Long-chain fatty acid transport in bacteria and yeast. Paradigms for defining the mechanism underlying this protein-mediated process

Molecular and Cellular Biochemistry

Volumn 192, Issue 1-2, 1999, Pages 41-52

  DiRusso, Concetta C ^a   Black, Paul N ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Fatty acid transport; Fatty acyl CoA synthetase; Long chain fatty acids

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; FATTY ACID BINDING PROTEIN; LONG CHAIN FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; PROTON; THIOESTER;

BACTERIUM; CONFERENCE PAPER; ELECTROCHEMISTRY; ESCHERICHIA COLI; FATTY ACID TRANSPORT; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN LIPID INTERACTION; SACCHAROMYCES CEREVISIAE; YEAST;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 0032911908     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-4929-1_5     Document Type: Conference Paper

References (86)

1. Carmen GM, Zeimetz GM: Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae. J Biol Chem 271: 13293-13296, 1996
2. Greenberg ML, Lopes JM: Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae. Microbiol Rev 60: 1-20, 1996
3. Hillgartner FB, Salati LM, Goodridge AG: Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol Rev 25: 47-76, 1995
4. Paltauf BL, Kohlwein SD, Henry SA: Regulation and compartmentalization of lipid synthesis in yeast. In: E.W. Jones, J.R. Pringle, J.R. Broach (eds). The Molecular and Cellular Biology of the Yeast Saccharomyces cerevisiae: Gene Expression. Cold Spring Harbor Press, Cold Spring Harbor, NY, 1992, pp 415-500
5. Glick BS, Rothman JE: Possible role for fatty acyl-coenzyme A in intracellular protein transport. Nature 326: 309-312, 1987
6. Pfanner N, Orci L, Glick BS, Amherdt M, Ardern SR, Malhotra V, Rothman JE: Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cistemae. Cell 59: 95-102, 1989
7. Gordon JI, Duronio RS, Rudnick DA, Adams SP, Gokel GW: Protein N-myristoylation. J Biol Chem 266: 8647-8650, 1991
8. McLaughlin S, Aderem A: The myristoyl-electrostatic switch: A modulator of reversible protein-membrane interactions. TIBS 20: 270-276, 1995
9. Schneiter R, Kohlwein SD: Organelle structure, function and inheritance in yeast: A role for fatty acid synthesis? Cell 88: 431-434, 1997
10. Fujimoto Y, Tsunomori M, Sumiya T, Nishida H, Sakuma S, Fujita T: Effects of fatty acyl coenzyme A esters on lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. Prostaglandins Leuko Essen Fatty Acids 52: 255-258, 1995
11. Fulceri R, Gamberucci A, Scott HM, Giunti R, Burchell A, Benedetti A: Fatty acyl-CoA esters inhibit glucose-6-phosphatase in rat liver microsomes. Biochem J 307: 391-397, 1995
12. Lai JCK, Liang BB, Jarri EL, Cooper AJL, Lu DR: Differential effects of fatty acyl coenzyme A derivatives on citrate synthase and glutamate dehydrogenase. Res Com Chem Pathol Pharm 82: 331-338, 1993
13. Yamashita A, Watanabe M, Tonegawa T, Sugiura T, Waku K: Acyl-CoA binding and acylation of UDP-glucuronosyltransferase isoforms of rat liver: Their effect on enzyme activity. Biochem J 312: 301-308, 1995
14. Aihaud GR, Abumrad NA, Amri E-Z, Grimaldi PA: A new look at fatty acids as signal-transducing molecules. In: G.C. Simopoulos, E. Tremoli (eds). Fatty Acids and Lipids: Biological Aspects. Karger Press, Basel, Switzerland, 1994
15. Glatz JE, Borchers T, Spener E, van der Vusse, GJ: Fatty acids in cell signaling: Modulation by lipid binding proteins. Prostaglandins Leuko Essen Fatty Acids 52: 121-127, 1995
16. Korchak HM, Kane LH, Rossi MW, Corkey BE: Long-chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophils. J Biol Chem 269: 30281-30287, 1994
17. Shrago E, Woldegiorgis G, Ruoho AE, DiRusso CC: Fatty acyl CoA esters as regulators of cell metabolism. Prostaglandins Leuko Essen Fatty Acids 52: 163-166, 1995
18. 2+ permeability of endoplasmic-reticulum membranes from rat liver. Biochem J 306: 703-708, 1995
