Sympathetic activity and aging: Relationship to smoking habits, physical fitness, blood volume, and intracellular signalling

Danish Medical Bulletin

Volumn 46, Issue 2, 1999, Pages 106-117

  Jensen, Ebbe Winther ^a  

^a NONE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CALCIUM;

ADRENALIN BLOOD LEVEL; ADULT; AGED; AGING; ARTICLE; BLOOD PRESSURE; BLOOD VOLUME; CALCIUM CELL LEVEL; EXERCISE; FITNESS; HEART OUTPUT; HEMODYNAMICS; HUMAN; LYMPHOCYTE; MALE; NORADRENALIN RELEASE; SIGNAL TRANSDUCTION; SMOKING HABIT; SYMPATHETIC TONE;

ADOLESCENT; AGED; AGING; BLOOD VOLUME; HABITS; HUMANS; MALE; PHYSICAL FITNESS; REFERENCE VALUES; SIGNAL TRANSDUCTION; SMOKING; SYMPATHETIC NERVOUS SYSTEM;

EID: 0032907481     PISSN: 09078916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (135)

1. Abrass I.B. & Scarpace P.J. (1982) Catalytic unit of adenylate cyclase: Reduced activity in aged human lymphocytes. J Clin Endocrinol Metab, 55, 1026-1028.
2. Astrup A., Christensen N.J. & Breum L. (1991) Reduced plasma noradrenaline concentrations in simple-obese and diabetic obese patients. Clin Sci, 80, 53-58.
3. Benarroch E.E. (1994) Neuropeptides in the sympathetic system: presence, plasticity, modulation, and implications. Ann Neurol, 36, 6-13.
4. Bent-Hansen L. (1991) Initial plasma disappearance and tissue uptake of 131-I-albumin in normal rabbits. Microvasc Res, 41, 345-356.
5. Bodmer C.W., Valentine D.T., Masson E.A., Savage M.W., Lake D. & Williams G. (1994) Smoking attenuates the vasoconstrictor response to noradrenaline in type I diabetic patients and normal subjects: possible relevance to diabetic nephropathy. Eur J Clin Invest, 24, 331-336.
6. Born GV. (1994) New determinants of the uptake of atherogenic plasma proteins by arteries. Basic Research in Cardiology, 89, 103-106.
7. Brandsborg O., Christensen N.J., Galbo H., Brandsborg M. & Lovgreen N.A. (1978) The effect of exercise, smoking and propranolol on serum gastrin in patients with duodenal ulcer and in vagotomized subjects. Scand J Clin Lab Invest, 38, 441-446.
8. Brodde O.-E., Kretsch R., Ikezono K., Zerkowski H.-R. & Reidemeister J.C. (1986) Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density. Science, 231, 1584-1585.
9. Carlson J.T., Hedner J., Elam M., Ejnell H., Sellgren J. & Wallin B.G. (1993) Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest, 103, 1763-1768.
10. Christensen N.J. (1973) Plasma noradrenaline and adrenaline in patients with thyrotoxicosis and myxoedema. Clin Sci Mol Med, 45, 163-171.
11. Christensen N.J., Vestergaard P., Soerensen T. & Rafaelsen O.J. (1980) Cerebrospinal fluid adrenaline and noradrenaline in depressed patients. Acta Psychiatr Scand, 61, 178-182.
12. Christensen N.J. (1986) Is plasma noradrenaline an index of biological age?. In The sympathoadrenal system. Physiology and pathophysiology. Eds N.J. Christensen, O. Henriksen & N.A. Lassen. Munksgaard: Copenhagen, pp. 266-272.
13. Christensen N.J. (1991) The biochemical assessment of sympathoadrenal activity in man. Clin Autonom Res, 1, 167-172.
14. Christensen N.J. & Henriksen J.H. (1991) Degradation of endogenous catecholamines. In Degradation of bioactive substances. Physiology and pathophysiology. Ed J.H. Henriksen. Florida, USA: CRC Press Inc., Boca Raton. pp. 289-305.
15. ChristenseN N.J. & Schultz-Larsen K. (1994) Resting venous plasma adrenaline in 70-year-old men correlated positively to survival in a population study: the significance of the physical working capacity. J Intern Med, 235, 229-232.
