Electrochemical generation and interaction study of the nitro radical anion from nimesulide

Pharmaceutical Research

Volumn 16, Issue 1, 1999, Pages 161-164

  Squella, J A ^a   Gonzalez, P ^a   Bollo, S ^a   Nunez Vergara L J ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Anion radical; Cyclic voltammetry; Nimesulide; Reduction

Indexed keywords

NIMESULIDE; NITRO DERIVATIVE; RADICAL;

ARTICLE; CYCLIC POTENTIOMETRY; DRUG DETERMINATION; DRUG SCREENING; ELECTROCHEMICAL ANALYSIS; ELECTROCHEMISTRY; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ELECTROCHEMISTRY; FEASIBILITY STUDIES; FREE RADICALS; NITRO COMPOUNDS; SULFONAMIDES; XENOBIOTICS;

EID: 0032906401     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011950218824     Document Type: Article

References (17)

1. R. Davis and R. N. Brogden. Nimesulide. An update of its pharmacodymamic properties and therapeutic efficacy. Drugs 48:431-454 (1994).
2. L. Ottonello, P. Dapino, M. C. Scirocco, A. Balbi, M. Berilacqua, and F. Dellegri. Sulfonamides as antiinflamatory agents-olds drugs for new therapeutic strategies in neutrophilic inflammation Clinical Science 88:331-336 (1995).
3. A. Alvarez-Lueje, P. Vasquez, L. J. Núñez-Vergara, and J. A. Squella. Voltammetric study of nimesulide and its differential pulse polarographic determination in pharmaceuticals. Electroanalysis 9:1209-1213 (1997).
4. P. Wardman and E. D. Clarke. Oxygen inhibition of nitroreductase: electron transfer from nitro radical anions to oxygen. Biochem. Biophys. Res. Comm. 69:942-949 (1976).
5. J. A. Squella, M. Huerta, S. Bollo, H. Pessoa, and L. J. Núñez-Vergara, Electrochemical reduction of nitrotetralones. J. Electroanal. Chem. 420:63-70 (1997).
6. R. S. Nicholson. Semiempirical procedure for measuring with stationary electrode polarography rates of chemical reactions involving the product of electron transfer. Analytical Chemistry 36:1406 (1964).
7. H. Lund in Cathodic Reduction of Nitro and Related Compounds, in Organic Electrochemistry, Ed. H. Lund and M. M. Baizer, p. 411, M. Dekker Inc. New York 3rd. Ed. (1990).
8. B. Kastening in Free Radicals in Organic Polarography; I. Nitro and nitroso compounds. from Progress in Polarography, Vol. 3 Ed. P. Zuman, L. Meites, and I. M. Kolthoff. J. Wiley & Sons, Inc. NY p. 259 (1972).
9. R. S. Nicholson and I. Shain. Theory of stationary electrode polarography Anal. Chem. 36: 706-723 (1964).
10. J. A. Squella, S. Bollo, J. de la Fuente, and L. J. Núñez-Vergara. Electrochemical study of the nitro radical anion from Nicardipine: Kinetic parameters and its interaction with glutathione. Bioelectrochem Bioenergetics 34:13-18 (1994).
11. M. L. Olmstead, R. G. Hamilton, and R. S. Nicholson. Theory of cyclic voltammetry for a dimerization reaction initiated electrochemically. Anal. Chem. 41:260-266 (1969).
12. L. J. Núñez-Vergara, F. García, M. M. Dominguez, J. de la Fuente, and J. A. Squella. In situ reactivity of the electrochemically generated nitro radical anion from nitrendipine with glutathione, adenine and uracil. J. Electroanal. Chem. 381: 215-219 (1995).
13. D. Scherling, W. Karl, G. Ahr, H. Ahr, and E. Wehinger. Pharmacokinetics of nisoldipine. III. Biotransformation of nisoldipine in rat, dog, monkey and man. Arzneim-Forsch/Drug Res. 38(11): 1105-1110 (1988).
14. D. Scherling, K. Büchner, P. Krause, W. Karl and C. Wunsche. Biotransformation of nimodipine in rat, dog and monkey. Arzneim-Forsch/Drug Res. 41(1):392-298 (1991).
15. R. J. Youngman, W. F. Osswald, and E. F. Elstner. Mechanisms of oxygen activation by nitrufurantoin and relevance to its toxicity. Biochem. Pharnacol. 31:3723-3729 (1982).
16. L. J. Núñez-Vergara, M. E. Ortiz, S. Bollo, and J. A. Squella. Electrochemical generation and reactivity of free radicals redox intermediates from ortho- and meta-nitro substituted 1,4-dihydropyridines. Chemico-Biological Interactions 106:1-14 (1997).
17. P. Gonzalez. Nimesulide: possible formation of free radicals? Comparative study with nitrofurantoin. Licentiate thesis University of Chile (1996).