-
1
-
-
0002855914
-
Towards better chelation therapy: Current concepts and research strategy
-
R. J. Bergeron and G. M. Brittenham (eds.)
-
1. H. P. Schnebli, I. Hassan, K. O. Hamilton, S. Lynch, Y. Jin, H. P. Nick, H. H. Peter, U. Junker-Walker, R. Ziel, S. C. Khanna, R. Dean, and R. J. Bergeron. Towards better chelation therapy: current concepts and research strategy, in The Development of Iron Chelators for Clinical Use, R. J. Bergeron and G. M. Brittenham (eds.), 1994, p. 131.
-
(1994)
The Development of Iron Chelators for Clinical Use
, pp. 131
-
-
Schnebli, H.P.1
Hassan, I.2
Hamilton, K.O.3
Lynch, S.4
Jin, Y.5
Nick, H.P.6
Peter, H.H.7
Junker-Walker, U.8
Ziel, R.9
Khanna, S.C.10
Dean, R.11
Bergeron, R.J.12
-
2
-
-
0031457203
-
A risk-benefit of iron-chelation therapy
-
2. J. B. Porter. A risk-benefit of iron-chelation therapy. Drug Saf. 17:407-421 (1997).
-
(1997)
Drug Saf.
, vol.17
, pp. 407-421
-
-
Porter, J.B.1
-
5
-
-
0023700267
-
Selection of hydroxypyridin-4-ones for the treatment of Iron Overload using in vitro and in vivo models
-
5. E. R. Huehns, J. B. Porter, and R. C. Hider. Selection of Hydroxypyridin-4-ones for the treatment of Iron Overload using in vitro and in vivo models. Haemoglobin 12:593-600 (1988).
-
(1988)
Haemoglobin
, vol.12
, pp. 593-600
-
-
Huehns, E.R.1
Porter, J.B.2
Hider, R.C.3
-
6
-
-
0023522037
-
In vivo evaluation of hydroxypyridone iron chelators in a mouse model
-
6. M. Gyparaki, J. B. Porter, S. Hirani, M. Streater, R. C. Hider, and E. R. Huehns. In vivo evaluation of Hydroxypyridone Iron Chelators in a Mouse Model. Acta Haematol (Basel) 78:217-221 (1987).
-
(1987)
Acta Haematol (Basel)
, vol.78
, pp. 217-221
-
-
Gyparaki, M.1
Porter, J.B.2
Hirani, S.3
Streater, M.4
Hider, R.C.5
Huehns, E.R.6
-
7
-
-
0023099826
-
Iron chelation studies using desferrioxamine and the potential oral iron chelator, 1,2,-dimethyl-3-hydroxypyrid-4-one, in normal and iron overloaded rats
-
7. G. J. Kontoghiorghes, L. Sheppard, A. V. Hoffbrand, J. Charalamous, J. Tiperpae, and M. J. Pippard. Iron Chelation Studies using Desferrioxamine and the Potential Oral Iron Chelator, 1,2,-Dimethyl-3-hydroxypyrid-4-one, in Normal and Iron Overloaded Rats. J. Clin. Pathol. 40:404-408 (1987).
-
(1987)
J. Clin. Pathol.
, vol.40
, pp. 404-408
-
-
Kontoghiorghes, G.J.1
Sheppard, L.2
Hoffbrand, A.V.3
Charalamous, J.4
Tiperpae, J.5
Pippard, M.J.6
-
8
-
-
0025838375
-
Comparison of the subacute toxicity and efficacy of 3-hydroxypyridin-4-one iron chelators in overloaded and nonoverloaded mice
-
8. J. B. Porter, K. P. Hoyes, R. D. Abeysinghe, P. N. Brooks, E. R. Huehns, and R. C. Hider. Comparison of the Subacute Toxicity and Efficacy of 3-Hydroxypyridin-4-one Iron Chelators in Overloaded and Nonoverloaded Mice. Blood 78:2727-2734 (1991).
-
(1991)
Blood
, vol.78
, pp. 2727-2734
-
-
Porter, J.B.1
Hoyes, K.P.2
Abeysinghe, R.D.3
Brooks, P.N.4
Huehns, E.R.5
Hider, R.C.6
-
9
-
-
0023214937
-
1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload
-
9. G. J. Kontoghiorghes, M. A. Aldouri, L. Sheppard, and A. V. Hoffbrand. 1,2-Dimethyl-3-hydroxypyrid-4-one, an Orally Active Chelator for Treatment of Iron Overload. Lancet 1294 (1987).
-
(1987)
Lancet
, vol.1294
-
-
Kontoghiorghes, G.J.1
Aldouri, M.A.2
Sheppard, L.3
Hoffbrand, A.V.4
-
10
-
-
0345562642
-
Effective iron chelation with L1 in patients with thalassaemia major. Iron balance and dose response studies
-
10. N. F. Olivieri, G. Koren, C. Hermann, D. Chung, R. McClelland, M. Freedman, P. St. Louis, and D. Templeton. Effective Iron Chelation with L1 in Patients with Thalassaemia Major. Iron Balance and Dose Response Studies. Blood 74:51a (1989).
