Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs

Journal of Applied Physiology

Volumn 86, Issue 4, 1999, Pages 1236-1246

  Chen, Ling ^a   Sica, Anthony L ^a   Scharf, Steven M ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Catecholamines; Hexamethonium; Hypoxemia; Sleep apnea; Sympathetic nerve activity; Vagotomy

Indexed keywords

CATECHOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; CARDIOVASCULAR RESPONSE; FEMALE; HEART OUTPUT; MEAN ARTERIAL PRESSURE; NERVE STIMULATION; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; SWINE; SYMPATHECTOMY; SYMPATHETIC INNERVATION; SYMPATHETIC TONE; VAGOTOMY;

EID: 0032907940     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.4.1236     Document Type: Article

References (45)

1. Abboud, F. M., and M. D. Thames. Interaction of cardiovascular reflexes in circulatory control. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 2, chapt. 19, p. 675-753.
2. Anand, A. Reflex stimulation of aortic chemoreceptors through the stellate ganglion during hypoxia and hypotension in cats. J. Physiol. (Lond.) 491: 853-858, 1996.
3. Blake, D. W., and P. I. Korner. Effects of ketamine and althesin anesthesia on baroreceptor-heart rate reflex and hemodynamics of intact and pontine rabbits. J. Auton. Nerv. Syst. 5: 291-301, 1982.
4. Bonsignore, M. R., O. Marrone, G. Insalaco, and G. Bonsignore. The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms. Eur. Respir. J. 7: 786-805, 1994.
5. Carlson, J., J. Hedner, M. Elam, H. Ejnell, J. Sellgren, and B. G. Wallin. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103: 1763-1768, 1993.
6. Chen, L., and S. M. Scharf. Hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs. J. Appl. Physiol. 83: 485-497, 1997.
7. Chen, L., and S. M. Scharf. Systemic and myocardial hemodynamics during periodic obstructive apneas in sedated pigs. J. Appl. Physiol. 84: 1289-1298, 1998.
8. Chen, L., A. L. Sica, H. Greenberg, and S. M. Scharf. Role of hypoxemia and hypercapnia in acute cardiovascular response to periodic apneas in sedated pigs. Respir. Physiol. 111: 257-269, 1998.
9. Cheung, C. Y. Direct adrenal medullary catecholamine response to hypoxia in fetal sheep. J. Neurochem. 52: 148-153, 1989.
10. Coy, T. V., J. E. Dimsdale, S. Ancoli-Israel, and J. Clausen. Sleep apnoea and sympathetic nervous system activity: a review. J. Sleep Res. 5: 42-50, 1996.
11. Dimsdale, J. E., T. Coy, S. Ancoli-Israel, P. Mills, J. Clausen, and M. G. Ziegler. Sympathetic nervous system alterations in sleep apnea: the relative importance of respiratory disturbance, hypoxia, and sleep quality. Chest 111: 639-642, 1997.
12. Dimsdale, J. E., T. Coy, M. G. Ziegler, S. Ancoli-Israel, and J. Clausen. The effect of sleep apnea on plasma and urinary catecholamines. Sleep 18: 377-381, 1995.
13. Edwards, N., I. Wilcox, A. Keogh, and C. E. Sullivan. Hemodynamic responses to obstructive apneas during sleep are attenuated in heart transplant recipients (Abstract). Am. J. Respir. Crit. Care Med. 155: A678, 1997.
14. Franchini, K. G., and E. M. Krieger. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J. Auton. Nerv. Syst. 42: 63-69, 1993.
15. Heistad, D. D., and F. M. Abboud. Dichinso W. Richards Lecture. Circulatory adjustments to hypoxia. Circulation 61: 463-470, 1980.
16. Huang, W., S. Lahiri, A. Mokashi, and A. K. Sherpa. Relationship between sympathetic and phrenic nerve response to peripheral chemoreflex in the cat. J. Auton. Nerv. Syst. 25: 95-105, 1988.
17. Januel, B., D. Laude, J. L. Elghozi, and P. Escourrou. Effect of autonomic blockade on heart rate and blood pressure in sleep apnea syndrome. Blood Press. 4: 226-231, 1995.
18. Katragadda, S., A. Xie, D. Puleo, J. B. Skatrud, and B. J. Morgan. Neural mechanism of the pressor response to obstructive and nonobstructive apnea. J. Appl. Physiol. 83: 2048-2054, 1997.
19. Leuenberger, U., E. Jacob, L. Sweer, N. Waravdekar, C. Zwillich, and L. Sinoway. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxia. J. Appl. Physiol. 79: 581-588, 1995.
20. Mancia, G., G. Grassi, G. Parati, and A. Daffonchio. Evaluating sympathetic activity in human hypertension. J. Hypertens. 11: S13-S19, 1993.