16. Coffman J.D. & Javett S.L. (1963) Blood flow in the human calf during tobacco smoking. Circulation, 28, 932-937.
17. Cryer P.E., Haymond M.W., Santiago J.V. & Shah S.D. (1976) Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med, 295, 573-577.
18. Davidson L., Vandongen R., Rouse I.L., Beilin L.J. & Tunney A. (1984) Sex-related differences in resting and stimulated plasma noradrenaline and adrenaline. Clin Sci, 67, 347-352.
19. Davy K.P., Johnson D.G. & Seals D.R. (1995) Cardiovascular, plasma norepinephrine, and thermal adjustments to prolonged exercise in young and older healthy humans.. Clin Physiol, 15, 169-181.
20. De Lorgeril M, Reinharz A., Busslinger B., Reber G. & Righetti A. (1985) Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life. Eur Heart J, 6, 1063-1068.
21. Diana J.N., Qian S., Heesch C.M., Barron K.W. & Chien C.-Y. (1990) Nicotine-induced skeletal muscle vasodilation is mediated by release of epinephrine from nerve terminals. Am J Physiol, 259, H1718-H1729.
22. Dietz R., Schomig A., Kusterer K., Dart A.M. & Kubler W. (1984) Vasopressor systems during smoking in humans. Klin Wochenschr, 62 Suppl 2, 11-17.
23. Dillon N., Chung S., Kelly J. & O'Malley K. (1980) Age and beta-adrenoceptor-mediated function. Clin Pharmacol Ther, 27, 769-772.
24. Doyle J.T., Dawber T.R., Kannel W.B., Heslin A.S. & Kahn H.A. (1962) Cigarette smoking and coronary heart disease. N Engl J Med, 266, 796-801.
25. Eckberg D.L., Rea R.F., Andersson O.K., Hedner T., Perno W J., Lundberg J.M. & Wallin B.G. (1988) Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans. Acta Physiol Scand, 133, 221-231.
26. Esler M., Skews H., Leonard P., Jackman G, Bobik A. & Korner P. (1981) Age-dependence of noradrenaline kinetics in normal subjects. Clin Sci (Colch), 60, 217-219.
27. Espersen K., Jensen E.W., Rosenborg D., Thomsen J.K., Eliasen K., Olsen N.V. & Kanstrup I.-L. (1995) Comparison of cardiac output measurement techniques: Thermodilution, Doppler, CO2-rebreathing and the direct Fick method. Acta Anaesthesiol Scand, 39, 245-251.
28. Fagius J., Niklasson F. & Berne C. (1986) Sympathetic outflow in human muscle nerves increaes during hypoglycemia. Diabetes, 35, 1124-1129.
29. Feldman R.D., Limbird L.E., Nadeau J., Robertson D. & Wood A.J. (1984) Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly. N Engl J Med, 310, 815-819.
30. Feldt-Rasmussen B. (1986) Increased transcapillary escape rate of albumin in type I (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia, 29, 282-286.
31. Felten S.Y., Felten D.L., Bellinger D.L. & Olschowka J.A. (1992) Noradrenergic and peptidergic innervation of lymphoid organs. Neuroendocrinology, 52, 25-48.
32. Fleg J.L., Tzankoff S.P. & Lakatta E.G. (1985) Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males. J. Appl Physiol, 59, 1033-1039.
33. Fogh-Andersen N., Thomsen J.K., Foldager N. & Siggaard-Andersen O. (1990) pH effect on the COHb absorption spectrum: Importance for calibration of the OSM3 and measurement of circulating hemoglobin and blood volume. Scand J Clin Lab Invest, 50 (suppl 203), 247-252.
34. Fowkes F.G.R. (1989) Aetiology of peripheral atherosclerosis. Br Med J, 298, 405-406.
35. Gietzen D.W., Goodman T.A., Weiler P.G., Graf K., Fregeau D.R., Magliozzi J.R., Doran A.R. & Maddock R.J. (1991) Beta receptor density in human lymphocyte membranes: changing with aging?. J Gerontol, 46, B130-B134.
36. Gosling P., Shearman C.P. & Beevers D.G. (1990) Urinary albumin excretion in smokers and non-smokers. Contr Nephrol, 83, 151-155.
