Comparative effect of chlormadinone acetate and diethylstilbestrol as promoters in mammary tumorigenesis of rats irradiated with γ-rays during lactation

Breast Cancer Research and Treatment

Volumn 53, Issue 2, 1999, Pages 153-160

  Inano, Hiroshi ^a   Suzuki, Keiko ^a   Onoda, Makoto ^a   Kobayashi, Hisae ^b   Wakabayashi, Katsumi ^b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Chlormadinone acetate; Diethylstilbestrol; Mammary tumorigenesis; Promoter

Indexed keywords

CHLORMADINONE; CHOLESTEROL; DIETHYLSTILBESTROL; ESTROGEN; GESTAGEN; PROLACTIN;

ANIMAL EXPERIMENT; ARTICLE; BREAST CELL; BREAST TUMOR; CANCER INCIDENCE; CARCINOGENESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ESTRADIOL BLOOD LEVEL; FEMALE; HYPOPHYSIS; LACTATION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RADIATION INJURY; TUMOR PROMOTION;

ANIMALS; CARCINOGENS; CHLORMADINONE ACETATE; DIETHYLSTILBESTROL; ESTRADIOL; FEMALE; GAMMA RAYS; LACTATION; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, RADIATION-INDUCED; PROLACTIN; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 0032903006     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006149608475     Document Type: Article

References (30)

