The oncogenic 30 and 69 bp deletion variants of the EBV LMP-1 gene are common in HIV-negative lymphoproliferations, both malignant and benign

Annals of Oncology

Volumn 10, Issue 4, 1999, Pages 467-469

  Barozzi, P ^b   Luppi, M ^b   Cagossi, K ^b   Maiorana, A ^b   Marasca, R ^b   Artusi, T ^b   Poggi, S ^b   Pileri, S A ^b   Torelli, G ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b NONE

Author keywords

Epstein Barr virus; LMP 1; Lymphoid disorders

Indexed keywords

LATENT MEMBRANE PROTEIN 1;

ARTICLE; EPSTEIN BARR VIRUS; HUMAN; HUMAN TISSUE; LEUKEMIA; LYMPH NODE BIOPSY; LYMPH NODE HYPERPLASIA; LYMPHADENITIS; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS CARCINOGENESIS; VIRUS ONCOGENE;

BIOPSY; GENE DELETION; GENE FREQUENCY; HERPESVIRUS 4, HUMAN; HIV SERONEGATIVITY; HUMANS; LYMPH NODES; LYMPHOPROLIFERATIVE DISORDERS; MEMBRANE PROTEINS; ONCOGENE PROTEINS, VIRAL; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 0032907444     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008381006612     Document Type: Article

References (6)

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2. Luppi M, Barozzi P, Marasca R et al. Frequent detection of human herpesvirus-6 sequences by polymerase chain reaction in paraffin-embedded lymph nodes from patients with angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Leuk Res 1993; 17: 1003-11.
3. Knecht H, Bachmann E, Brousset P et al. Mutational hot spots within the carboxy terminal region of the LMP-1 oncogene of Epstein-Barr virus are frequent in lymphoproliferative disorders. Oncogene 1995; 10: 523-8.
4. Dolcetti R, Zancai P, De Re V et al. Epstein-Barr virus strains with latent membrane protein-1 deletions: Prevalence in the Italian population and high association with human immunodeficiency virus-related Hodgkin's disease. Blood 1997; 89: 1723-31.
5. Itakura O, Yamada S, Narita M et al. High prevalence of a 30-base pair deletion and single-base mutations within the carboxy terminal end of the LMP-1 oncogene of Epstein-Barr virus in the Japanese population. Oncogene 1996; 13: 1549-53.
6. Tacyildiz N, Cavdar AO, Ertem U et al. Unusually high frequency of a 69-bp deletion within the carboxy terminus of the LMP-1 oncogene of Epstein-Barr detected in Burkitt's lymphoma of Turkish children Leukemia 1998; 12: 1796-805.