, Simon J, Chevalier B, Portha B 1990 Impaired insulin action but normal insulin receptor activity in diabetic rat liver: effect of vanadate. Am J Physiol 258:E459-E467
46. 46. Gil J, Miralpeix M, Carreras J, Bartrons R 1988 Insulin-like effects of vanadate on glucokinase activity and fructose 2,6 biphosphate levels in the liver of diabetic rats. J Biol Chem 263:1868-1871
47. 47. Bollen M, Miralpeix M, Ventura F, Toth B, Bartrons R, Stalmans W 1990 Oral administration of vanadate to streptozotocin-diabetic rats restores the glucose-induced activation of liver glycogen synthase. Biochem J 267:269-271
48. 48. Venkatesan N, Avidan A, Davidson MB 1991 Antidiabetic action of vanadyl in rats independent of in vivo insulin-receptor kinase activity. Diabetes 40:492-498
49. 49. Rossetti L, Laughlin MR 1989 Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalized, in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle. J Clin Invest 84:892-899
50. 50. Green A 1986 The insulin-like effect of sodium vanadate on adipocyte glucose transport is mediated at a post-insulin-receptor level. Biochem J 238:663-669
51. 51. Elberg G, He Z, Li J, Sekar N, Shechter Y 1997 Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes. Diabetes 46:1684-1690
52. 52. Singh J, Nordlie CR, Jorgenson RA 1981 Vanadate, a potent inhibitor of multifunctional glucose-6-phosphatase. Biochim Biophys Acta 678:477-482
53. 53. Sekar N, Li J, He Z, Shechter Y 1997 A novel assay for evaluating glycogenolysis in rat adipocytes and the inability of insulin to antagonize glycogenolysis in this cell type. Biochemistry 36:16206-16211
54. 54. McLean B, Greenbaum AL 1968 In: Dickens F, Whelan WJ, Randle PJ (eds) Handbook of Biochemistry. Academic Press, London and New York, pp 397-425
55. 55. Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rossetti L 1995 Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 95:2501-2509