1. 1. Inano H, Suzuki K, Onoda M, Yamanouchi H: Susceptibility of fetal, virgin, pregnant and lactating rats for the induction of mammary tumors by gamma rays. Radiat Res 145: 708-713, 1996
2. 2. Suzuki K, Ishii-Ohba H, Yamanouchi H, Wakabayashi K, Takahashi M, Inano H: Susceptibility of lactating rat mammary glands to gamma-ray irradiation-induced tumorigenesis. Int J Cancer 56: 413-417, 1994
3. 3. Yamanouchi H, Ishii-Ohba H, Suzuki K, Onoda M, Wakabayashi K, Inano H: Relationship between stages of mammary development and sensitivity to gamma-ray irradiation in mammary tumorigenesis in rats. Int J Cancer 60: 230-234, 1995
4. 4. Inano H, Yamanouchi H, Suzuki K, Onoda M, Wakabayashi K: Estradiol-17β as an initiation modifier for radiation-induced mammary tumorigenesis of rats ovariectomized before puberty. Carcinogenesis 16: 1871-1877, 1995
5. 5. Tucker HA, Reece RP: Nucleic acid content of rat mammary glands during post-lactational involution. Proc Soc Expt Biol Med 112: 1002-1004, 1963
6. 6. Walker NI, Bennett RE, Kerr JFR: Cell death by apoptosis during involution of the lactating breast in mice and rats. Am J Anat 185: 19-32, 1989
7. 7. Stranger R, Li F, Saurer S, Burkhardt A, Furus RR: Apoptotic cell death and tissue remodeling in mouse mammary gland involution. Development 115: 49-58, 1992
8. 8. Guenette RS, Corbeil HB, Leger J, Wong K, Mezl V, Mooibroek M, Tenniswood M: Induction of gene expression during involution of the lactating mammary gland of the rat. J Mol Endocrinol 12: 47-60, 1994
9. 9. Rothschild TC, Boylan ES, Calhoon RE, Vonderhaar BK: Transplacental effects of diethylstilbestrol on mammary development and tumorigenesis in female ACI rats. Cancer Res 47: 4508-4516, 1987
10. 10. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ: Comparative study of human and rat mammary tumorigenesis. Lab Invest 61: 244-278, 1990
11. 11. Watanabe G, Taya K, Sasamoto S: Dynamics of ovarian inhibin secretion during the oestrous cycles of rats. J Endocrinol 126: 151-157, 1990
12. 12. Johnson RB, Nakamura RM, Libby RM: Simplified Scatchard plot assay for estrogen receptor in human breast tumor. Clin Chem 21: 1715-1730, 1975
13. 13. Johnson RB, Nakamura RM: Simplified Scatchard plot assay for progesterone receptor in breast cancer: Comparison with single-point and multipoint assay. Clin Chem 24: 1170-1176, 1978
14. 14. Scatchard G: The attractions of proteins for small molecules and ions. Ann NY Acad Sci USA 51: 660-672, 1949
15. 15. Holtzman S, Stone JP, Shellabarger CJ: Radiation-induced mammary carcinogenesis in virgin, pregnant, lactating and postlactating rats. Cancer Res 42: 50-53, 1982
16. 60Co-irradiation. Carcinogenesis 12: 1085-1090, 1991
17. 17. Dauvois S, Labrie F: Androstenedione and androst-5-ene-3β, 17β-diol stimulate DMBA-induced rat mammary tumors. Role of aromatase. Breast Cancer Res Treat 13: 61-69, 1989
18. 18. Amenomori Y, Chen CL, Meites J: Serum prolactin levels in rats during different reproductive states. Endocrinology 86: 506-510, 1970
19. 19. Inano H, Suzuki K, Ishii-Ohba H, Yamanouchi H, Takahashi M, Wakabayashi K: Promotive effects of diethylstilbestrol, its metabolite (Z,Z-dienestrol) and a stereoisomer of the metabolite (E,E-dienestrol) in tumorigenesis of rat mammary glands pregnancy-dependently initiated with radiation. Carcinogenesis 14: 2157-2163, 1993
20. 20. Oliveira MC, Spritzer P, Poy M, Coronel AX, Dahlem N, Moraes JT, Barbosa-Coutinho LM: Progestin effects on prolactin secretion and on immunoreactive prolactin cells in estradiol-treated ovariectomized rats. Hormone Metab Res 25: 600-602, 1993
21. 21. Maurer RA: Estradiol regulates the transcription of the prolactin gene. J Biol Chem 257: 2133-2136, 1982
22. 22. Zinder O, Hamosh M, Fleck TRC, Scow RO: Effect of prolactin on lipoprotein lipase mammary gland and adipose tissue of rats. Am J Physiol 226: 744-748, 1974
23. 23. Flint DJ, Clegg RA, Knight CH: Effects of prolactin, progesterone and ovariectomy on metabolic activities and insulin receptors in the mammary gland and adipose tissue during extended lactation in the rat. J Endocrinol 102: 231-236, 1984
24. 24. Pazos P, Lanari C, Meiss R, Charreau EH, Pasqualini CD: Mammary carcinogenesis induced by N-methyl-N-nitrosourea (MNU) and medroxyprogesterone acetate (MPA) in BALB/c mice. Breast Cancer Res Treat 20: 133-138, 1991
25. 25. Pazos P, Lanari C, Elizalde P, Montecchia F, Charreau EH, Molinolo AA: Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice. Carcinogenesis 19: 529-531, 1998
26. 26. Butler C, Hill H: Chlormadinone acetate as oral contraceptive. Lancet 1(7606): 1116-1119, 1969
27. 27. Nischan P, Ebeling K: Oral contraceptive containing chlormadinone acetate and cancer incidence at selected sites in the German Democratic Republic. A correlation analysis. Int J Cancer 34: 671-674, 1984
28. 28. Declercq G, Bedes P: The effects of chlormadinone acetate upon estradiol uptake by the rat mammary glands in organ culture. Am J Obstet Gynecol 118: 1050-1053, 1974
29. 29. Beck P, Molarkey WB: Serum prolactin concentrations in women treated with chlormadinone acetate. Am J Obstet Gynecol 124: 578-581, 1976
30. 30. Tominaga T, Kitamura M, Saito T, Itoh I: Effects of hexestrol, medroxyprogesterone acetate and chlormadinone acetate on 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer in relation to estrogen receptor. Gann 72: 604-609, 1981