37. Grassi G, Seravalle G, Calhoun D., Bolla G.B. & Mancia G. (1992a) Physical exercise in essential hypertension. Chest, 101, 312S-314S.
38. Grassi G, Seravalle G, Calhoun D.A., Bolla G. & Mancia G. (1992b) Cigarette smoking and the adrenergic nervous system. Clin Exp Hypertens A, 14, 251-260.
39. Grassi G, Seravalle G, Calhoun D.A., Bolla G.B., Giannattasio C., Marabini M., Del Bo A. & Mancia G. (1994) Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation, 90, 248-253.
40. Hagberg J.M., Goldring D., Heath GW., Ehsani A.A., Hernandez A. & Holloszy J.O. (1984) Effect of exercise training on plasma catecholamines and haemodynamics of adolescent hypertensives during rest, submaximal exercise and orthostatic stress. Clin Physiol, 4, 117-124.
41. Hagberg J.M., Seals D.R., Yerg J.E., Gavin J., Gingerich R., Premachandra B. & Holloszy J.O. (1988) Metabolic responses to exercise in young and older athletes and sedentary men. J Appl Physiol, 65, 900-908.
42. Hakanson R., Wahlestedt C., Ekblad E., Edvinsson L. & Sundler F. (1986) Neuropeptide Y: coexistence with noradrenaline. Functional implications. Prog Brain Res, 68, 279-287.
43. Hauss W.H., Bauch H.J. & Schulte H. (1990) Adrenaline and noradrenaline as possible chemical mediators in the pathogenesis of arteriosclerosis. Ann N Y Acad Sci, 598, 91-101.
44. Hickson R.C., Hagberg J.M., Conlee R.K., Jones D.A., Ehsani A.A. & Winder W.W. (1979) Effect of training on hormonal responses to execise in competitive swimmers. Eur J Appl Physiol, 41, 211-219.
45. Hilsted J., Christensen N.J. & Larsen S. (1985) Plasma clearance of noradrenaline does not change with age in normal subjects. Clin Physiol, 5, 443-446.
46. Hjemdahl P., Fagius J., Freyschuss U., Wallin B.G., Daleskog M., Bohlin G. & Perski A. (1989) Muscle sympathetic activity and norepinephrine release during mental challenge in humans. Am J Physiol, 257, E654-E664.
47. Hoeldtke R.D. & Cilmi K.M. (1985) Effects of aging on catecholamine metabolism. J Clin Endocrinol Metab, 60, 479-484.
48. Howard G., Burke G.L., Szklo M., Tell G.S., Eckfeldt J., Evans G. & Heiss G. (1994) Active and passive smoking are associated with increased carotid wall thickness. The Atherosclerosis Risk in Communities Study. Arch Intern Med, 154, 1277-1282.
49. Jensen E.W., Bryde Andersen H., Nielsen S.L. & Christensen N.J. (1992a) Long-term smoking increases transcapillary escape rate of albumin. Scand J Clin Lab Invest, 52, 653-656.
50. Jensen E.W., Espersen K., Kanstrup I.L. & Christensen N.J. (1992b) Age-related changes of exercise-induced plasma catecholamines and neuropeptide Y responses in normal human subjects. Acta Physiol Scand, 144, 129-133.
51. Jensen E.W., Eldrup E., Kelbaek H., Nielsen S.L. & Christensen N.J. (1993) Venous plasma noradrenaline increases with age: correlation to total blood volume and long-term smoking habits. Clin Physiol, 13, 99-109.
52. Jensen E.W., Espersen K., Kanstrup I.L. & Christensen N.J. (1994) Exercise-induced changes in plasma catecholamines and neuropeptide Y: relation to age and sampling times. J Appl Physiol, 76, 1269-1273.
53. Jensen E.W., Bouchelouche P. & Christensen N.J. (1995a) Catecholamine responsiveness in human lymphocytes evaluated by intracellular free calcium measurements. Scand J Clin Lab Invest, 55, 559-569.
54. Jensen E.W., Espersen K., Kanstrup I.-L. & Christensen N.J. (1995b) Basal and exercise-induced changes in plasma catecholamines: relationship to age, smoking habits and sampling times. Clin Physiol, 15, 299-305.
55. Jensen E.W., Espersen K., Knudsen J.H. & Nielsen S.L. (1995c) Increased transcapillary escape rate of albumin in elderly subjects due to long-term smoking habits. Clin Physiol, 15, 159-167.
