High-performance liquid chromatographic analysis of the anti-tumor agent SCH 66336 in cynomolgus monkey plasma and evaluation of its chiral inversion in animals

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 728, Issue 1, 1999, Pages 133-141

  Kim, Hong ^a   Likhari, Paul ^b   Lin, Chin Chung ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Bioassay Laboratory   (United States)

Author keywords

SCH 66336

Indexed keywords

ANTINEOPLASTIC AGENT; AZATADINE MALEATE; LONAFARNIB; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; ENANTIOMER; EXTRACTION; MALE; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MACACA FASCICULARIS; MALE; PIPERIDINES; PYRIDINES; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0032909994     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00070-5     Document Type: Article

References (16)

1. Zhang F.L., Casey P.J. Annu. Rev. Biochem. 65:1996;241.
2. Schafer W.R., Rine J. Annu. Rev. Genetics. 25:1992;209.
3. Glomset J.A., Farnsworth C.C. Annu. Rev. Cell. Biol. 10:1994;181.
4. Barbacid M. Annu. Rev. Biochem. 56:1987;779.
5. Casey P.J., Solski P.A., Der C.J., Buss J.E. Proc. Natl. Acad. Sci. USA. 86:1989;8323.
6. Hancock J.F., Magee A.I., Childs J.E., Marshall C.J. Cell. 57:1989;1167.
7. Joneson T., White M.A., Wigler M.H., Bar-Sagi D. Science. 271:1996;810.
8. Lowy D.R., Willumsen B.M. Annu. Rev. Biochem. 62:1993;851.
9. Bishop W.R., Bond R., Petrin J., Wang L., Patton R., Doll R., Njoroge G., Catino J., Schwartz J., Windson W., Syto R., Carr D., James L., Kirschmeier P. J. Biol. Chem. 270:1995;30611.
10. Rodenhuis S. Semin. Cancer Biol. 3:1992;241.
11. M. Liu, S. Lee, B. Yaremko, J. Chen, J. Dell, L. Nielsen, P. Lipari, E. Ferrari, M. Malkowski, M.S. Bryant, F.G. Njoroge, A.G. Taveras, R.J. Doll, P. Kirschmeier, A.A. Nomeir, J. Kelly, S. Remiszewski, A.K. Mallams, A. Alfonso, F.P. Hollinger, A.B. Cooper, Y.-T. Liu, D. Rane, V. Girijavallabhan, A.K. Ganguly, W.R. Bishop. Proc. Am. Assoc. for Cancer Res. 39 (1998)270. # 1843.
12. Jamali F., Mehvar R., Pasutto F.M. J. Pharm. Sci. 78:1989;695.
13. Gubitz G. Chromatographia. 30:1990;555.
14. Gilbaldi M., Perrier D. Pharmacokinetics. 2nd ed :1982;409-417 Marcel Dekker, New York.
15. James G.L., Goldstein J.L., Brown M.S., Rawson T.E., Somers T.C., McDowell R.S., Crowley C., Lucas B., Levinson A., Marsters J.C. Science. 260:1993;1937.
16. Garcia A.M., Rowell C., Ackermann K., Kowalczyk J.J., Lewis M.D. J. Biol. Chem. 268:1993;18415.