Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos)

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 122, Issue 2, 1999, Pages 273-281

  Renauld, Amy E ^b   Melancon, Mark J ^a   Sordillo, Lorraine M ^b  

^a PATUXENT WILDLIFE RESEARCH CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Naphthoflavone; 2 Methylbenzimidazole; Cytochrome P450; Dealkylase; Mallard duck; Microsomes; Monooxygenase; Proadifen

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; ALPHA NAPHTHOFLAVONE; BENZIMIDAZOLE DERIVATIVE; BETA NAPHTHOFLAVONE; CYTOCHROME P450; PENTOXYRESORUFIN DEALKYLASE; PHENOBARBITAL; PROADIFEN; RESORUFIN DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUCK; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BENZIMIDAZOLES; BENZOFLAVONES; BETA-NAPHTHOFLAVONE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DUCKS; ENZYME INDUCTION; MICROSOMES, LIVER; OXAZINES; OXIDOREDUCTASES; PHENOBARBITAL; POLYCHLORINATED BIPHENYLS; PROADIFEN;

EID: 0032910184     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(98)10119-6     Document Type: Article

References (31)

1. Banton M.I., Winston G.W., Flory W. Liver microsomal alkoxyphenoxazone O-dealkylases of white leghorn chickens: response to mixed function oxidase inducers. Comp Biochem Physiol. 102C:1992;455-458.
2. Burke M.D., Mayer R.T. Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins). Chem-Biol Interact. 45:1983;243-258.
3. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., Mayer R.T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol. 34:1985;3337-3345.
4. Burns K. Microsomal mixed function oxidases in an estuarine fish, Fundulus heteroclitus, and their induction as a result of environmental contamination. Comp Biochem Physiol. 53B:1975;443-446.
5. Colby H.D., Marquess M.L., Johnson P.B., Pope M.R., Heaps P.R. Comparative effects of mixed function oxidase inhibitors on adrenal and hepatic xenobiotic metabolism in the guinea pig. Biochem Pharmacol. 29:1980;951-953.
6. Dickins M., Bridges J.W. The relationship between the binding of 2-n-alkylbenzimidazoles to rat hepatic microsomal cytochrome P-450 and the inhibition of monooxygenation. Biochem Pharmacol. 31:1982;1315-1320.
7. Elangbam C.S., Qualls C.W., Lochmiller R.L., Novak J. Development of the Cotton rat (Sigmodon hispidus) as a biomonitor of environmental contamination with emphasis on hepatic cytochrome P-450 induction and population characteristics. Bull Environ Contam Toxicol. 42:1989;482-488.
8. Fowles J.R., Fairbrother A., Trust K.A., Kerkvliet N.I. Effects of Aroclor 1254 on the thyroid gland, immune function, and hepatic cytochrome P450 activity in mallards. Environ Res. 75:1997;119-129.
9. Guengerich F.P., Dannan G.A., Wright S.T., Martin M.V., Kaminski L.S. Purification and characterization of liver microsomal cytochrome P450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or B-naphthoflavone. Biochemistry. 21:1982;6019-6030.
10. Hansen A.J., May B.K. Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two P450 mRNAs transcribed from different genes. DNA Cell Biol. 8:1989;179-191.
11. Hobbs A.A., Mattschoss L.A., May B.K., Williams K.E., Elliott W.H. The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450. J Biol Chem. 261:1986;9444-9449.
12. Husain M.M., Kumar A., Mukhtar H. Inhibition of tissue aryl hydrocarbon (benzo[a]pyrene) hydroxylase by 7,8-benzoflavone in birds. Xenobiotica. 12:1982;375-380.
13. Iscan M.Y., Buyukbingol E., Iscan M., Sahin F., Safak C. Effects of 2-arylbenzimidazoles on rat hepatic microsomal monooxygenase system. Comp Biochem Physiol. 92C:1989;109-115.
