The Spo0A sof mutations reveal regions of the regulatory domain that interact with a sensor kinase and RNA polymerase

Molecular Microbiology

Volumn 31, Issue 2, 1999, Pages 597-607

  Cervin, Marguerite A ^a   Spiegelman, George B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; PROTEIN KINASE; RNA POLYMERASE;

ARTICLE; BACILLUS SUBTILIS; GENE DELETION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPOROGENESIS; SUPPRESSOR GENE; TRANSCRIPTION INITIATION;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; DNA-DIRECTED RNA POLYMERASES; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN KINASES; SIGMA FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0032904672     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01200.x     Document Type: Article

References (48)

1. Asayama, M., Yamamoto, A., and Kobayashi, Y. (1995) Dimer form of phosphorylated Spo0A, a transcriptional regulator, stimulates the spo0F transcription at the initiation of sporulation in Bacillus subtilis. J Mol Biol 250: 11-23
2. Baikalov, I., Schroder, I., Kaczor-Grzeskowiak, M., Grzeskowiak, K., Gunsalus, R.P., and Dickerson, R.E. (1996) Structure of the Escherichia coli response regulator NarL. Biochemistry 35: 11053-11061
3. Baldus, J.M., Green, B.D., Youngman, P., and Moran, Jr, C.P. (1994) Phosphorylation of Bacillus subtilis transcription from the spoIIG promoter by enhancing binding to weak 0A boxes. J Bacteriol 176: 296-306
4. Baldus, J.M., Buckner, C.M., and Moran, Jr, C.P. (1995) Evidence that the transcriptional activator Spo0A interacts with two sigma factors in Bacillus subtilis. Mol Microbiol 17: 281-290
5. Bird, T.H., Grimsley, J.K., Hoch, J.A., and Spiegelman, G.B. (1993) Phosphorylation of Spo0A activates its stimulation of in vitro transcription from the Bacillus subtilis spoIIG operon. Mol Microbiol 9: 741-749
6. Bird, T.H., Grimsley, J.K., Hoch, J.A., and Spiegelman, G.B. (1996) The Bacillus subtilis response regulator Spo0A stimulates transcription of the spoIIG operon through modification of RNA polymerase promoter complexes. J Mol Biol 256: 436-448
7. Brissette, R.E., Tsung, K., and Inouye, M. (1992) Mutations in a central highly conserved non-DNA-binding region of OmpR, an Escherichia coli transcriptional activator, influence its DNA-binding ability. J Bacteriol 174: 4907-4912
8. Buckner, C.M., Schyns, G., and Moran, C.P. Jr (1998) A region in the Bacillus subtilis transcription factor Spo0A that is important for spoIIG promoter activation. J Bacteriol 180: 3578-3583
9. Burbulys, D., Trach, K.A., and Hoch, J.A. (1991) Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 64: 545-552
10. Chen, P., and Reitzer, L.J. (1995) Active contribution of two domains to cooperative DNA binding of the enhancer-binding protein nitrogen regulator I (NtrC) of Escherichia coli: stimulation by phosphorylation and the binding of ATP. J Bacteriol 177: 2490-2496
11. Dobinson, K.D., and Spiegelman, G.B. (1987) Effect of δ subunit on Bacillus subtilis RNA polymerase RNA synthesis at two bacteriophage φ29 promoters. Biochemistry 26: 8206-8213
12. Feher, V.A., Zapf, J.W., Hoch, J.A., Whitely, J.M., McIntosh, L.P., Rance, M., et al. (1997) High-resolution NMR structure and backbone dynamics of the Bacillus subtilis response regulator, Spo0F: implications for phosphorylation and molecular recognition. Biochemistry 36: 10015-10025