56. Jensen E.W., Espersen K., Kanstrup I.-L. & Christensen N.J. (1996) Plasma noradrenaline and ageing: effects of smoking habits. Eur J Clin Invest, 26, 839-846.
57. Kannel W.B. (1974) Role of blood pressure in cardiovascular morbidity and mortality. Prog Cardiovasc Dis, 17, 5-24.
58. Kaplan J.R., Pettersson K., Manuck S.B. & Olsson G. (1991) Role of sympathoadrenal medullary activation in the initiation and progression of atherosclerosis. Circulation, 84, VI23-VI32.
59. Kappel M., Tvede N., Galbo H., Haahr P.M., Kjaer M., Linstow M., Klarlund K. & Pedersen B.K. (1991) Evidence that the effect of physical exercise on NK cell activity is mediated by epinephrine. J Appl Physiol, 70, 2530-2534.
60. Kastello G.M., Sothmann M.S. & Murthy V.S. (1993) Young and old subjects matched for aerobic capacity have similar noradrenergic responses to exercise. J Appl Physiol, 74, 49-54.
61. Kelbaek H., Hartling O.J., Gjoerup T., Marving J., Christensen N.J. & Godtfredsen J. (1987) Effect of autonomic blockade on cardiac function at rest and during upright exercise in humans. J Appl Physiol, 63, 554-557.
62. Kelbaek H., Bulow K., Aldershvile J., Moegelvang J. & Nielsen S.L. (1989) A new 99m-Tc red blood cell labeling procedure for cardiac blood pool imaging: Clinical results. Eur J Nucl Med, 15, 333-335.
63. Kimura S., Nishinaga M., Ozawa T. & Shimada K. (1994) Thrombin generation as an acute effect of cigarette smoking. Am Heart J, 128, 7-11.
64. Kjaer M., Christensen N.J., Sonne B., Richter E.A. & Galbo H. (1985) Effect of exercise on epinephrine turnover in trained and untrained male subjects. J Appl Physiol, 59, 1061-1067.
65. Kjaer M., Farrell P.A., Christensen N.J. & Galbo H. (1986) Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol, 61, 1693-1700.
66. Kjaer M. (1989) Epinephrine and some other hormonal responses to exercise in man: with special reference to physical training. Int J Sports Med, 10, 2-15.
67. Knudsen J.H., Court-Payen M., Kjærsgaard E. & Christensen N.J. (1995a) Lymphocyte subset composition in peripheral blood from normal subjects may be influenced by both spleen size and plasma norepinephrine. Scand J Clin Lab Invest, 55, 643-648.
68. Knudsen J.H., Kjaersgaard E. & Christensen N.J. (1995b) Individual lymphocyte subset composition determines cAMP response to isoproterenol in mononuclear cell preparations from peripheral blood. Scand J Clin Lab Invest, 55, 9-14.
69. Knudsen J.H., Gustafsson F., Toft J. & Christensen N.J. (1997) Lymphocyte cAMP and aging: significance of subset composition, plasma noradrenaline, and regular physical training and long-term smoking. Clin Sci, In press,
70. Kohrt W.M., Spina R.J., Ehsani A.A., Cryer P.E. & Holloszy J.O. (1993) Effects of age, adiposity, and fitness level on plasma catecholamine responses to standing and exercise. J Appl Physiol, 75, 1828-1835.
71. Krall J.F., Connelly M., Weisbart R. & Tuck ML. (1981) Age-related elevation of plasma catecholamine concentration and reduced responsiveness of lymphocyte adenylate cyclase. J Clin Endocrinol Metab, 52, 863-867.
72. Lakatta E.G. & Yin F.C.P. (1982) Myocardial ageing: functional alterations and related cellular mechanisms. Am J Physiol, 242, H927-H941.
73. Landmann R. (1992) Beta-adrenergic receptors in human leucocyte subpopulations. Eur J Clin Invest, 22, Suppl. 1, 30-36.