14. Lee H., Wang H.-W., Su H.-Y., Hao N.J. The structure-activity relationships of flavonoids as inhibitors of cytochrome P-450 enzymes in rat liver microsomes and the mutagenicity of 2-amino-3-methyl-imidazo[4,5-f]quinoline. Mutagenesis. 9:1994;101-106.
15. Leffin M., Riviere J.L. Effects of some inducers on hepatic and extrahepatic drug metabolism in the Mallard duck (Anas platyrhynchos). Comp Biochem Physiol. 102C:1992;471-476.
16. Little P.J., Ryan A.J. Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats. J Med Chem. 25:1982;622-626.
17. Little P.J., James M.O., Bend J.R., Ryan A.J. Imidazole derivatives as inhibitors of cytochrome P-450-dependent oxidation and activators of epoxide hydrolase in hepatic microsomes from a marine fish. Biochem Pharmacol. 30:1981;2876-2880.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
19. Lubet R.A., Syi J.-L., Nelson J.O., Nims R.W. Induction of hepatic cytochrome P-450 mediated alkoxyresorufin O-dealkylase activities in different species by prototype P-450 inducers. Chem-Biol Interact. 75:1990;325-339.
20. Lubet RA, Nims RW, Beebe LE, Fox SD, Issaq HJ, McBeek. Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor 1254 in feral rodents. Arch Environ Contam Toxicol 1992;22:339-344.
21. Maenpaa J., Syngelma T., Honkakoski P., Lang M.A., Pelkonen O. Comparative studies on coumarin and testosterone metabolism in mouse and human livers: differential inhibitions by the anti-P450Coh antibody and metyrapone. Biochem Pharmacol. 42:1991;1229-1235.
22. Melancon MJ. Development of cytochrome P450 in avian species as a biomarker for environmental contaminant exposure and effect: procedures and baseline values. In: Bengtson DA, Henshel DS, editors. Environmental Toxicology and Risk Assessment: Biomarkers and Risk Assessment, vol. 5. ASTM STP 1306. Philadelphia: American Society for Testing and Materials, 1996:95-108.
23. Payne J.F., Fancey L.L., Rahimtula A.D., Porter E.L. Review and perspective on the use of mixed-function oxygenase enzymes in biological monitoring. Comp Biochem Physiol. 86C:1987;233-245.
24. Peakall DB, Norstrom RJ, Rahimtula AD, Butler RD. Characterization of mixed-function oxidase systems of the Herring gull and its implications for bioeffects monitoring. Environ Toxicol Chem 1986;5:379-385.
25. Rattner B.A., Hoffman D.J., Marn C.M. Use of mixed-function oxygenases to monitor contaminant exposure in wildlife. Environ Toxicol Chem. 8:1989;1093-1102.
26. Rattner B.A., Melancon M.J., Custer T.W., Hothem R.L., King A., LeCaptain L.J., Spann J.W., Woodin B.R., Stegeman J.J. Biomonitoring environmental contamination with pipping black-crowned night heron embryos: induction of cytochrome P450. Environ Toxicol Chem. 12:1993;1719-1732.
27. Schwab G.E., Raucy J.L., Johnson E.F. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by α-naphthoflavone. Mol Pharmacol. 33:1988;493-499.
28. Sinclair P.R., Bement W.J., Bonkovsky H.L., Sinclair J.F. Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Biochem J. 222:1984;737-748.
29. Stegeman JJ, Brouwer M, Di Guilio RT, Forlin L, Fowler BA, Sanders BM, Van Veld PA. Enzyme and protein synthesis as indicators of contaminant exposure. In: Huggett RJ, Kimerle RA, Mehrle PM Jr, Bergman HL, editors. Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress. Chelsea: MI Lewis, 1992:235-335.
30. Tsyrlov I.B., Lyakhovich V.V. Use of inhibition by metyrapone in a 'system with mutual exhaustion' to estimate active sites of various arylhydrocarbon hydroxylases. Biochemistry. 44(1):1980;922-930.
31. Wilkinson C.F., Hetnarski K., Cantwell G.P., DiCarlo F.D. Structure-activity relationships in the effects of 1-alkylimidazoles on microsomal oxidation in vitro and in vivo. Biochem Pharmacol. 23:1974;2377-2386.