13. Feher, V.A., Tzeng, Y.L., Hoch, J.A., and Cavanagh, J. (1998) Identification of communication networks in Spo0F: a model for phosphorylation-induced conformational change and implications for activation of multiple domain bacterial response regulators. FEBS Lett 425: 1-6
14. Ferrari, F.A., Trach, K., LeCoq, D., Spence, J., Ferrari, E., and Hoch, J.A. (1985) Characterization of the spo0A locus and its deduced product. Proc Natl Acad Sci USA 82: 2647-2651
15. Green, B.D., Bramucci, M.G., and Youngman, P. (1991) Mutant forms of Spo0A that affect sporulation initiation: a general model for phosphorylation mediated activation of bacterial signal transduction proteins. Semin Dev Biol 2: 21-29
16. Greene, E.A., and Spiegelman, G.B. (1996) The Spo0A protein of Bacillus subtilis inhibits transcription of the abrB gene without preventing binding of the polymerase to the promoter. J Biol Chem 271: 11455-11461
17. Grimsley, J.K., Tjalkens, R.B., Strauch, M.A., Bird, T.H., Spiegelman, G.B., Hostomsky, Z., et al. (1994) Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis. J Biol Chem 269: 16977-16982
18. Hatt, J.K., and Youngman, P. (1998) Spo0A mutants of Bacillus subtilis with sigma factor-specific defects in transcription activation. J Bacteriol 180: 3584-3591
19. Hoch, J.A. (1991) Genetic analysis in Bacillus subtilis. Methods Enzymol 204: 305-320
20. Hoch, J.A. (1993) Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis. Annu Rev Microbiol 74: 441-466
21. Hoch, J.A. (1995) Control of cellular development in sporulating bacteria by the phosphorelay two-component signal transduction system. In Two-Component Signal Transduction. Hoch, J.A., and Silhavy, T.J. (eds). Washington, DC: American Society for Microbiology Press, pp. 129-144
22. Ireton, K., Rudner, D.Z., Siranosian, K.J., and Grossman, A.D. (1993) Integration of multiple developmental signals in Bacillus subtilis through the Spo0A transcription factor. Genes Dev 7: 283-294
23. Kobayashi, K., Shoji, K., Shimizu, T., Nakano, K., Sato, T., and Kobayashi, Y. (1995) Analysis of a suppressor mutation ssb (kinC) of sur0B20 (spo0A) mutation in Bacillus subtilis reveals that kinC encodes a histidine protein kinase. J Bacteriol 177: 176-182
24. LeDeaux, J.R., and Grossman, A.D. (1995) Isolation and characterization of kinC, a gene that encodes a sensor kinase homologous to the sporulation sensor kinases KinA and KinB in Bacillus subtilis. J Bacteriol 177: 166-175
25. LeDeaux, J.R., Yu, N., and Grossman, A.D. (1995) Different roles for KinA, KinB, and KinC in the initiation of sporulation in Bacillus subtilis. J Bacteriol 177: 861-863
26. Lukat, G.S., Stock, A.M., and Stock, J.B. (1990) Divalent metal ion binding to the CheY protein and its significance to phosphotransfer in bacterial chemotaxis. Biochemistry 29: 5436-5442
27. Madhusudan, M., Zapf, J., Hoch, J.A., Whiteley, J.M., Xuong, N.H., and Varughese, K.I. (1997) A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: crystal structure of Spo0F from Bacillus subtilis. Biochemistry 36: 12739-12745
28. Ohlsen, K.L., Grimsley, J.K., and Hoch, J.A. (1994) Deactivation of the sporulation transcription factor Spo0A by the Spo0E protein phosphatase. Proc Natl Acad Sci USA 91: 1756-1760
29. Perego, M., and Hoch, J.A. (1996) Protein aspartate phosphatases control the output of two-component signal transduction systems. Trends Genet 12: 97-101
30. Perego, M., Hanstein, C., Welsh, K.M., Djavakhishvili, T., Glaser, P., and Hoch, J.A. (1994) Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis. Cell 79: 1047-1055