19. DiRusso CC: The role of long-chain acyl-CoA esters in the regulation of gene expression and metabolism. In: J.Y. Vanderhoek (ed). Escherichia coli. Frontiers in Bioactive Lipids. Plenum Press, NY, 1995, pp 15-22
20. DiRusso CC, Heimert TL, Metzger AK: Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. J Biol Chem 267: 8685-8691, 1992
21. DiRusso CC, Metzger AK, Heimert TL: Regulation of transcription of genes required for fatty acid transport and unsaturated fatty acid biosynthesis in Escherichia coli by FadR. Mol Microbiol 7: 311-322, 1993
22. Raman N, DiRusso CC: Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues required for ligand binding. J Biol Chem 270: 1092-1097, 1995
23. DiRusso CC, Nystom T: The fats of Escherichia coli during infancy and old age. Mol Microbiol 27: 1-8, 1998
24. Abumrad NA, Forest CC, Regen DM, Sanders S: Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation. Proc Nat Acad Sci USA 88: 6008-6012, 1991
25. Abumrad NA, El-Maghrabi MR, Amri E-Z, Lopez E, Crimaldi PA: Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. J Biol Chem 268: 17665-17668, 1993
26. Harmon CM, Abumrad NA: Binding of sulfosuccinimidyl fatty acid to adipocyte membrane proteins: Isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acid. J Membr Biol 133: 43-49, 1993
27. Schaffer JE, Lodish HF: Expression cloning and characterization of a novel adipocyte long-chain fatty acid transport protein. Cell 79: 427-436, 1994
28. Schaffer JE, Lodish HF: Molecular mechanism of long-chain fatty acid uptake. Trends Cardiovasc Med 5: 218-224, 1995
29. Berk PD, Wada H, Horio Y, Potter BL, Sorrentino D, Zhou SL, Isola LM, Stump D, Kiang CL, Thung S: Plasma membrane fatty acid binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related. Proc Nat Acad Sci USA 87: 3484-3488, 1990
30. Zhou S-L, Stump D, Isola LM, Berk PD: Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes. Biochem J 297: 315-319, 1994
31. Zhou S-L, Stump D, Kiang C-L, Isola LM, Berk PD: Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adipocytes mediates saturable fatty acid uptake. Proc Soc Exp Biol Med 208: 263-270, 1995
32. Black PN: Primary sequence of the Escherichia coli fadL gene encoding an outer membrane protein involved in fatty acid transport. J Bacteriol 173: 535-442, 1991
33. Black PN: Characterization of FadL-specific fatty acid binding in Escherichia coli. Biochim Biophys Acta 1046: 97-105, 1990
34. Black PN, DiRusso CC: Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli. Biochim Biophys Acta 1210: 123-145, 1994
35. Black PN, DiRusso CC, Metzger AK, Heimert TL: Cloning, sequencing, and characterization of the fadD gene of Escherichia coli encoding fatty acyl coenzyme A synthetase. J Biol Chem 267: 25513-25520, 1992
36. Black PN: Acyl-CoA synthetase and the transport of long-chain fatty acids. In: J.Y. Vanderhoek (ed). Frontiers in Bioactive Lipids. Plenum Press, NY, 1996, pp 7-14
37. Black PN, Zhang Q, Weimar JD, DiRusso CC: Mutational analysis of a fatty acyl-coenzyme A synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. J Biol Chem 272: 4896-4903, 1997
38. Kumar GB, Black PN: Linker mutagenesis of a bacterial fatty acid transport protein. Identification of domains with functional importance. J Biol Chem 266: 1348-1353, 1991
39. Kumar GB, Black PN: Bacterial long-chain fatty acid transport: Identification of amino acid residues within the outer membrane protein FadL required for activity. J Biol Chem 268: 15469-15476, 1993
40. 110 of protein FadL in the outer membrane of Echerichia coli is involved in the binding and uptake of long-chain fatty acids. Possible role of this residue in carboxylate binding. Biochem J 310: 389-394, 1995
41. Færgeman NL, DiRusso CC, Elberger A, Knudsen L, Black PN: Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids. J Biol Chem 272: 8531-8538, 1997
