Long-acting versus short-acting cephalosporins for preoperative prophylaxis in breast surgery: A randomized double-blind trial involving 1766 patients

Chemotherapy

Volumn 45, Issue 3, 1999, Pages 217-223

  Thomas, R ^a,b   Alvino, P ^b   Cortino, G R ^a   Accardo, R ^b   Rinaldo, M ^a   Pizzorusso, M ^a   Cesareo, E ^a   D'Aiuto, G ^a  

^a Division 'A' Breast Cancer Unit   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Breast surgery; Ceftazidime; Ceftriaxone; Infection; Preoperative prophylaxis

Indexed keywords

CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE;

ADULT; AGED; ANESTHESIA INDUCTION; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BREAST SURGERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HEALTH CARE COST; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MENTAL DISEASE; MORBIDITY; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WOUND INFECTION;

ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORINS; CHEMISTRY, PHARMACEUTICAL; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; ITALY; MASTECTOMY, RADICAL; MIDDLE AGED; PREOPERATIVE CARE; PROSPECTIVE STUDIES; SURGICAL WOUND INFECTION;

EID: 0032907647     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007186     Document Type: Article

References (21)

1. Platt R, Zucker JR, Zaleznik DF, Hopkins CC, Dillinger EP, Karchmer AW, et al: Perioperative antibiotic prophylaxis and wound infection following breast surgery. J Antimicrob Chemother 1993; 31(suppl B):43-48.
2. Bertin ML, Crowe J, Gordon SM: Determinants of surgical site infection after breast surgery. Am J Infect Control 1998;26:61-65.
3. Rotstein C, Ferguson R, Cummings KM, Piedmonte MR, Lucey J, Banish A: Determinants of clean surgical wound infections for breast procedures at an oncological center. Infect Control Hosp Epidemiol 1992; 13:207-214.
4. Lynch W, Malek M, Davey PG, et al: Costing wound infections in a Scottish hospital. Pharmacoeconomics 1992;2:163-170.
5. Bergquist EJ, Murphey SA: Prophylactic antibiotics for surgery. Med Clin North Am 1987;71:357-368.
6. Condon RE, Wittmann DH: The use of antibiotics in general surgery. Curr Probl Surg 1991;28:803-907.
7. Lewis RT, Weigand FM, Mamazza J, Lloyd-Smith W, Tataryn D: Should antibiotic prophylaxis be used routinely in clean surgery procedures: A tentative yes. Surgery 1995;118:742-747.
8. Platt R, Zucker JR, Zaleznick DF, Hopkins CC, Dellinger EP, Karchmer AW, et al: Prophylaxis against wound infection following herniorraphy or breast surgery. J Infect Dis 1992;166:556-560.
9. Anonymous: Antimicrobial prophylaxis in surgery. Med Lett Drugs Ther 1992;34:5-8.
10. Hell K: How to choose antimicrobials for surgical prophylaxis. J Chemother 1989;1:24-29.
11. Kaiser AB: Antimicrobial prophylaxis in surgery. N Engl J Med 1986; 315:1129-1138.
12. Lippert H, Gastinger J: Antimicrobial prophylaxis in laparoscopic and conventional cholecystectomy. Conclusion of a large prospective multi-center quality assurance study in Germany. Chemotherapy 1998;44: 335-363.
13. Ross CB, Wheeler WG 2nd, Jones MJ, Kerins CA, Peek TE: Ceftriaxone versus cefazolin in peripheral arterial operations: A randomized, prospective trial. South Med J 1997; 90:16-22.
14. Sisto T, Laurikka J, Tarkka MR: Ceftriaxone vs cefuroxime for infection prophylaxis in coronary bypass surgery. Scand J Thorac Cardiovasc Surg 1994;28:143-148.
15. Goldberg DM: The cephalosporins. Med Clin North Am 1987;71:1113-1133.
16. Klein NC, Cunha BA: Third-generation cephalosporins. Med Clin North Am 1995;79:705-719.
17. Fletcher CV, Metzler D, Borchardt-Phelps P, Rodman JH: Patterns of antibiotic use and expenditures during 7 years at a university hospital. Pharmacotherapy 1990;10:199-204.
18. Roach Ac, Kernodle DS, Kaiser AB: Selecting cost-effective antimicrobial prophylaxis in surgery: Are we getting what we pay for? DICP 1990;24:183-185.
19. Davey P, Malek M, Thomas P: Measuring the cost-effectiveness of antibiotic prophylaxis in surgery. Am J Surg 1992;164(suppl 4A):39-43.
20. Klein WR, Firth EC: Infection rates in clean surgical procedures with and without prophylactic antibiotics. Vet Rec 1988;123:542-543.
21. Bergamini TM, Polk HC Jr: The importance of tissue antibiotic activity in the prevention of operative wound infection. J Antimicrob Chemother 1989;23:301-313.