The protective effect of lipoxygenase inhibitor FLM 5011 on mitochondria ultrastructure of ischemic and reperfused cardiomyocytes

Experimental and Toxicologic Pathology

Volumn 51, Issue 3, 1999, Pages 245-253

  Fitzl, G ^b   Winkler, D ^c   Wassilev, G ^a   Welt, K ^c  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c NONE

Author keywords

Cardiomyocytes; FLM 5011, lipoxygenase inhibitor; Heart, myocytes; Ischemia, cardiomyocytes; Lipoxygenase inhibitor FLM 5011; Reperfusion, heart

Indexed keywords

FLM 5011; LIPOXYGENASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DOG; DRUG EFFECT; FEMALE; HEART MITOCHONDRION; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0032909518     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(99)80109-2     Document Type: Article

References (32)

1. ANDRES J, FLAMENG W, VAN BELLE H: Energetic state of the postischemic myocardium and its relation to contractile failure. J Physiol Pharmac 1994; 45(1): 91-103
2. ASHRAF M: Ultrastructural alterations in the mitochondrial membranes of ischemic myocardium as revealed by freeze-fracture technique J Mol Cell Cardiol 1978; 10: 535-543
3. BECKER, BF, MASSOUDY P, PERMANETTER B, et al.: Mögliche Bedeutung von Sauerstoffradikalen für den Reperfusionsschaden. Z Kardiol 1993; 82(5): 49-50
4. BLEIFELD W: Herz und Kreislauf: klinische Pathophysiologie Springer Verlag Berlin - Heidelberg - New York -London - Paris - Tokio: 1987; 50-53, 150-151
5. DARLAY-USMAR VM, STONE D, SMITH DR: Oxygen and reperfusion damage: an overview (Review) Free Radical Res Communications 1989; 7 (3-6): 247-254
6. DENOSO E, LIPSKI J: Current cardiovascular topics Vol IV. Acute myocardial infarction. Thieme-Verlag Stuttgart 1978; 37-75
7. EGEROVA IF, POPOV I and V: Morphometric analysis of the mitochondria of cardiomyocytes in normal states and in postischemic reperfusion. Builleten Eksperimentalnoi Biologii I Meditsiny, Jugoslavia 1988; 106(7): 115-118
8. FERRARI R, CECONI C, CURELLO S, et al.: Metabolic changes during post-ischaemic reperfusion. J Mol Cell Cardiol 1988; 20(2): 119-133
9. FERRARI R, CECONI C, CURELLO S, et al.: Occurrence of oxidative stress during myocardial reperfusion (Review). Mol Cell Biochem 1992; 111(1-2): 61-69
10. FERRARI R, CECONI C, CURELLO S, et al.: Myocardial damage during ischaemia and reperfusion. Eur Heart J 1993; 14(G): 25-30
11. FERRARI R: Metabolic disturbances during myocardial ischemia and reperfusion (Review). Am J Cardiol 1995; 76(6): 17B-24B
12. FEUVRAY D: Structural, functional and metabolic correlates in ischemic hearts: effects of substrates. Am J Physiol 1981; 240(3): H 3918
13. FITZL G, WINKLER D, WASSILEW G, et al.: The protective effect of Iloprost, a PGL2 - analogue, on ultrastructure of ischemic and reperfused myocardial myocytes. Exp Toxic Pathol 1999; 51: 81-88
14. FRANKE S: Ultrastrukturelle Betrachtung der Frühphase des experimentellen Herzinfarkts beim Hund unter Berücksichtigung verschiedener Abnahmeorte und Reperfusion. Dissertation 1988
15. FRITZSCH RS: Die Morphometrie in der experimentellen Cytologie. Nova Acta Leopoldina (1975) 41: 205-234
16. GARDNER TJ: Oxygen radicals and myocardial stunning. J Card Surg 1994; 9(3): 422-424
17. GREVE G, ROTEEVATN S, GRONG K, et al.: Cellular morphometric changes in cat hearts subjected to three hours of regional ischemia. Virchows Archiv A Pathol Anat 1988; 412: 205-213
18. GREVE G, ROTEEVAN S, STANGELAND L: Morphological changes across the border zone of cat hearts subjected to regional ischaemia. Virchows Archiv A Pathol Anat 1989; 415: 323-333
19. 2 alpha on function, energy metabolism and calcium uptake in ischaemic/reperfused hearts. Cardiovasc Res 1993; 27(3): 396-402
20. KLONER RA, GANOTE CE, WHALEN JR, et al.: Effect of a Transient Period of Ischemia on Myocardial Cells. J Clin Invest 1974; 54: 1496-1508
21. LUDATSCHER RM, HASHMONAI M, PELEG H: The irreversible ischaemic lesion of human myocardium. Acta anat 1984; 118: 91-95
22. MELLORS A, TAPPEL AL, SAWANT PL, et al.: Mitochondrial swelling and uncoupling of oxidative phosphorylation by lysosomes. Biochem Biophys Acta; 1967; 143: 209-309
23. NE'EMANN Z, PINSON A: Oxygen and extracellular fluid restriction in cultured heart cells: electron microscopy studies. Cardiovas Res 1990; 24: 555-559
24. RAMISCH T: Qualitativ-und quantitativ-morphologische Veränderungen der Mitochondrien von Herzmuskelzellen bei offenen Herzoperationen unter Myokardprojektion. Diplomarbeit 1985, Universität Leipzig
25. RAVINGEROVA T, TRIBULOVA N, DZURBA A, et al.: Protektivny ucinok 7-oxoprostacyklinu na pretazenie myokardu vapnikom v izolovanom srdi potkana. Bratisl Lek Listy, Slowakia 1992; 93(7): 339-345
26. RÖTH E, TÖRÖK B, POLLAK Z, et al.: Myocardinal protection by antioxydant during permanent and temporary coronary occlusion in dogs. Basic Res Cardiol 1987; 82(2): 335-345
27. ROSSKAMM H, REINDELL H: Herzkrankheiten: Pathophysiologie, Diagnostik, Therapie. Springer Verlag Berlin - Heidelberg - New York 1982; 891-901
28. SCHAPER J, KREISEL E, HOLZNER JH: Atlas der koronaren Herzerkrankungen. PVG Pharmazeutische Verlags-gesellschaft mbH, München, 1984
29. SCHEWE et al.: Mechanism of action, molecularbiology, and clinical applications. In: Prostaglandins, Leukotriens, Lipoxins and PAF. BAILEY JM (ed.) New York: Plenum Pr 1991 XI, p 461
30. SCHMIEDL A, SCHNABEL PH A, MALL G, et al.: The surface to volume ratio of mitochondria, a suitable parameter for evaluating mitochondria swelling. Virchows Archiv A Pathol Anat 1990; 416: 305-315
31. 2 hypoxia. Exp Toxic Pathol, in press
32. WHITMER JT, IDELL-WENGER JA, ROVETTO MJ: Control of fatty acid metabolism in ischemic and hypoxic hearts. J Biol Chem 1978; 253: 4305-4309