Fertilization antigen-1 removes antisperm autoantibodies from spermatozoa of infertile men and results in increased rates of acrosome reaction

Fertility and Sterility

Volumn 71, Issue 2, 1999, Pages 256-260

  Menge, Alan C ^a   Christman, Gregory M ^a   Ohl, Dana A ^b   Naz, Rajesh K ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Acrosome reaction; Antisperm autoantibodies; FA 1; Male infertility; Sperm antigen

Indexed keywords

AUTOANTIBODY; FERTILIZATION ANTIGEN 1; SPERM ANTIBODY; SPERM ANTIGEN; UNCLASSIFIED DRUG;

ACROSOME; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOADSORPTION; INTRACYTOPLASMIC SPERM INJECTION; MALE; MALE INFERTILITY; PRIORITY JOURNAL; SEMEN ANALYSIS; SPERMATOZOON MOTILITY;

ACROSOME REACTION; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; AUTOANTIBODIES; CALCIMYCIN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOSORBENT TECHNIQUES; INFERTILITY, MALE; IONOPHORES; MALE; PROSPECTIVE STUDIES; SPERMATOZOA;

EID: 0032906164     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(98)00468-3     Document Type: Article

References (29)

1. Naz R.K., Menge A.C. Antisperm antibodies origin, regulation, and sperm reactivity in human infertility . Fertil Steril. 61:1994;1001-1013.
2. Tasdemir I., Tasdemir M., Fukuda J., Kodama H., Matsui T., Tanaka T. Sperm immobilizing antibodies in infertile male sera decrease the acrosome reaction a possible mechanism for immunologic infertility . J Assist Reprod Genet. 13:1996;413-416.
3. Shibahara H., Shigeta M., Inoue M., Hasegawa A., Koyama K., Alexander N.J., et al. Diversity of the blocking effects of antisperm antibodies on fertilization in human and mouse. Hum Reprod. 11:1996;2595-2599.
4. Margalloth E.J., Sauter E., Bronson R.A., Rosenfeld D.L., Scholl G.M., Cooper G.W. Intrauterine insemination as treatment for antisperm antibodies in the female. Fertil Steril. 50:1988;441-446.
5. Acosta A.A., Oehninger S., Morshedi M., Swanson R.J., Scott R., Irianni F. Assisted reproduction in the diagnosis and treatment of male factor. Obstet Gynecol Surv. 44:1989;1-18.
6. Nagy Z.P., Verheyen G., Liu J., Joris H., Janssenswillen C., Wisanto A., et al. Results of 55 intracytoplasmic sperm injection cycles in the treatment of male-immunological infertility. Hum Reprod. 10:1995;1775-1780.
7. Clarke G.N., Lopata A., McBain J.C., Baker H.W.G., Johnston W.I.H. Effect of sperm antibodies in males on human in vitro fertilization (IVF). Am J Reprod Immunol. 8:1985;62-66.
8. Naz R.K. Involvement of fertilization antigen (FA-1) in involuntary immunoinfertility in humans. J Clin Invest. 80:1987;1375-1383.
9. Naz R.K., Ahmad K., Menge A.C. Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies. J Clin Invest. 92:1993;2331-2338.
10. Bronson R.A., Cooper G.W., Margalioth E.J., Naz R.K., Hamilton M.S. The detection in human sera of antisperm antibodies reactive with FA-1, and evolutionarily conserved antigen, and with murine spermatozoa. Fertil Steril. 52:1989;457-462.
11. Naz R.K., Brazil C., Overstreet J.W. Effects of antibodies to sperm surface fertilization antigen-1 on human sperm-zona pellucida interaction. Fertil Steril. 57:1992;1304-1310.
12. Kaplan P., Naz R.K. The fertilization antigen-1 does not have proteolytic/acrosin activity, but its monoclonal antibody inhibits human sperm capacitation and acrosome reaction. Fertil Steril. 58:1992;396-402.
