Investigations on the mechanism of action of the novel antitumor agents 2-benzothiazolyl, 2-benzoxazolyl, and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine

Archiv der Pharmazie

Volumn 332, Issue 4, 1999, Pages 115-123

  Hall, Iris H ^a   Peaty, Nathanael J ^a,b   Henry, Jennifer R ^a   Easmon, Johnny ^c   Heinisch, Gottfried ^c   Pürstinger, Gerhard ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT ASHEVILLE   (United States)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

2 Acetylpyridine hydrazones; Antileukemic activity; DNA and purine synthesis inhibitors

Indexed keywords

2 ACETYLPYRIMIDINE DERIVATIVE; 2 BENZIMIDAZOLYLHYDROAZONE DERIVATIVE; 2 BENZOTHIAZOLYLHYDRAZONE DERIVATIVE; 2 BENZOXAZOLYLHYDARAZONE DERIVATIVE; ANTINEOPLASTIC AGENT; CYTARABINE; DIHYDROFOLATE REDUCTASE; EPH 116; EPH 52; EPH 57; EPH 61; ETOPOSIDE; FLUOROURACIL; HYDRAZONE DERIVATIVE; HYDROXYUREA; INOSINATE DEHYDROGENASE; MERCAPTOPURINE; PYRIDINE DERIVATIVE; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA CROSS LINKING; DNA SYNTHESIS INHIBITION; DRUG SCREENING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURINE SYNTHESIS; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 0032903677     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(19994)332:4<115::AID-ARDP115>3.0.CO;2-G     Document Type: Article

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