The pulmonary first-pass uptake of five nondepolarizing muscle relaxants in the pig

Anesthesiology

Volumn 90, Issue 2, 1999, Pages 477-483

  Beaufort, Ton M ^a,b   Proost, Johannes H ^a   Houwertjes, Martin C ^a   Roggeveld, Jan ^a   Wierda, J Mark K H ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Onset time; Pharmacokinetics; Plasma concentration; Potency

Indexed keywords

1 (3ALPHA ACETOXY 17BETA BUTYRYLOXY 2BETA PIPERIDINO 5ALPHA ANDROSTAN 16BETA YL) 1 ALLYLPIPERIDINIUM BROMIDE; NEUROMUSCULAR BLOCKING AGENT; RAPACURONIUM BROMIDE; ROCURONIUM; TUBOCURARINE CHLORIDE; VECURONIUM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG POTENCY; DRUG UPTAKE; FIRST PASS EFFECT; INTRAARTERIAL DRUG ADMINISTRATION; LUNG CLEARANCE; NEUROMUSCULAR BLOCKING; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANDROSTANOLS; ANIMALS; LUNG; NEUROMUSCULAR NONDEPOLARIZING AGENTS; SWINE; TUBOCURARINE; VECURONIUM BROMIDE;

EID: 0032911579     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199902000-00023     Document Type: Article

References (23)

1. Cohen EN, Hood N, Golling R: Use of whole-body autoradiography for determination of uptake and distribution of labeled muscle relaxants in the rat. ANESTHESIOLOGY 1968; 29:987-93
2. Gehr P. Bachofen M, Weibel ER: The normal human lung: Ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol 1978; 32:121-40
3. Jorfeldt L, Lewis DH, Löfström JB, Post C: Lung uptake of lidocaine in healthy volunteers. Acta Anaesthesiol Scand 1979; 23:567-74
4. Roerig DL, Kotrly KJ, Dawson CA, AhIf SB, Gualtieri JF. Kampine JP: First-pass uptake of verapamil. diazepam, and thiopental in the human lung. Anesth Analg 1989; 69:461-6
5. Camus P, Coudert B, D'Athis P. Dumas M, Escousse A, Jeannin L: Pharmacokinetics of amiodarone in the isolated rat lung. J Pharmacol Exp Ther 1990; 254:336-43
6. Cardoso PFG, Spino M, Mayer E, Shi SQ, Pop RD, Puskas J, Perrier D, Tong J, Baines AD, Patterson GA: Use of an isolated in situ canine lung perfusion model to evaluate dopamine clearance by the lung. J Pharmacol Exp Ther 1991; 259:1271-6
7. Sumikawa K, Hayashi Y, Yamatodani A, Yoshiya I: Contribution of the lungs to the clearance of exogenous dopamine in humans. Anesth Analg 1991; 72:622-6
8. Hess R, Herz A, Friedel K: Pharmacokinetics of fentanyl in rabbits in view of the importance for limiting the effect. J Pharmacol Exp Ther 1971; 179:474-84
9. Lehmann KA, Hunger L, Brandt K, Daub D: Biotransformation von fentanyl. Anaesthesist 1983; 32:165-73
10. Taeger K, Weninger E, Schmelzer F, Adt M, Franke N, Peter K: Pulmonary kinetics of fentanyl and alfentanil in surgical patients. Br J Anaesth 1988; 61:425-34
11. Roerig DL, Kotrly KJ, Vucins EJ, Ahlf SB, Dawson CA, Kampine JP: First-pass uptake of fentanyl, meperidine, and morphine in the human lung: ANESTHESIOLOGY 1987; 67:466-72
12. Boer F, Bovill JG, Burm AGL, Mooren RAG: Uptake of sufentanil, alfentanil and morphine in the lungs of patients about to undergo cornary artery surgery. Br J Anaesthesia 1992; 68:370-5
13. Matot I, Neely CF, Katz RY, Neufeld GR: Pulmonary uptake of propofol in cats: Effect of fentanyl and halothane. ANESTHESIOLOGY 1993; 78:1157-65
14. Matot I, Neely CF, Katz RY, Marshall BE: Fentanyl and propofol uptake by the lung: Effect of time between injections. Acta Anaesthesiol Scand 1994; 38:711-5
15. Kleef UW, Proost JH, Roggeveld J, Wierda JMKH: Determination of rocuronium and its putative metabolites in body fluids and tissue homogenates. J Chromatography 1993; 621:65-76
16. Nielsen NC: Spectrophotometric determination of indocyanin green in plasma especially with a view to an improved correction for blank density. Scand J Clin Lab Invest 1963; 15:613-21
17. Bertler A, Lewis DH, Löfström JB, Post C: In vivo lung uptake of lidocaine in pigs. Acta Anaesth Scand 1978; 22:530-6
18. 14 C-propranolol by the lung. Thorax 1979; 34:810-3
19. Guyton AC: Cardiac output, venous return, and their regulation. Textbook of Medical Physiology. 7th edition. Philadelphia, WB Saunders, 1986, pp 272-85
20. Proost JH, Roggeveld J, Wierda JMKH, Meijer DKF: Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates. J Pharmacol Exp Ther 1997: 282:715-26
21. Meuldermans WEG, Hurkmans RMA, Heykants JJP: Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood. Arch Im Pharmacodyn Ther 1982; 257:4-19
22. Roerig DL, Dahl RR, Dawson CA, Wang RIH: Effect of plasma protein binding on the uptake of methadone and diazepam in the isolated perfused rat lung. Drug Metab Dispos 1984; 12:536-42
23. Ott P, Keiding S, Bass L: Plasma elimination of indocyanine green in the intact pig after bolus injection and during constant infusion: Comparison of spectrophotometry and high-pressure liguid chromatography for concentration analysis. Hepatology 1993; 18:1504-15