Increased cerebral extracellular adenosine and decreased PGE2 during ethanol-induced inhibition of FBM

Journal of Applied Physiology

Volumn 86, Issue 4, 1999, Pages 1410-1420

  Watson, Carole S ^a   White, Susan E ^a   Homan, Jacobus H ^a   Kimura, Karen A ^b   Brien, James F ^b   Fraher, Laurence ^a   Challis, John R G ^c   Bocking, Alan D ^a,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

Electrocortical activity; Eye movements; Fetal behavior; Fetal breathing movements; Microdialysis; Prostaglandin E2

Indexed keywords

ADENOSINE; ALCOHOL; GLUCOSE; LACTIC ACID; PROSTAGLANDIN E2;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTERIAL GAS; ARTICLE; BLOOD PH; BRAIN LEVEL; EXTRACELLULAR FLUID; EYE MOVEMENT; FEMALE; FETUS; FETUS BREATHING; MICRODIALYSIS; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RESPIRATION DEPRESSION; SHEEP;

EID: 0032906211     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.4.1410     Document Type: Article

References (49)

1. Abel, E. L. An update on the incidence of FAS: FAS is not an equal opportunity birth defect. Neurotoxicol. Teratol. 17: 437-443, 1995.
2. Avital, A., A. H. Jansen, D. S. Sitar, and V. Chernick. Influence of prolonged adenosine receptor blockade on fetal sleep and breathing patterns. Respir. Physiol. 91: 227-236, 1993.
3. Ballarín, M., B. B. Fredholm, S. Ambrosio, and N. Mahy. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta Physiol. Scand. 142: 97-103, 1991.
4. Benveniste, H. Brain microdialysis. J. Neurochem. 52: 1667-1679, 1989.
5. Benveniste, H., and N. H. Diemer. Cellular reactions to implantation of a microdialysis tube in the rat hippocampus. Acta Neuropathol. (Berl.) 74: 234-238, 1987.
6. Benveniste, H., J. Drejer, A. Schousboe, and N. H. Diemer. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43: 1369-1374, 1984.
7. Benveniste, H., J. Drejer, A. Schousboe, and N. H. Diemer. Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat. J. Neurochem. 49: 729-734, 1987.
8. Bissonnette, J. M., A. R. Hohimer, and S. J. Knopp. The effect of centrally administered adenosine on fetal breathing movements. Respir. Physiol. 84: 273-285, 1991.
9. 2, and myometrial activity. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R1297-R1301, 1994.
10. Bocking, A. D., R. Gagnon, K. M. Milne, and S. E. White. Behavioral activity during prolonged hypoxemia in fetal sheep. J. Appl. Physiol. 65: 2420-2426, 1988.
11. 2 during ethanol infusion. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R640-R645, 1993.
12. Brien, J. F., D. W. Clarke, B. Richardson, and J. Patrick. Disposition of ethanol in maternal blood, fetal blood and amniotic fluid of third trimester pregnant ewes. Obstet. Gynecol. 152: 583-590, 1985.
13. Carmichael, F. J., Y. Israel, M. Crawford, K. Minhas, V. Saldivia, S. Sandrin, P. Campisi, and H. Orrego. Central nervous system effects of acetate: contribution to the central effects of ethanol. J. Pharmacol. Exp. Ther. 259: 403-408, 1991.
14. Clark, M., and M. S. Dar. Effect of acute ethanol on release of endogenous adenosine from rat cerebellar synaptosomes. J. Neurochem. 52: 1859-1865, 1989.
15. Dar, M. S. Central adenosinergic system involvement in ethanol-induced motor incoordination in mice. J. Pharmacol. Exp. Ther. 255: 1202-1209, 1990.
16. Dar, M. S., S. J. Mustafa, and W. R. Wooles. Possible role of adenosine in the CNS effects of ethanol. Life Sci. 33: 1363-1374, 1983.
17. Dawes, G. S., H. E. Fox, B. M. Leduc, G. C. Liggins, and R. T. Richards. Respiratory movements and rapid eye movement sleep in the foetal lamb. J. Physiol. (Lond.) 220: 119-143, 1972.
18. Falconer, J. The effect of maternal ethanol infusion on placental blood flow and fetal glucose metabolism in sheep. Alcohol Alcohol. 25: 413-416, 1990.
19. Fox, H. E., M. Steinbrecher, D. Pessel, J. Inglis, L. Medvid, and E. Angel. Maternal ethanol ingestion and the occurrence of human fetal breathing movements. Am. J. Obstet. Gynecol. 132: 354-358, 1978.
20. Gibb, W., S. G. Matthews, and J. R. G. Challis. Localization and developmental changes in prostaglandin H synthase (PGHS) and PGHS mRNA in ovine placenta throughout gestation. Biol. Reprod. 54: 654-659, 1996.
21. Hartwick, R. A., S. P. Assenza, and P. R. Brown. Identification and quantification of nucleosides, bases and other UV-absorbing compounds in serum, using reversed-phase high-performance liquid chromatography. I. Chromatographic methodology. J. Chromatogr. 186: 647-658, 1979.
22. 2 in cerebrospinal fluid of fetal and newborn sheep: central versus peripheral source. Biol. Neonate 66: 339-351, 1994.
23. Kitterman, J. A., G. C. Liggins, J. E. Fewell, and W. H. Tooley. Inhibition of breathing movements in fetal sheep by prostaglandins. J. Appl. Physiol. 54: 687-692, 1983.