42. Overath P, Pauli G, Schairer HU: Fatty acid degradation in Escherichia coli. An inducible acyl-CoA synthetase, the mapping of old mutants, and isolation of regulatory mutants. Eur J Biochem 7: 559-574, 1969
43. Azizan A, Black PN: Use of transposon ThphoA to identify genes for cell envelope proteins of Escherichia coli required for long-chain fatty acid transport: The periplasmic protein Tsp potentiates long-chain fatty acid transport. J Bacteriol 176: 6653-6662, 1994
44. Kameda K: Partial purification and characterization of fatty acid binding protein(s) in Escherichia coli membranes and reconstitution of fatty acid transport system. Biochem Int 13: 343-350, 1986
45. + entry in pheroplasts of Echerichia coli K-12. Biochem Int 14: 227-234, 1987
46. Nunn WD, Simons RW: Transport of long-chain fatty acids by Escherichia coli: Mapping and characterization of mutants in the fadL gene. Proc Nat Acad Sci USA 75: 3377-3381, 1978
47. Nunn WD, Simons RW, Egan PA, Maloy SR: Kinetics of the utilization of medium and long chain fatty acids by a mutant of Escherichia coli defective in fadL gene. J Biol Chem 254: 9130-9134, 1979
48. Maloy SR, Ginsburgh CL, Simons RW, Nunn WD: Transport of long and medium chain fatty acids by Escherichia coli K12. J Biol Chem 256: 3735-3742, 1981
49. Black PN: The fadL gene product of Escherichia coli is an outer membrane protein required for uptake of long-chain fatty acids and involved in sensitivity to bacteriophage T2. J Bacteriol 170: 2850-2854, 1988
50. Azizan A, Sherin D, DiRusso CC, Black PN: Energetics underlying the process of long-chain fatty acid transport: The roles of ATP synthase and an energized membrane (submitted)
51. Mangroo D, Gerber GE: Fatty acid uptake in Escherichia coli: Regulation by recruitment of fatty acyl CoA synthetase to the plasma membrane. Biochem Cell Biol 71: 431-443, 1993
52. Berger EA: Different mechanisms of energy coupling for the active transport of proline and glutamine in Escherichia coli. Proc Nat Acad Sci USA 70: 1514-1518, 1973
53. Berger EA, Heppel LA: Different mechanisms of energy coupling for the shock-sensitive and shock-resistant amino acid permeases of Escherichia coli. J Biol Chem 249: 7747-7755, 1974
54. Kohlwein SD, Paltauf F: Uptake of fatty acids by the yeasts Saccharomyces uvarum and Saccharomycopsis lipolytica. Biochim Biophys Acta 792: 310-317, 1983
55. Knoll LL, Johnson DR, Gordon JI: Complementation of Saccharomyces cerevisiae strains containing fatty acid activation gene (FAA) deletions with a mammalian acyl CoA synthetase. J Biol Chem 270: 10861-10867, 1995
56. Johnson DR, Knoll LL, Levin DE, Gordon JI: Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: As assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism. J Cell Biol 127: 751-762, 1994
57. Knoll LJ, Johnson DR, Gordon JI: Biochemical studies of three Saccharomyces cerevisiae acyl-CoA synthetases, Faa1p, Faa2p, and Faa3p. J Biol Chem 269: 16348-16356, 1994
58. Rasmusen JT, Færgeman NL, Kristiansen K, Knudsen J: Acyl-CoA binding protein (ACBP) can mediate intermembrane transport and donate acyl-CoA for beta-oxidation and glycerolipid synthesis. Biochem J 299: 165-170, 1994
59. Andreasen AA, Stier TJB: Anaerobic nutrition of Saccharomyces cerevisiae. II. Unsaturated fatty acid requirement for growth in a defined medium. J Cell Comp Physiol 41: 23-26, 1953
60. Bourot S, Karst F: Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Gene 165: 97-102, 1995
61. Sallus L, Haselbeck RL, Nunn WD: Regulation of fatty acid transport in Escherichia coli: Analysis by operon fusion. J Bacteriol 155: 1450-1454, 1983
62. Higashitani HA, Nishimura Y, Hara H, Aiba H, Mizuno T, Horiuchi K: Osmoregulation of the fatty acid receptor gene fadL in Escherichia coli. Mol Gen Genet 240: 339-347, 1993
63. Mahan ML, Tobias JW, Slauch JM, Hanna PC, Collier RL, Mekalanos JJ: Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. Proc Nat Acad Sci USA 92: 669-673, 1995