74. Larsen K.R., Milman N., Svendsen U.G. & Petersen B.N. (1995) Reproducibility of gas exchange and respiratory parameters in a modern exercise testing devise. Eur Respir J, 8, suppl. 19, 244(Abstract)
75. Laustiola K.E., Lassila R., Kaprio J. & Koskenvuo M. (1988) Decreased beta-adrenergic receptor density and catecholamine response in male cigarette smokers. A study of monozygotic twin pairs discordant for smoking. Circulation, 78, 1234-1240.
76. Laustiola K.E., Kotamaki M., Lassila R., Kallioniemi O.P. & Manninen V. (1991) Cigarette smoking alters sympathoadrenal regulation by decreasing the density of beta 2-adrenoceptors. A study of monitored smoking cessation. J Cardiovasc Pharmacol, 17, 923-928.
77. Lehmann M. & Keul J. (1986) Age-associated changes of exercise-induced plasma catecholamine responses. Eur J Appl Physiol, 55, 302-306.
78. Liggett S.B., Marker J.C., Shah S.D., Roper C.L. & Cryer P.E. (1988) Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans. J Clin Invest, 82, 48-56.
79. Lindell G, Farnebo L.O., Chen D., Nexo E., Rask Madsen J., Bukhave K. & Graffner H. (1993) Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids. Scand J Gastroenterol, 28, 487-494.
80. Lipsitz L A., Ryan S.M., Parker A., Freeman R., Wei J.Y. & Goldberger A.L. (1993) Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension. Circulation, 87, 391-400.
81. Mader S.L., Robbins A.S., Rubenstein L.Z., Tuck ML. & Scarpace P.J. (1988) Effect of age and posture on human lymphocyte adenylate cyclase activity. Clin Sci (Colch), 74, 331-334.
82. Maisel A.S., Harris T., Rearden C.A. & Michel M.C. (1990) Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure. Circulation, 82, 2003-2010.
83. Martin M.J., Hulley S.B., Browner W.S., Kuller L.H. & Wenteworth D. (1986) Serum cholesterol, blood pressure and mortality: implications from a cohort of 361662 men. Lancet, ii, 933-936.
84. Meade T.W., Mellows S., Brozovic M., Miller G.J., Chakrabarti R.R., North W.R.S., Haines A.P., Stirling Y., Imeson J.D. &Thompson S.G. (1986) Haemostatic function and ischaemic heart disease. Principal results of the Northwick Park Heart Study. Lancet, ii, 533-537.
85. Meade T.W., Imeson J. & Stirling Y. (1987) Effects of changes in smoking and other characteristics on clotting factors and the risk of ischaemic heart disease. Lancet, ii, 986-988.
86. Metcalf P., Baker J.R., Scragg R.K.R., Dryson E., Scott A.J. & Wild C.J. (1993) Albuminuria in people at least 40 years old: effect of alcohol consumption, regular exercise and cigarette smoking. Clin Chem, 39, 1793-1797.
87. Michel M.C., Beckeringh J.J., Ikezono K., Kretsch R. & Brodde O.-E. (1986) Lymphocyte beta-2-adrenoceptors mirror precisely beta-2-adrenoceptor, but poorly beta-1-adrenoceptor changes in the human heart. J Hypertens, 4, S215-S218.
88. Morlin C., Wallin B.C. & Eriksson B.M. (1983) Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive man. Acta Physiol Scand, 119, 117-121.
89. Murray D.R., Irwin M., Rearden C.A., Ziegler M., Motulsky H. & Maisel A.S. (1992) Sympathetic and immune interactions during dynamic exercise. Mediation via a beta-2-adrenergic-dependent mechanism. Circulation, 86, 203-213.
90. Myers M.G., Benowitz N.L., Dubbin J.D., Haynes R.B. & Sole M.J. (1988) Cardiovascular effects of smoking in patients with ischemic heart disease. Chest, 93, 14-19.
91. Ng A.V., Callister R., Johnson D.G. & Seals D.R. (1993) Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension, 21, 498-503.
92. NG A.V., Callister R., Johnson D.G. & Seals D.R. (1994) Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans. J Appl Physiol, 77, 1366-1374.
93. Niedermaier O.N., Smith M.L., Beightol L.A., Zukowska-Groje C Z., Goldstein D.S. & ECkberG D.L. (1993) Influence of cigarette smoking on human autonomic function. Circulation, 88, 562-571.