31. Perego, M., Glaser, P., and Hoch, J.A. (1996) Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis. Mol Microbiol 19: 1151-1157
32. Porter, S.C., North, A.K., Wedel, A.B., and Kustu, S. (1993) Oligomerization of NTRC at the glnA enhancer is required for transcriptional activation. Genes Dev 7: 2258-2273
33. Rowe-Magnus, D.A., and Spiegelman, G.B. (1998) Contributions of the domains of the Bacillus subtilis response regulator Spo0A to transcription stimulation of the spoIIG operon. J Biol Chem 273: 25818-25824
34. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
35. A RNA polymerase during sporulation in Bacillus subtilis. Proc Natl Acad Sci USA 88: 4533-4537
36. Satola, S.W., Baldus, J.M., and Moran, Jr, C.P. (1992) Binding of Spo0A stimulates spoIIG promoter activity in Bacillus subtilis. J Bacteriol 174: 1448-1453
37. Schuster, M., Abouhamad, W.N., Silversmith, R.E., and Bourret, R.B. (1998) Chemotactic response regulator mutant CheY95IV exhibits enhanced binding to the flagellar switch and phosphorylation-dependent constitutive signalling. Mol Microbiol 27: 1065-1075
38. Schyns, G., Buckner, C.M., and Moran, Jr, C.P. (1997). Activation of the Bacillus subtilis spoIIG promoter requires interaction of Spo0A and the sigma subunit of RNA polymerase. J Bacteriol 179: 5605-5608
39. Spiegelman, G., Van Hoy, B., Perego, M., Day, J., Trach, K., and Hoch, J.A. (1990) Structural alterations in the Bacillus subtilis Spo0A regulatory protein which suppress mutations at several spo0 loci. J Bacteriol 172: 5011-5019
40. Spiegelman, G.B., Bird, T.H., and Voon, V. (1995) Transcription regulation by the Bacillus subtilis response regulator Spo0A. In Two-Component Signal Transduction. Hoch, J.A., and Silhavy, T.J. (eds). Washington, DC: American Society for Microbiology Press, pp. 159-179.
41. Stock, A.M., Mottonen, J.M., Stock, J.B., and Schutt, C.E. (1989) Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis. Nature 337: 745-749
42. Stock, J.B., Surette, M.G., Levit, M., and Park, P. (1995) Two-component signal transduction systems: structure-function relationships and mechanisms of catalysis. In Two-Component Signal Transduction. Hoch, J.A., and Silhavy, T.J. (eds). Washington, DC: American Society for Microbiology Press, pp. 25-51
43. Strauch, M., Webb, V., Spiegelman, G., and Hoch, J.A. (1990) The Spo0A protein of Bacillus subtilis is a repressor of the abrB gene. Proc Natl Acad Sci USA 87: 1801-1805
44. Tzeng, Y.-L., and Hoch, J.A. (1997) Molecular recognition in signal transduction: the interaction surfaces of the Spo0F response regulator with its cognate phosphorelay proteins revealed by alanine scanning mutagenesis. J Mol Biol 272: 200-212
45. Volkman, B.F., Nohaile, M.J., Amy, N.K., Kustu, S., and Wemmer, D.E. (1995) Three-dimensional solution structure of the N-terminal receiver domain of NTRC. Biochemistry 34: 1413-1424
46. Volz, K. (1995) Structural and functional conservation in response regulators. In Two-Component Signal Transduction. Hoch, J.A., and Silhavy, T.J. (eds). Washington, DC: American Society for Microbiology Press, pp. 53-64
47. Wang, L., Grau, R., Perego, M., and Hoch, J.A. (1997) A novel histidine kinase inhibitor regulating development in Bacillus subtilis. Genes Dev 11: 2569-2579
48. Weiss, V., Claverie-Martin, F., and Magasanik, B. (1992) Phosphorylation of nitrogen regulator I of Escherichia coli induces strong cooperative binding to DNA essential for activation of transcription. Proc Natl Acad Sci USA 89: 5088-5092