Human herpes virus-6 seroprevalence and leukaemias: A case-control study

British Journal of Cancer

Volumn 80, Issue 7, 1999, Pages 1103-1106

  Gentile, G ^a   Mele, A ^b   Ragona, G ^a,c   Faggioni, A ^a   Zompetta, C ^a   Tosti, M E ^b   Visani, G ^d   Castelli, G ^e   Pulsoni, A ^a   Monarca, B ^a   Martino, P ^a   Mandelli, F ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c IRCCS NEUROMED   (Italy)

^d Istituto di Ematologia Seragnoli   (Italy)

^e FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

HHV 6; Leukaemia; Viral aetiology

Indexed keywords

VIRUS ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN HERPESVIRUS 6; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REFRACTORY ANEMIA; SEROPREVALENCE;

ADOLESCENT; ADULT; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; ANTIBODIES, VIRAL; CASE-CONTROL STUDIES; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; RISK FACTORS; SEROEPIDEMIOLOGIC STUDIES;

EID: 0032903005     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690471     Document Type: Article

References (25)

1. Ablashi DV, Lusso P, Hung C-L, Salahuddin SZ, Josephs SF, Llana T. Kramarsky B, Biberfeld P, Markham PD and Gallo RC (1988a) Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (Human Herpesvirus 6). Int J Cancer 42: 787-791
2. Ablashi DV, Josephs SF, Buchbinder C, Hellman K, Nakamura S, Llana T, Lusso P, Kaplan M, Dahlberg J, Memon S, Iman F, Ablashi KL, Markham PD, Kramarsky B, Krueger GRF, Biberfeld P, Wong-Staal F, Salahuddin SZ and Gallo RC (1988b) Human B-lymphotropic virus (human herpesvirus 6). J Virol Methods 21: 29-48
3. Braun DK, Pellett PE and Hanson CA (1995) Presence and expression of human herpesvirus 6 in peripheral blood mononuclear cells of S100-positive, T-cell chronic lymphoproliferative disease. J Infect Dis 171: 1351-1355
4. Braun DK, Dominguez G and Pellet PE (1997) Human herpes virus 6. Clin Microbiol Rev 10: 521-567
5. Clark DA, Alexander FE, McKinney PA, Roberts BE, O'Brien C, Jarrett RF, Cartwright RA and Onions DE (1990) The seroepidemiology of human herpesvirus-6 (HHV-6) from a case-control study of leukaemia and lymphoma. Int J Cancer 45: 829-833
6. Di Luca D, Dolcetti R, Mirandola P, De Re V, Secchiero P, Carbone A, Boiocehi M and Cassai E (1994) Human herpesvirus 6: a survey of presence and variant distribution in normal peripheral lymphocytes and lymphopioliferative disorders. J Infect Dis 170: 211-215
7. Josephs SF, Buchbinder A, Streicher HZ, Ablashi DV, Salahuddin SZ, Guo H-G, Wong-Staal F, Cossman J, Raffeld M, Sundeen J, Levine P, Biggar R, Krueger GRF, Fox RI and Gallo RC (1988) Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients. Leukemia 2: 132-135
8. Krueger GRF, Klueppelberg U, Hoffmann A and Ablashi DV (1994) Clinical correlates of infection with human herpesvirus-6. In Vivo 8: 457-486
9. Levine PH, Ablashi DV, Saxinger WC and Connelly RR (1992a) Antibodies to human herpes virus-6 in patients with acute lymphocytic leukemia. Leukemia 6: 1229-1231
10. Levine PH, Neequaye J, Yadav M and Connelly R (1992b) Geographic/ethnic differences in human herpesvirus-6 antibody patterns. Microbiol Iinmunol 36: 169-172
11. Levy JA, Ferro F, Greenspan D and Lennette ET (1990) Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet 1: 1047-1050
12. Luka J, Pirruccello SJ and Kersey JH (1991) HHV-6 genome in T-cell acute lymphoblastic Leukemia. Lancet 338: 1277-1270
13. Luppi M, Marasca R, Barozzi P, Ferrari S, Ceccherini-Nelli L, Batoni G, Merelli E and Torelli G (1993) Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 40: 44-52
14. Mele A, Szklo M, Visani G, Stazi MA, Castelli G, Pasquini P, Mandelli F and the Italian Leukemia Study Group (1994) Hair dye use and other risk factors for leukemia and pre-leukemia: a case-control study. Am J Epidemiol 139: 609-619
15. Okuno T, Takahashi K, Balachandra K, Shiraki K, Yamanishi K, Takahashi M and Baba K (1989) Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol 27: 651-653
16. Ragona G, Calogero A, Cirone M, Cuomo L, Gonnella R, Zompetta C, Gentile G, Martino P, Menichella D, Frati L and Faggioni A (1994) HHV-6 infection in Italy: characterization of an endemic isolate and seroepidemiologic analysis. Clin Diagn Virol 1: 261-270
17. Ragona G, Angeloni A, Farina A, Faggioni A, Frati L, Calogero A, Gentile G, Martino P, Arcese W and Mandelli F (1995) Subclinical infection of the respiratory tract of immunocompromised patients by human herpesvirus-6. Blood 85: 295-296
18. Razzaque A (1990) Oncogenic potential of human herpesvirus-6 DNA. Oncogene 5: 1365-1370
19. Razzaque A, Williams O, Wang T and Rhim JS (1993) Neoplastic transformation of immonalized human epidermal keratinocytes by two HHV-6 DNA clones. Virology 195: 113-120
20. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sterzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B and Gallo RC (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234: 596-601
21. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, Gallo RC and Lusso P (1995) Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 171: 273-280
22. Thompson J, Choudhury S, Kashanebi F, Doniger J, Berneman Z, Frenkel N and Rosenthal LJ (1994) A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1. Oncogene 9: 1167-1175
23. Torelli G, Marasca R, Luppi M, Selleri L, Ferrari S, Nami F, Mariano MT, Federico M, Ceccherini-Nelli L, Bendinelli M, Montagnani G, Montorsi M and Artusi T (1991) Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction. Blood 77: 2251-2258
24. Wilborn F, Schmidt CA, Zimmermann R, Brinkmann V, Neipel F and Siegert W (1994) Detection of herpesvirus type 6 by polymerase chain reaction in blood donors: random tests and prospective longitudinal study. Br J Haematol 88: 187-192
25. Yanagi K, Harada S, Ban F, Oya A, Okabe N and Tobinai K (1990) High prevalence of antibody to human herpesvirus-6 and decrease in titer with increase in age in Japan. J Infect Dis 161: 153-154