94. Nieman D.C., Henson D.A., Johnson R., Lebeck L., Davis J.M. & Nehlsen-Cannarella S.L. (1992) Effects of brief, heavy exertion on circulating lymphocyte subpopulations and proliferative response. Med Sci Sports Exerc, 24, 1339-1345.
95. Olsson T., Viitanen M., Hagg E., Asplund K., Grankvist K., Eriksson S. & Gustafson Y. (1991) Catecholamine excretion in old age. Aging (Milano), 3, 263-268.
96. Omvik P. (1996) How smoking affects blood pressure. Blood Pressure, 5, 71-77.
97. Paaske W. (1983) Microvascular exchange of albumin. Microvasc Res, 25, 101-107.
98. Palmer G.J., Ziegler M.G. & Lake C.R. (1978) Response of norepinephrine and blood pressure to stress increases with age. J Gerontol, 33, 482-487.
99. Parving H.-H., Rossing N., Nielsen S.L. & Lassen N.A. (1974) Increased transcapillary escape rate of albumin, IgG, and IgM after plasma volume expansion. Am J Physiol, 227, 245-250.
100. Parving H.-H. & Rossing N. (1973) Simultaneous determination of the transcapillary escape rate of albumin and IgG in normal and long-term juvenile diabetic subjects. Scand J Clin Lab Invest, 32, 239-244.
101. Peronnet F., Cleroux J., Perrault H., Cousineau D., De Champlain J. & Nadeau R. (1981) Plasma norepinephrine response to exercise before and after training in humans. J Appl Physiol, 51, 812-815.
102. Poehlman E., Gardner A., Goran M., Arciero P., Toth M., Ades P. & Calles Escandon J. (1995) Sympathetic nervous system activity, body fatness, and body fat distribution in younger and older males. Journal of Applied Physiology 78(3): 802-806, 802-806.
103. Poehlman E.T., Mcauliffe T. & Danforth E., JR. (1990) Effects of age and level of physical activity on plasma norepinephrine kinetics. Am J Physiol, 258, E256-E262.
104. Poehlman E.T. & Danforth E., JR. (1991) Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals. Am J Physiol, 261, E233-E239.
105. Prinz P.N., Halter J., Benedetti C. & Raskind M. (1979) Circardian variation of plasma catecholamines in young and old men: relation to rapid eye movement and slow wave sleep. J Clin Endocrinol Metab, 49, 300-304.
106. Raskind M.A., Peskind E.R., Veith R.C., Beard J.C., Gumbrecht G. & Halter J.B. (1988) Increased plasma and cerebrospinal fluid norepinephrine in older men: differential suppression by clonidine. J Clin Endocrinol Metab, 66, 438-443.
107. Reynolds V., Jenner D.A., Palmer C.D. & Harrison G.A. (1981) Catecholamine excretion rates in relation to life-styles in the male population of Otmoor, Oxfordshire. Ann Hum Biol, 8, 197-209.
108. Ross R. (1986) The pathogenesis of atherosclerosis - an update. N Engl J Med, 314, 488-500.
109. Rottenstein H., Peirce G, Russ E. & Felder D.J. (1959) Effefct of nicotine on muscle blood flow in man. Circulation, 20, 760
110. Sachs C., Hamberger B. & Kaijser L. (1985) Cardiovascular responses and plasma catecholamines in old age. Clin Physiol, 5, 553-565.
111. Saelsen L., Andersen H.B., Bratholm P. & Christensen N.J. (1994) Radioimmunoassay of plasma neuropeptide Y using HPLC for separation of related peptides and fragments. Scand J Clin Lab Invest, 54, 207-214.
112. SchedlowskI M., Falk A., Rohne A., Wagner T.O.F., Jacobs R., Tewes U. & Schmidt R.E. (1993) Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells. J Clin Immunol, 13, 344-351.
113. Schwartz R.S., Jaeger L.F. & Veith R.C. (1987) The importance of body composition to the increase in plasma norepinephrine appearance rate in elderly men. J Gerontol, 42, 546-551.
114. Schwartz R.S., Jaeger L.F. & Veith R.C. (1994) The thermic effect of feeding in older men: the importance of the sympathetic nervous system. Metabolism, 39, 733-737.
115. Siess W., Lorenz R., Roth P. & Weber P.C. (1982) Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. Circulation, 66, 44-48.