21. Masking, G. L., M. D. Esler, G. L. Jenings, D. Burdon, J. A. Johns, and P. I. Korner. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 73: 615-621, 1986.
22. Mitchell, J. M., and R. F. Schmidt Cardiovascular reflex control by afferent fibers from skeletal muscle receptors. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 2, chapt. 17, p. 623-658.
23. Mojet, M. H., E. Willis, and M. R. Duchen. Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration. J. Physiol. (Lond.) 504: 175-189, 1997.
24. Morgan, B. J. Acute and chronic cardiovascular responses to sleep disordered breathing. Sleep 19: S206-S209, 1996.
25. Morgan, B. J., T. Denahan, and T. J. Ebert. Neurocirculatory consequences of negative intrathoracic pressure vs. asphyxia during voluntary apnea. J. Appl Physiol. 74: 2969-2975, 1993.
26. Ninomiya, I., A. Irasawa, and N. Nisimaru. Nonuniformity of sympathetic nerve activity to the skin and kidney. Am. J. Physiol. 224: 256-264, 1973.
27. O'Donnell, C. P., T. Ayuse, E. D. King, A. R. Schwartz, P. L. Smith, and J. L. Robotham. Airway obstruction during sleep increases blood pressure without arousal. J. Appl. Physiol. 80: 773-781, 1996.
28. O'Donnell, C. P., A. R. Schwartz, P. L. Smith, J. L. Robotham, R. S. Fitzgerald, and M. Shirahata. Reflex stimulation of renal sympathetic nerve activity and blood pressure in response to apnea. Am. J. Respir. Crit. Care Med. 154: 1763-1770, 1996.
29. Ponte, J., and C. L. Sadler. Studies on the regenerated carotid sinus nerve of the rabbit. J. Physiol. (Lond.) 410: 411-424, 1989.
30. Rao, P. S., N. Rujikarn, and J. Luber, Jr. A specific sensitive HPLC method for determination of plasma dopamine. Chromatography 28: 309-312, 1989.
31. Scharf, S. M. The effect of decreased intrathoracic pressure on ventricular function. J. Sleep Res. 4: S53-S58, 1995.
32. Schneider, H., C. D. Schaub, K. A. Andreoni, A. R. Schwartz, P. L. Smith, J. L. Robotham, and C. P. O'Donnell. Systemic and pulmonary hemodynamic responses to normal and obstructed breathing during sleep. J. Appl. Physiol. 83: 1671-1680, 1997.
33. Schömig, A. Catecholamines in myocardial ischemia. Systemic and cardiac release. Circulation 82: II-13-II-22, 1990.
34. Seals, D. R., N. O. Suwarno, and J. A. Dempsey. Influence of lung volume on sympathetic nerve discharge in normal humans. Circ. Res. 67: 130-141, 1990.
35. Shykoff, B. E., S. S. Naqvi, A. S. Menon, and A. S. Slutsky. Respiratory sinus arrhythmia in dogs: effects of phasic afferents and chemostimulation. J. Clin. Invest. 87: 1621-1627, 1991.
36. Slamowitz, D., L. Chen, and S. M. Scharf. Effects of vagotomy on cardiovascular response to periodic apneas (Abstract). Am. J. Respir. Crit. Care Med. 157: A775, 1998.
37. Somers, V. K., M. E. Dyken, M. P. Clary, and R. M. Abboud. Sympathetic neural mechanisms in obstructive sleep apnea. J. Clin. Invest. 96: 1897-1904, 1995.
38. Somers V. K., A. L. Mark, D. C. Zavala, and F. M. Abboud. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J. Appl. Physiol. 67: 2101-2106, 1989.
39. Stoohs, R., and C. Guilleminault. Cardiovascular changes associated with obstructive sleep apnea syndrome. J. Appl. Physiol. 72: 583-589, 1992.
40. Tarasiuk, A., and S. M. Scharf. Mechanisms of circulatory depression during simulated central apneas in the anesthetized dog. Rev. Clin. Basic Pharmacol. 5: 253-268, 1994.
41. Tarasiuk, A., and S. M. Scharf. Cardiovascular effects of periodic obstructive and central apnoeas in dogs. Am. J. Respir. Crit. Care Med. 150: 83-89, 1994.
42. Von Euler, U. S. Quantitation of stress by catecholamine analysis. Clin. Pharmacol. Ther. 5: 398-404, 1964.
43. Westfaal, T. C. Ganglionic blocking agents. In: Modern Pharmacology (4th ed.), edited by C. R. Craig and R. E. Stitzel. Boston: Little Brown, 1994, p. 169-175.
44. Ziegler, M. G., R. Nelesen, P. Milis, S. Ancoli-Israel, B. Kennedy, and J. E. Dimsdale. Sleep apnea, norepinephrine-release rate, and daytime hypertension. Sleep 20: 224-231, 1997.
45. Zwillich, C., T. Devlin, D. White, N. Douglas, J. Weil, and R. Martin. Bradycardia during sleep apnea. Characteristics and mechanism. J. Clin. Invest. 69: 1286-1292, 1982.