-
(1989)
Blood
, vol.74
-
-
Olivieri, N.F.1
Koren, G.2
Hermann, C.3
Chung, D.4
McClelland, R.5
Freedman, M.6
St. Louis, P.7
Templeton, D.8
-
11
-
-
0029079707
-
Results of long-term deferiprone (L1) therapy: A report by the international study group on oral iron chelators
-
11. F. N. Al-Refaie, C. Hershko, A. V. Hoffbrand, M. Kosaryan, N. F. Olivieri, P. Tondury, and B. Wonke. Results of Long-Term Deferiprone (L1) Therapy: A Report by the International Study Group on Oral Iron Chelators. Br. J. Haematol. 91:224-229 (1995).
-
(1995)
Br. J. Haematol.
, vol.91
, pp. 224-229
-
-
Al-Refaie, F.N.1
Hershko, C.2
Hoffbrand, A.V.3
Kosaryan, M.4
Olivieri, N.F.5
Tondury, P.6
Wonke, B.7
-
13
-
-
0002614944
-
Stabilities of the iron(III) chelates of 1,2-dimethyl-3-hydroxy-4-pyridinone and related ligands
-
13. R. J. Motekaitis and A. E. Martell. Stabilities of the Iron(III) Chelates of 1,2-Dimethyl-3-hydroxy-4-pyridinone and Related Ligands. Inorg. Chim. Acta. 183:71-80 (1991).
-
(1991)
Inorg. Chim. Acta.
, vol.183
, pp. 71-80
-
-
Motekaitis, R.J.1
Martell, A.E.2
-
14
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
14. P. Artusson and J. Karlsson. Correlation between Oral Drug Absorption in Humans and Apparent Drug Permeability Coefficients in Human Intestinal Epithelial (Caco-2) Cells. Biochem. Biophys. Res. Commun. 175:880-885 (1991).
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.175
, pp. 880-885
-
-
Artusson, P.1
Karlsson, J.2
-
15
-
-
0023715382
-
Estimating human fraction absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
-
15. G. L. Amidon, P. J. Sinko, and D. Fleisher. Estimating Human Fraction Absorbed: a Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-mediated compounds. Pharm. Res. 5:651-654 (1988).
-
(1988)
Pharm. Res.
, vol.5
, pp. 651-654
-
-
Amidon, G.L.1
Sinko, P.J.2
Fleisher, D.3
-
16
-
-
0028948839
-
A theoretical basis for a Biopharmaceutic Drug Classification: The correlation of in vitro Drug Product Dissolution and in vivo bioavailability
-
16. G. L. Amidon, H. Lennernäs, V. P. Shah, and J. R. Crison. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in vitro Drug Product Dissolution and in vivo Bioavailability. Pharm. Res. 12:413-420 (1995).
-
(1995)
Pharm. Res.
, vol.12
, pp. 413-420
-
-
Amidon, G.L.1
Lennernäs, H.2
Shah, V.P.3
Crison, J.R.4
-
17
-
-
0026603949
-
Proline uptake by Monolayers of Human Intestinal Absorptive (Caco-2) Cells in vitro
-
17. P. L. Nicklin, W. J. Irwin, I. F. Hassan, and M. Mackay. Proline Uptake by Monolayers of Human Intestinal Absorptive (Caco-2) Cells in vitro. Biochim. Biophys. Acta. 1104:283-292 (1992).
-
(1992)
Biochim. Biophys. Acta.
, vol.1104
, pp. 283-292
-
-
Nicklin, P.L.1
Irwin, W.J.2
Hassan, I.F.3
Mackay, M.4
-
19
-
-
0023598658
-
Ionisation constants by curve fitting: Determination of partition and distribution coefficients of acids and bases and their ions
-
19. F. H. Clarke and N. M. Cahoon. Ionisation Constants by Curve Fitting: Determination of Partition and Distribution Coefficients of Acids and Bases and their Ions. J. Pharm. Sci. 76:611-620 (1987).
-
(1987)
J. Pharm. Sci.
, vol.76
, pp. 611-620
-
-
Clarke, F.H.1
Cahoon, N.M.2
-
20
-
-
0027245634
-
pH-Metric logP. 2. Refinement of partition coefficients and ionisation constants of multiprotic substances
-
20. A. Avdeef. pH-Metric logP. 2. Refinement of Partition Coefficients and Ionisation Constants of Multiprotic Substances. J. Pharm. Sci. 82:183-190 (1993).
-
(1993)
J. Pharm. Sci.
, vol.82
, pp. 183-190
-
-
Avdeef, A.1
-
21
-
-
0027071736
-
pH-Metric logP. 1. Difference plots for determining ion-pair octanol-water partition coefficients of multiprotic substances
-
21. A. Avdeef. pH-Metric logP. 1. Difference Plots for Determining Ion-Pair Octanol-Water Partition Coefficients of Multiprotic Substances. Quant. Struct.-Act. Relat. 11:510-517 (1992).
-
(1992)
Quant. Struct.-Act. Relat.