13. Kadam A.L., Fateh M., Naz R.K. Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida FA-1 antigen may be a sperm receptor for zona pellucida in humans . J Reprod Immunol. 29:1995;19-30.
14. Naz R.K., Sacco A.G., Yurewicz E.C. Human spermatozoal FA-1 binds with ZP3 of porcine zona pellucida. J Reprod Immunol. 20:1991;43-58.
15. Naz R.K., Alexander N.J., Isahakia M., Hamilton M.S. Monoclonal antibodies to a human sperm cell membrane glycoprotein that inhibits fertilization. Science. 225:1984;342-344.
16. Naz R.K., Phillips T.M., Rosenblum B.B. The characterization of fertilization antigen 1 for the development of contraceptive vaccine. Proc Natl Acad Sci USA. 83:1986;5713-5717.
17. Zhu X., Naz R. Fertilization antigen-1 cDNA cloning, testis-specific expression, and immunocontraceptive effects . Proc Natl Acad Sci USA. 94:1997;4704-4707.
18. Aitken R.J., Buckingham D.W., Fang H.G. Analysis of the responses of human spermatozoa to A23187 employing a novel technique for assessing the acrosome reaction. J Androl. 14:1993;132-141.
19. Haas G.G., D'Cruz O., Denum B.M. Effect of repeated washing on sperm-bound immunoglobulin G. J Androl. 9:1988;190-196.
20. Hinting A., Vermeulen L., Goethals I., Dhont M., Comhaire F. Effect of different procedures of semen preparation on antibody-coated spermatozoa and immunological infertility. Fertil Steril. 52:1989;1022-1026.
21. Bronson R.A., Cooper G.W., Rosenfeld D.L., Gilbert J.V., Plaut A.G. The effect of an IgA1 protease on immunoglobulins bound to the sperm surface and sperm cervical mucus penetrating ability. Fertil Steril. 47:1987;985-991.
22. Kutteh W.H., Killian M., Ermel L.D., Byrd E.W., Mestecky J. Antisperm antibodies (ASAs) in infertile males subclass distribution of IgA antibodies and the effect of an IgA1 protease on sperm-bound antibodies . Am J Reprod Immunol. 31:1994;77-83.
23. Haas G.G., Manganiello P. A double-blind, placebo-controlled study of the use of methylprednisolone in infertile men with sperm-associated immunoglobulins. Fertil Steril. 47:1987;295-301.
24. Grigoriou O., Konidaris S., Antonaki V., Papadias C., Antoniou G., Gargaropoulos A. Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies. Eur J Obstet Gynecol Reprod Biol. 65:1996;227-230.
25. Mahony M.C., Blackmore P.F., Bronson R.A., Alexander N.J. Inhibition of human sperm-zona pellucida tight binding in the presence of antisperm antibody positive polyclonal patient sera. J Reprod Immunol. 19:1991;287-301.
26. Bronson R.A., Cooper G.W., Rosenfeld D.L. Sperm-specific isoantibodies and autoantibodies inhibit the binding of human sperm to the human zona pellucida. Fertil Steril. 38:1982;724-729.
27. Francavilla F., Romano R., Santucci R., Marrone V., Properzi G., Ruvolo G. Interference of antisperm antibodies with the induction of the acrosome reaction by the zona pellucida (ZP) and its relationship with the inhibition of ZP binding. Fertil Steril. 67:1997;1128-1133.
28. Wolf J.P., De Almeida M., Ducot B., Rodrigues D., Jouannet P. High levels of sperm-associated antibodies impair human sperm oolemma interaction after subzonal insemination. Fertil Steril. 63:1995;584-590.
29. Zouari R., De Almeida M., Feneux D. Effect of sperm-associated antibodies on the dynamics of sperm movement and on the acrosome reaction of human spermatozoa. J Reprod Immunol. 22:1992;59-72.