64. Pace L, Hayman ML, Galan JE: Signal transduction and invasion of epithelial cells by S. typhimurium. Cell 72: 505-514, 1993
65. Paltauf BL, Kohlwein SD, Henry SA: Regulation and compartmentalization of lipid synthesis in yeast. In: E.W. Jones, J.R. Pringle, J.R. Broach (eds). The Molecular and Cellular Biology of the Yeast Saccharomyces cerevisiae: Gene expression. Cold Spring Harbor Press, Cold Spring Harbor, NY, 1992, pp 415-500
66. Elgersma Y, Tabak HF: Proteins involved in peroxisome biogenesis and functioning. Biochim Biophys Acta 1286: 269-283, 1996
67. Hiltunen JK, Wenzel B, Beyer A, Erdman R, Fossa A, Kunau W: Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. J Biol Chem 267: 6646-6653, 1992
68. Karlskov Schjerling C, Hummel R, Hansen JK, Børsting C, Mikkelsen JM, Kristiansen K, Knudsen J: Disruption of the gene encoding the acyl CoA binding protein (ACBI) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 37: 22514-22521, 1996
69. Rasmusen JT, Rosendal J, Knudsen J: Interaction of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product, or inhibitor. Biochem J 292: 907-913, 1993
70. Hettema EH, van Roermund CWT, Distel B, van den Berg M, Vilela C, Rodrigues-Pousada C, Wanders RJA, Tabak HF: The ABC transporter proteins Pat 1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J 15: 3813-3822, 1996
71. Lombard-Platet G, Savary S, Sarde CO, Mandel JL, Chimini G: A close relative of the adrenoleukodystrophy (ADL) gene codes for a peroxisomal protein with a specific expression pattern. Proc Nat Acad Sci USA 93: 1265-1269, 1996
72. Shani N, Valle D: A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Nat Acad Sci USA 93: 11901-11906, 1996
73. Blobel F, Erdman R: Identification of a yeast peroxisomal member of AMP binding proteins. Eur J Biochem 240: 468-476, 1996
74. Frayn KN, Shadid S, Hamlani R, Humphreys SM, Clark ML, Fielding BA, Boland O, Coppack SW: Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. Am J Physiol 266: E308-E317, 1994
75. Gonzalez CI, Martin CE: Fatty Acid-responsive control of mRNA stability. J Biol Chem 271: 25801-25809, 1996
76. Jump DB, Clarke SD, Thelen A, Liimatta M: Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 35: 1076-1084, 1994
77. Cornelius P, MacDougal OA, Lane MD: Regulation of adipocyte development. Annu Rev Nutr 14: 99-129, 1994
78. Grimaldi PA, Gaillard D, Inadera H, Teboul L, Ailhaud G, Amri E-Z: Molecular mechanisms involved in the adipogenic action of fatty acids. In: J.Y. Vanderhoek (ed). Frontiers in Bioactive Lipids. 1996, pp 1-6
79. Einerhand AW, Kos W, Distel D, Tabak HF: Characterization of a transcriptional control element involved in the proliferation of peroxisomes in yeast in response to oleate. Eur J Biochem 214: 323-331, 1993
80. Burczynski FL, Cai ZS, Moran JB, Geisbuhler T, Rovetto M: Palmitate uptake by cardiac myocytes and endothelial cells. Am J Physiol 268: H1659-H1666, 1995
81. Lopaschuk GD, Collins-Nakai RL, Itoi T: Developmental changes in energy substrate use by the heart. Cardio Res 26: 1172-1180, 1992
82. Schulz H: Regulation of fatty acid oxidation in the heart. J Nutr 124: 165-171, 1994
83. Van Nieuwenhoven FA, Verstijnen CP, Abumrad NA, Willemsen PF, Van Eys GL, Van der Vusse GL, Glatz JF: Putative fatty acid translocase and cytoplasmic fatty acid binding protein am co-expressed in rat heart and skeletal muscles. Biochem Biophys Res Comm 207: 747-752, 1995
84. Vork MM, Glatz JFC, van der Vusse: On the mechanism of long chain fatty acid transport in cardiomyocytes as facilitated by cytoplasmic fatty acid binding protein. J Theor Biol 160: 207-222, 1993
85. Franken PR, De Geeter E, Dendale P, Block P, Bossuyt A: Abnormal free fatty acid uptake in subacute myocardial infarction after coronary thrombolysis: Correlation with wall motion and inotropic reserve. J Nucl Med 35: 1758-1765, 1994
86. Siguel EN, Lerman RH: Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. Metab Clin Exp 43: 982-993, 1994