Immunological defect in leprosy patients: Altered T-lymphocyte signals

FEMS Immunology and Medical Microbiology

Volumn 23, Issue 4, 1999, Pages 355-362

  Sharma, Nidhi ^a   Sharma, V K ^a   Gupta, Anu ^a   Kaur, Inderjeet ^a   Ganguly, N K ^b  

^a Venereol Leprology Postgrad I ^*

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Inositol triphosphate; Intracellular calcium; Leprosy; Protein kinase C; T lymphocyte

Indexed keywords

BACTERIAL ANTIGEN; CALCIMYCIN; CALCIUM; INOSITOL TRISPHOSPHATE; MITOGENIC AGENT; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ARTICLE; CALCIUM CELL LEVEL; CLINICAL ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LEPROSY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

CALCIUM; CELL DIVISION; HUMANS; INOSITOL PHOSPHATES; INTRACELLULAR FLUID; LEPROSY; PROTEIN KINASE C; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0032911126     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(98)00155-2     Document Type: Article

References (32)

1. Nelson, D.S., Penrose, J.M., Waters, J.M.F., Pearson, J.M.H. and Nelson, M. (1975) Depressive effect of serum from patients with leprosy in mixed lymphocyte reactions. Clin. Exp. Immunol. 22, 385-390.
2. Nath, I., Curtis, J., Sharma, A.K. and Talwar, G.P. (1977) Circulating T cell numbers and their mitogenic potential in leprosy correlation with bacterial blood. Clin. Exp. Immunol. 29, 393-400.
3. Choudhuri, K. (1995) The immunology of leprosy: unravelling an enigma. Int. J. Lepr. Other Myco. Dis. 63, 430-447.
4. Imboden, J., Weiss, A. and Stobo, J. (1985) The antigen receptor of a human T cell line initiates activation by increasing cytosolic free calcium. J. Immunol. 134, 663-669.
5. Manger, B., Weiss, A., Imboden, J., Laing, T. and Stobo, J. (1987) The role of PKC in transmembrane signalling by the T cell antigen receptor complex. J. Immunol. 139, 2755-2760.
6. Nishizuka, Y. (1992) Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
7. Geller, R.L., Gromo, G., Inversardi, L., Ferrero, E. and Bach, F.H. (1987) Stepwise activation of T cells role of the calcium ionophore A23187. J. Immunol. 139, 3930-3938.
8. Babbitt, B.P., Allen, P.M., Matsuedo, G., Haber, E. and Unanue, E.R. (1985) Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317, 359-361.
9. Mueller, D.L., Jenkins, M.K. and Shwartz, R.H. (1989) Clonal expansion versus functional clonal inactivation, a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445-451.
10. Nossal, G.J.V. (1994) Negative selection of lymphocytes. Cell 76, 229-239.
11. Nossal, G.J.V. and Pike, B.L. (1980) Clonal anergy: persistence in tolerant mice of antigen binding B lymphocytes incapable of responding to antigen or mitogen. Proc. Natl. Acad. Sci. USA 77, 1602-1606.
12. Kang, S.M., Beverly, B., Tran, A.C., Brorson, K., Schwartz, R.H. and Lenardo, M.J. (1992) Translocation by AP-1 is a molecular target of T cell clonal anergy. Science 257, 1134-1138.
13. Ridley, D.S. and Jopling, W.J. (1966) Classification of leprosy according to immunity: a five group system. Int. J. Lepr. 34, 255-273.
14. Boyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21 (S97), 77-89.
15. Julius, M.H., Simpson, E. and Herzenberg, L.A. (1973) A rapid method for isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol. 3, 645-651.
16. Hudson, L. and Hay, F.C. (1989) The Basic Techniques in Practical Immunology, 3rd edn., pp. 1-32. Blackwell Scientific Publications, Oxford.
17. Oldham, K.G. (1990) Polyphosphoinositide Turnover. Receptor Effector Coupling. A Practical Approach (Hulme, E.C., Ed.), pp. 99-102. Oxford University Press, Oxford.
18. McCarthy, S.A., Hallam, T.J. and Merritt, J.E. (1989) Activation of protein kinase C in human neutrophils attenuates agonists stimulated rise in cytosolic free calcium concentration by inhibiting divalent cation influx and intracellular calcium release in addition to stimulating calcium efflux. Biochem. J. 4264, 357-374.
19. Yamiuchi, Y., Nagasawa, K., Mayumi, T., Horiuchit, T. and Niho, Y. (1989) Activation of protein kinase C induces differentiation in human T lymphoblastic cell lines Molt-3. Br. J. Cancer 60, 15-19.
20. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1957) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
21. Sehgal, V.N. (1987) Clinical Leprosy, 2nd edn., pp. 88-93. Jaypee Bros., New Delhi, India.
22. Cohn, Z.A. and Kaplan, G. (1986) Human leprosy, defects in cell mediated immunity. In: Mechanism of Host Resistance to Infectious Agents, Tumors and Allografts (Steinman, R.M. and North, R.J., Eds.), pp. 285-304. Rockefeller University Press, New York.
23. Kaplan, G. and Cohn, Z. (1986) The Immunobiology of Leprosy. Int. Rev. Exp. Pathol. 28, 45-78.
24. Imboden, J.B. and Stobo, J.D. (1985) Transmembrane signalling by the T cell: antigen receptor: perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J. Exp. Med. 161, 446-456.
25. Tsien, R.W. and Tsien, R.Y. (1993) Calcium channels, stores and oscillations. Annu. Rev. Cell. Biol. 6, 715-760.
26. Lorado, J., LeDeist, F., Griscelli, C. and Fisher, A. (1990) Inositol 1,4,5-triphosphate and arachidonic acid induced calcium mobilization in T and B cells. Cell. Immunol. 126, 245-254.
27. Berridge, M.J. (1993) Inositol triphosphate and calcium signalling. Nature 361, 315-325.
28. Abbas, A.K., Lichiman, A.H. and Pober, J.S. (1991) Molecular basis of T cell antigen recognition and activation. In: Cellular and Molecular Immunology (Wonsiewiez, M.J., Ed.), pp. 139-166. W.B. Saunders.
29. Nisbet-Brown, E.R., Cheung, J.L. and Gelfand, E. (1985) Antigen dependent increase in cytosolic free calcium in specific human T lymphocyte clones. Nature 316, 545-547.
30. O'Flynn, K., Zanders, E.D., Lamb, J.R., Beverly, P.C.L., Wallace, D.L., Tatham, P.C.R., Tax, W.J.M. and Linch, D.C. (1985) Investigations of early T cell activation analysis of the effect of specific antigen IL-2 and monoclonal antibody on intracellular free calcium concentration. Eur. J. Immunol. 15, 7-14.
31. Gajewski, T.F., Qian, D., Fields, P. and Fitch, F.W. (1994) Anergic T lymphocyte clones have altered inositol phosphate, calcium and tyrosine kinase signalling pathways. Proc. Natl. Acad. Sci. USA 91, 38-42.
32. Lancaster, J.S., Steinberg, T.H. and Allen, P.M. (1997) Selective loss of calcium ion signalling pathway in T cells maturing towards a T helper 2 phenotype. J. Immunol. 159, 1160-1168.