Continuously infused intrathecal baclofen for spastic/dystonic hemiplegia: A preliminary report

American Journal of Physical Medicine and Rehabilitation

Volumn 78, Issue 3, 1999, Pages 247-254

  Meythaler, Jay M ^a   Guin Renfroe, Sharon ^a   Hadley, Mark N ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Baclofen; Brain Injury; Hemiparesis; Hypertonia; Intrathecal; Rehabilitation; Spasticity; Stroke

Indexed keywords

CONTROLLED DRUG DELIVERY; DRUG DOSAGE; DRUG INFUSION; STATISTICAL TESTS;

ASHWORTH RIGIDITY SCORES; WILCOXON'S SIGNED-RANK TESTS;

PATIENT REHABILITATION;

BACLOFEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG EFFECT; DYSTONIA; FEMALE; HEMIPLEGIA; HUMAN; INTRATHECAL DRUG ADMINISTRATION; MALE; MOTOR PERFORMANCE; MUSCLE STRENGTH; SPASTICITY; STROKE;

ADULT; AGED; BACLOFEN; BRAIN INJURIES; CEREBROVASCULAR DISORDERS; DOUBLE-BLIND METHOD; DYSTONIA; FEMALE; HEMIPLEGIA; HUMANS; INFUSION PUMPS, IMPLANTABLE; INFUSIONS, PARENTERAL; INJECTIONS, SPINAL; MALE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; MUSCLE SPASTICITY; SEVERITY OF ILLNESS INDEX;

EID: 0032911151     PISSN: 08949115     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002060-199905000-00012     Document Type: Article

References (26)

1. Meythaler JM, Steers WD, Tuel SM, Cross LL, Haworth CS: Continuous intrathecal baclofen in spinal cord spasticity: a prospective study. Am J Phys Med Rehabil 1992;71:321-327.
2. Meythaler JM, Steers WD, Tuel SM, Sesco DV, Haworth CS: Use of intrathecal baclofen in familial spastic paraparesis. Arch Phys Med Rehabil 1992;73:794-797.
3. Yarkony GM, Sahgal V: Contractures: a major complication of craniocerebral trauma. Clin Orthop Rel Res 87;219:93-96.
4. Young RR, Delwaide PJ: Drug therapy: spasticity (first of two parts). N Engl J Med 1981;304:28-33.
5. Young RR, Delwaide PJ: Drug therapy: spasticity (second of two parts). N Engl J Med 1981;304:96-99.
6. Ashby P, Verrier M, Lightfoot E: Segmental reflex pathways in spinal shock and spinal spasticity in man. J Neurol Neurosurg Psychiatry 1974;37:1352-1360.
7. Mann NH: Functional management of spasticity after head injury. J Neurol Rehabil 1991;5:51-54.
8. Meythaler JM, DeVivo MJ, Hadley MN: Prospective study on the use of bolus intrathecal baclofen for spastic hypertonia due to acquired brain injury. Arch Phys Med Rehabil 1996;77:461-466.
9. Meythaler JM, McCary A, Hadley MN: Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report. J Neurosurg 1997;87:415-419.
10. Penn RD, Savoy SM, Corcos DM, et al.: Intrathecal baclofen for severe spinal spasticity. N Engl J Med 1989;320:1517-1522.
11. Albright LA, Meythaler JM, Ivanhoe CB: Intrathecal Baclofen Therapy for Spasticity of Cerebral Origin: Patient Selection Guidelines. Minneapolis, Medtronics, Inc., 1997.
12. Lee KC, Carson L, Kinnin E, Patterson V: The Ashworth scale: a reliable and reproducible method of measuring spasticity. J Neural Rehabil 1989;3:205-209.
13. Adams RD, Victor M (eds): Principles of Neurology, ed 5. New York, McGraw-Hill, 1993, p 68.
14. Meythaler JM: Pharmacology update: intrathecal baclofen for spastic hypertonia in brain injury. J Head Trauma Rehabil 1997;12:87-90.
15. Albright LA, Barry MJ, Fasick P, Barron W, Schultz B: Continuous intrathecal baclofen for symptomatic generalized dystonia. Neurosurgery 1996;38:934-939.
16. Ford B, Green P, Louis ED, et al.: Use of intrathecal baclofen in the treatment of patients with dystonia. Arch Neurol 1996;53:1241-1246
17. Hattab JR: Review of European clinical trials with baclofen, in Feldman RG, Young RR, Kiella WP (eds): Spasticity: Disordered Motor Control. Chicago, Year Book, 1980, pp 71-75.
18. MacDonell RAL, Talolla A, Swash M, Grundy D: Intrathecal baclofen and the H-reflex. J Neurol Neurosurg Psychiatry 1989;52:1110-1112.
19. Terrence DV, Fromm GH: Complications of baclofen withdrawal. Arch Neurol 1981;38:588-589.
20. Wilson PR, Yaksh TL: Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur J Pharmacol 1978;51:323-330.
21. Yaksh TL: Ramana Reddy SV. Studies in the primate on the analgetic effects associated with intrathecal actions of opiate, L-adrenergic agonists and baclofen. Anesthesiology 1981;54:451-467.
22. Albright LA, Barron WB, Fasick MP, Polinko P, Janosky J: Continuous intrathecal baclofen infusion for spasticity of cerebral origin. J Am Med Assoc 1993;270:2475-2477.
23. Coffey RJ, Cahill D, Steers W, et al. The Intrathecal Baclofen Multicenter Study Group: intrathecal baclofen for intractable spasticity of spinal origin - results of a long-term multicenter study. J Neurosurg 1993;78:226-232.
24. Lazorthes Y, Sallerin-Caute B, Verdie J, Bastide R, Carillo J: Chronic intrathecal baclofen administration for control of severe spasticity. J Neurosurg 1990;72:393-402.
25. Muller H, Zierski J, Dralle D, Krauss D, Mutschler E: Pharmacokinetics of intrathecal baclofen, in Muller H, Zierski J, Penn RD (eds): Local-Spinal Therapy of Spasticity. Berlin, Springer-Verlag, 1988, pp 223-226.
26. Meythaler JM, McCary A, Hadley MN: Intrathecal baclofen for spastic hypertonia in adult brain injury. Perspect Neurosurg 1996;7:99-107.