116. Supiano M.A., Linares O.A., Smith M.J. & Halter J.B. (1990) Age-related differences in norepinephrine kinetics: effect of posture and sodium-restricted diet. Am J Physiol, 259, E422-E431.
117. Svedenhag J., Martinsson A., Ekblom B. & Hjemdahl P. (1986) Altered cardiovascular responsiveness to adrenaline in endurance-trained subjects. Acta Physiol Scand, 126, 539-550.
118. Taylor J.A., Hand G.A., Johnson D.G. & Seals D.R. (1992) Augmented forearm vasoconstriction during dynamic exercise in healthy older men. Circulation, 86, 1789-1799.
119. Thomsen J.K., Fogh-Andersen N., Bulow K. & Devantier A. (1991) Blood and plasma volumes determined by carbon monoxide gas, 99m-Tc-labelled erythrocytes, 125-I-albumin and the T 1824 technique. Scand J Clin Lab Invest, 51, 185-190.
120. Toennesen E., Christensen N.J. & Brinkloev M.M. (1987) Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers. Eur J Clin Invest, 17, 497-503.
121. Trap-Jensen J., Carlsen J.E., Svendsen T.L. & Christensen N.J. (1979) Cardiovascular and adrenergic effects of cigarette smoking during immediate non-selective and selective beta adrenoceptor blockade in humans. Eur J Clin Invest, 9, 181-183.
122. Trap-Jensen J. (1988) Effects of smoking on the heart and peripheral circulation. Am Heart J, 115, 258-263.
123. Troisi R.J., Weiss ST., Parker D.R., Sparrow D., Young J.B. & Landsberg L. (1991) Relation of obesity and diet to sympathetic nervous system activity. Hypertension, 17, 669-677.
124. Van Ravenswaaij-Arts C.M., Kollee L.A., Hopman J.C., Stoelinga G.B. & Van Geijn H.P. (1993) Heart rate variability. [Review]. Ann Intern Med, 118, 436-447.
125. Van Tits L.J.H., Michel M.C., Grosse-Wilde H., Happel M., Eigler F.-W., Soliman A. & Brodde O.-E. (1990) Catecholamines increase lymphocyte beta-2-adrenergic receptors via a beta-2-adrenergic spleen-dependent process. Am J Physiol, 258, E191-E202.
126. Veith R.C., Featherstone J.A., LinareS O.A. & Halter J.B. (1986) Age differences in plasma norepinephrine kinetics in humans. J Gerontol, 41, 319-324.
127. Wallin B.G., Sundlof G, Eriksson B.-M., Dominiak P., Grobecker H. & Lindblad L.E. (1931) Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiol Scand, 111, 69-73.
128. Weber F., Anlauf M. & Muller R.-D. (1989) Changes in muscle blood flow after smoking a cigarette determined by a new noninvasive method. Eur J Clin Pharmacol, 37, 517-520.
129. Whelan R.F. & De La Lande I.S. (1963) Action of adrenaline on limb blood flow. Br Med Bull, 19, 125-131.
130. Wilkie F.L., Halter J.B., Prinz P.N., Benedetti C., Eisdorfer C., Atwood B. & Yamasaki D. (1985) Age-related changes in venous catecholamines basally and during epinephrine infusion in man. J Gerontol, 40, 133-140.
131. Winder W.W., Hagberg J.M., Hickson R.C., Ehsani A.A. & Mclane J.A. (1978) Time course of sympathoadrenal adaption to endurance exercise training in man. J Appl Physiol, 45, 370-374.
132. Winder W.W., Hickson R.C., Hagberg J.M., Ehsani A.A. & Mclane J.A. (1979) Training-induced changes in hormonal and metabolige responses to submaximal exercise. J Appl Physiol, 46, 766-771.
133. Winniford M.D. (1990) Smoking and cardiovascular function. J Hypertens Suppl, 8, S17-S23.
134. Zahniser N.R., Wiser A., Cass W.A., Curella P., Gerber J.G. & Nies A.S. (1992) Terbutaline-induced desensitization of polymorphonuclear leukocyte beta 2-adrenergic receptors in young and elderly subjects. Clin Pharmacol Ther, 51, 432-439.
135. Ziegler M.G., Lake C.R. & Kopin I.J. (1976) Plasma noradrenaline increases with age. Nature, 261, 333-335.