The in vitro hepatic microsomal metabolism of 3,5-dimethyl-4- (phenylazo)-(1H)-pyrazole in rats

Drug Metabolism and Drug Interactions

Volumn 15, Issue 2-3, 1999, Pages 107-114

  Kaymakcioglu B ^a   Oruc E ^a   Ulgen, M ^a   Rollas, S ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

Azopyrazole; In vitro metabolism; Microsomes; Rat

Indexed keywords

3,5 DIMETHYL 4 AMINO 1H PYRAZOLE; 3,5 DIMETHYL 4 PHENYLAZO 1H PYRAZOLE; 3,5 DIMETHYL 4 PHENYLAZOXY 1H PYRAZOLE; ACETIC ACID; ACETONITRILE; ACETYLACETONE; ALCOHOL; AZO COMPOUND; CARCINOGEN; DIAZONIUM COMPOUND; ETHER; HYDRAZINE; HYDROGEN PEROXIDE; PYRAZOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; CHEMICAL STRUCTURE; CONFERENCE PAPER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; RAT; REACTION ANALYSIS; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0032913256     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.1999.15.2-3.107     Document Type: Conference Paper

References (10)

1. Zbaida S. The mechanism of microsomal azo reduction: Predictions based on electronic aspects of structure-activity relationships. Drug Metab Rev 1995; 27: 497-516.
2. Levine WG. Metabolism of azo dyes: Implication for detoxication and activation. Drug Metab Rev 1991; 23: 253-309.
3. Koh MH, Gorrod JW. In vitro metabolic N-oxidation of azo compounds I. Evidence for formation of azo N-oxides (azoxy compounds). Drug Metab Drug Interact 1989; 7: 253-272.
4. Mitchard M. Bioreduction of organic nitrogen. Xenobiotica 1971; 1: 469-481.
5. Koh MH, Gorrod JW. In vitro metabolic N-oxidation of azo compounds III. Effect of various potential inhibitors, activators and inducers on N-oxidation. J Biopharm Sci 1990; 1: 191-204.
6. Dunn DL, Lubet RA, Prough RA. Oxidative metabolism of N-isopropyl-α-(2-methylhydrazino)-p-toluamide HC1 (procarbazine) by rat liver microsomes. Cancer Res 1979; 39: 4555-4563.
7. Wiebkin P, Prough RA Oxidative metabolism of N-isopropyl-α-(2-methyl-azo)-p-toluamide (azoprocarbazine) by rodent liver microsomes. Cancer Res 1980; 40: 3524-3529.
8. Ergenç N, Rollas S. Some azopyrazoles I. J Pharm Fac Ist 1975; 11: 138-157.
9. Richter V. The Chemistry of the Carbon Compounds. Volume III. The Aromatic Compounds. New York: Elsevier, 1946; 133-135.
10. Schenkman JB, Cinti DL. Preparation of microsomes with calcium. Meth Enzymol 1978; 52: 83-85.