Evaluation of effects of ethyl alcohol and bismuth subsalicylate on gastric mucosal barrier in man

Digestive Diseases and Sciences

Volumn 44, Issue 2, 1999, Pages 286-289

  Dy, Robert M ^a   Lof, John ^a   DiBaise, John K ^a   Quigley, Eamonn M M ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Bismuth subsalicylate; Ethyl alcohol; Gastric mucosal defense; Juxtamucosal pH gradient; Mucus bicarbonate barrier

Indexed keywords

ALCOHOL; BISMUTH SALICYLATE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTRITIS; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH MUCOSA; STOMACH MUCOSA LESION; STOMACH MUCUS; STOMACH PH;

EID: 0032913253     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026694131809     Document Type: Article

References (22)

1. 1. Williams SE, Turnberg LA: Retardation of acid diffusion by pig gastric mucosa: A potential role in mucosal protection. Gastroenterology 79:299-304, 1980
2. 2. Pfeiffer CJ: Experimental analysis of hydrogen ion diffusion in gastrointestinal mucus glycoprotein. Am J Physiol 240:G176-G182, 1981
3. 3. Williams SE, Turnberg LA: The demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a "mucus-bicarbonate barrier." Gut 22:94-96, 1981
4. 4. Flemstrom G, Kivilaakso E: Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence of mucosul alkaline secretion. Gastroenterology 84:787-794, 1983
5. 5. Ross IN, Bahari HMM, Turnberg LA: The pH gradient adherent to rat fundic mucosa in vivo and the effects of potential damaging agents. Gastroenterology 81:713-718, 1981
6. 6. Bahari HMM, Ross IN, Turnberg LA: Demonstration of a pH gradient across the mucus layer on the surface of human gastric mucosa in vitro. Gut 23:513-516, 1982
7. 7. Talley NJ, Ormand JE, Frie CA, Zinmeister AR: Stability of pH gradients in vivo across the stomach in Helicobacter pylori gastritis, dyspepsia and health. Am J Gastroenterol 87:590-594, 1992
8. 8. Kelly SM, Crampton JR, Hunter JO: Helicobacter pylori increases antral juxtamucosal pH. Dig Dis Sci 38:129-131, 1993
9. 9. Quigley EMM, Turnberg LA: The pH of the microclimate lining gastric and duodenal mucosa in vivo: Studies in control subjects and in duodenal ulcer patients. Gastroenterology 92:1876-1884, 1987
10. 10. Quigley EMM, Turnberg LA: Studies of luminal and mucosul pH in reflux esophagitis and antral gastritis. Dig Dis 10:134-143, 1992
11. 11. Shorrock CJ, Rees WDW: Overview of gastroduodenal mucosal protection. Am J Med 84(suppl):25-34, 1988
12. 2. J Clin Invest 72:295-303, 1983
13. 13. Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761-767, 1979
14. 2. Aliment Pharmacol Ther 5:127-133, 1991
15. 15. Hall DRW: Review of the modes of action of colloidal bismuth subcitrate. Scand J Gastroenterol Suppl 157: 3-6, 1989
16. 16. Gorbach SL: Bismuth therapy in gastrointestinal disease. Gastroenterology 99:63-875, 1990
17. 17. Bierer DWS: Bismuth subsalicylate: history, chemistry and safety. Rev Infect Dis 12(suppl):S3-S8, 1990
18. 18. Marshall BJ: The use of bismuth in gastroenterology. The ACG committee on FDA-related matters. American College of Gastroenterology. Am J Gastroenterol 86:16-25, 1991
19. 19. Skoglund ML, Watters K: Bismuth concentrations at site of Campylobacter pylori colonization. Gastroenterology 94:A430, 1988
20. 20. Chu S, Tanaka S, Kaunitz JD, Montrose MH: Correlation of surface pH versus mucus gel thickness by in vivo confocal microscopy of rat mucosa. Gastroenterology 114:A92, 1998
21. 21. Tarnawski A, Hollander D, Stachura J, Klimcyzk B, Mach T, Bogdal J: Alcohol injury to the normal human gastric mucosa: Endoscopic, histologic and functional assessment. Clin Invest Med 10(3):259-263, 1987
22. 22. Tarnawski A, Glick M, Stachura J, Hollander D, Gergely H: Efficacy of sulcralfate and cimetidine in protection of the human gastric mucosa against alcohol injury. Am J Med 83(suppl):31-37, 1987