24. Koos, B. J., and W. Doany. Role of plasma adenosine in breathing responses to hypoxia in fetal sheep. J. Dev. Physiol. (Eynsham) 16: 81-85, 1991.
25. Koos, B. J., L. Kruger, and T. F. Murray. Source of extracellular brain adenosine during hypoxia in fetal sheep. Brain Res. 778: 439-442, 1997.
26. Koos, B. J., B. A. Mason, O. Punla, and A. M. Adinolfi. Hypoxic inhibition of breathing in fetal sheep: relationship to brain adenosine concentrations. J. Appl. Physiol. 77: 2734-2739, 1994.
27. Koos, B. J., and K. Matsuda. Fetal breathing, sleep state, and cardiovascular responses to adenosine in sheep. J. Appl. Physiol. 68: 489-495, 1990.
28. McLeod, W., J. Brien, C. Loomis, L. Carmichael, C. Probert, and J. Patrick. Effect of maternal ethanol ingestion on fetal breathing movements, gross body movements, and heart rate at 37 to 40 weeks' gestational age. Am. J. Obstet. Gynecol. 145: 251-257, 1983.
29. Moss, I. R., and J. G. Inman. Neurochemicals and respiratory control during development. J. Appl. Physiol. 67: 1-13, 1989.
30. Nagy, L. E., I. Diamond, D. J. Casso, C. Franklin, and A. S. Gordon. Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter. J. Biol. Chem. 265: 1946-1951, 1990.
31. Olson, D. M., S. J. Lye, K. Skinner, and J. R. G. Challis. Early changes in prostaglandin concentrations in ovine maternal and fetal plasma, aminiotic fluid and from dispersed cells of intrauterine tissues before the onset of ACTH-induced preterm labour. J. Reprod. Fertil. 71: 45-55, 1984.
32. Pace-Asciak, C. R., and G. Rangaraj. Prostaglandin biosynthesis and catabolism in the developing sheep brain. J. Biol. Chem. 251: 3381-3385, 1976.
33. Pappius, H. M., and L. S. Wolfe. Effects of indomethacin and ibuprofen on cerebral metabolism and blood flow in traumatized brain. J. Cereb. Blood Flow Metab. 3. 448-459, 1983.
34. Patrick, J., B. Richardson, G. Hasen, D. Clarke, M. Wlodek, J. Bousquet, and J. Brien. Effects of maternal ethanol infusion on fetal cardiovascular and brain activity in lambs. Am. J. Obstet. Gynecol. 151: 859-867, 1985.
35. Penning, D. H., D. H. Chestnut, F. Dexter, J. Hardy, D. Poduska, and B. Atkins. Glutamate release from the ovine fetal brain during maternal hemorrhage: a study using chronic in utero cerebral microdialysis. Anesthesiology 82: 521-530, 1995.
36. 1 receptor activation in ethanol-induced inhibition of stimulated glutamate release in the hippocampus of the fetal and adult guinea pig. Alcohol 12: 151-157, 1995.
37. Reynolds, J. D., D. H. Penning, K. A. Kimura, F. Dexter, J. L. Henderson, B. Atkins, D. Poduska, and J. F. Brien. Ethanol-induced changes in prostaglandin E concentration in the intact cerebral cortex of preterm and near-term fetal sheep. Alcohol. Clin. Exp. Res. 21: 997-1004, 1997.
38. Richardson, B. S., J. E. Patrick, J. Bousquet, J. Homan, and J. F. Brien. Cerebral metabolism in fetal lamb after maternal infusion of ethanol. Am. J. Physiol. 249 (Regulatory Integrative Comp. Physiol. 18): R505-R509, 1985.
39. Sinervo, K. R., G. N. Smith, A. D. Bocking, J. Patrick, and J. F. Brien. Effect of ethanol on the release of prostaglandins from ovine fetal brain stem during gestation. Alcohol. Clin. Exp. Res. 16: 443-448, 1992.
40. Smith, G. N., J. F. Brien, J. Homan, L. Carmichael, and J. Patrick. Indomethacin antagonizes the ethanol-induced suppression of breathing activity but not the suppression of brain activity in the near-term fetal sheep. J. Dev. Physiol. (Eynsham) 12: 69-75, 1989.
41. 2 concentrations and fetal breathing movements. J. Dev. Physiol. (Eynsham) 14: 23-28, 1990.
42. Steenaart, N. A. E., D. W. Clarke, and J. F. Brien. Gas-liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetaldehyde formation. J. Pharmacol. Methods 14: 199-212, 1985.
43. Trenkle, A. Endocrine regulation of energy metabolism in ruminants. Federation Proc. 40: 2536-2541, 1981.
44. Vega, W. A., B. Kolody, J. Hwang, and A. Noble. Prevalence and magnitude of perinatal substance exposures in California. N. Engl. J. Med. 329: 850-854, 1993.
45. Watson, C. S., S. E. White, J. Homan, S. Abdollah, J. F. Brien, J. R. G. Challis, and A. D. Bocking. Fetal breathing is not inhibited by ethanol exposure during prolonged reduced uterine blood flow. Can. J. Physiol. Pharmacol. 74: 1016-1024, 1996.
46. 2 inhibition of fetal breathing movements is not sustained during prolonged reduced uterine blood flow in sheep. Can. J. Physiol. Pharmacol. 76: 1-9, 1998.
47. Williams, H. E. Alcoholic hypoglycemia and ketoacidosis. Med. Clin. North Am. 68: 33-38, 1984.
48. Wimsatt, J., P. W. Nathanielsz, and J. Sirois. Induction of prostaglandin endoperoxide synthase isoform-2 in ovine cotyledonary tissues during late-gestation. Endocrinology 133: 1068-1073, 1993.
49. Yergey, J. A., and M. P. Heyes. Brain eicosanoid formation following acute penetration injury as studied by in vivo microdialysis. J. Cereb. Blood Flow Metab. 10: 143-146, 1990.