, vol.11
, pp. 510-517
-
-
Avdeef, A.1
-
22
-
-
0025835284
-
Evaluation of desferrithiocin and its synthetic analogues as orally effective iron chelators
-
22. R. J. Bergeron, J. Wiegand, J. B. Dionis, M. Egli-Karmakka, J. Frei, A. Huxley-Tencer, and H. H. Peter. Evaluation of Desferrithiocin and its Synthetic Analogues as Orally Effective Iron Chelators. J. Med. Chem. 34:2072-2078 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2072-2078
-
-
Bergeron, R.J.1
Wiegand, J.2
Dionis, J.B.3
Egli-Karmakka, M.4
Frei, J.5
Huxley-Tencer, A.6
Peter, H.H.7
-
24
-
-
0025559639
-
A comparative evaluation of iron clearance models
-
24. R. J. Bergeron, R. R. Streiff, J. Wiegand, J. R. T. Vinson, G. Luchetta, K. M. Evans, H. H. Peter, and H. B. Jenny. A Comparative Evaluation of Iron Clearance Models. Ann. NY Acad. Sci. 612:378-393 (1990).
-
(1990)
Ann. NY Acad. Sci.
, vol.612
, pp. 378-393
-
-
Bergeron, R.J.1
Streiff, R.R.2
Wiegand, J.3
Vinson, J.R.T.4
Luchetta, G.5
Evans, K.M.6
Peter, H.H.7
Jenny, H.B.8
-
25
-
-
0019124619
-
A convective mass transfer model for determining intestinal wall permeabilities: Laminar flow in a circular tube
-
25. R. L. Elliott, G. L. Amidon, and E. N. Lightfoot. A Convective Mass Transfer Model for Determining Intestinal Wall Permeabilities: laminar Flow in a Circular Tube. J. Theor. Biol. 87:757-771 (1980).
-
(1980)
J. Theor. Biol.
, vol.87
, pp. 757-771
-
-
Elliott, R.L.1
Amidon, G.L.2
Lightfoot, E.N.3
-
26
-
-
0004108918
-
-
McGraw-Hill, New York
-
26. R. C. Reid, J. M. Prausnitz, and T. K. Sherwood, in The Properties of Liquids and Gases, McGraw-Hill, New York, 1977, pp. 57-59.
-
(1977)
The Properties of Liquids and Gases
, pp. 57-59
-
-
Reid, R.C.1
Prausnitz, J.M.2
Sherwood, T.K.3
-
27
-
-
0000773829
-
Intestinal absorption mechanism of three angiolensin-converting enzyme inhibitors: Quinapril, Benazepril and CGS 16617
-
27. S. Yee and G. L. Amidon. Intestinal Absorption Mechanism of Three Angiolensin-Converting Enzyme Inhibitors: Quinapril, Benazepril and CGS 16617. Pharm. Res. 7:S155 (1990).
-
(1990)
Pharm. Res.
, vol.7
-
-
Yee, S.1
Amidon, G.L.2
-
28
-
-
13344277282
-
Azole endothelin antagonists. 3. Using A logP as a tool to improve absorption
-
28. T. W. von Geldern, D. J. Hoffman, J. A. Kester, H. N. Nellans, B. D. Dayton, S. V. Calzadilla, K. C. Marsh, L. Hernandez, W. Chiou, D. B. Dixon, J. R. Wu-Wong, and T. J. Opgenorth. Azole Endothelin Antagonists. 3. Using A logP as a Tool to Improve Absorption. J. Med. Chem. 39:982-991 (1996).
-
(1996)
J. Med. Chem.
, vol.39
, pp. 982-991
-
-
Von Geldern, T.W.1
Hoffman, D.J.2
Kester, J.A.3
Nellans, H.N.4
Dayton, B.D.5
Calzadilla, S.V.6
Marsh, K.C.7
Hernandez, L.8
Chiou, W.9
Dixon, D.B.10
Wu-Wong, J.R.11
Opgenorth, T.J.12
-
29
-
-
0002177778
-
Biopharmaceutical considerations in drug formulation design and evaluation
-
29. S. A. Kaplan. Biopharmaceutical Considerations in Drug Formulation Design and Evaluation. Drug Metab. Rev. 1:15-33 (1972).
-
(1972)
Drug Metab. Rev.
, vol.1
, pp. 15-33
-
-
Kaplan, S.A.1
-
30
-
-
0024405310
-
Preformulation study of etoposide: Identification of physicochemical characteristics responsible for the low and erratic oral bioavailability of etoposide
-
30. J. C. Shah, J. R. Chen, and D. Chow. Preformulation Study of Etoposide: Identification of Physicochemical Characteristics Responsible for the Low and Erratic Oral Bioavailability of Etoposide. Pharm. Res. 6:408-412 (1989).
-
(1989)
Pharm. Res.
, vol.6
, pp. 408-412
-
-
Shah, J.C.1
Chen, J.R.2
Chow, D.3
-
31
-
-
0020035215
-
Perspectives in iron metabolism
-
31. C. A. Finch and H. Hubers. Perspectives in Iron Metabolism. New Engl. J. Med. 306:1520 (1982).
-
(1982)
New Engl. J. Med.
, vol.306
, pp. 1520
-
-
Finch, C.A.1
Hubers, H.2
|