Sensitivity to the discriminative stimulus and antinociceptive effects of μ opioids: Role of strain of rat, stimulus intensity, and intrinsic efficacy at the μ opioid receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 965-975

  Morgan, Drake ^a,b   Cook, Charles D ^a   Picker, Mitchell J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; BUTORPHANOL; LEVORPHANOL; MORPHINE; MU OPIATE RECEPTOR; NALBUPHINE; OPIATE AGONIST;

ANIMAL EXPERIMENT; ANTINOCICEPTION; CONFERENCE PAPER; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; INTRAPERITONEAL DRUG ADMINISTRATION; LATENT PERIOD; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; STRAIN DIFFERENCE; TEMPERATURE; WITHDRAWAL REFLEX;

ANALGESICS, OPIOID; ANIMALS; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; PAIN MEASUREMENT; RATS; RATS, INBRED F344; RATS, INBRED LEW; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SPECIES SPECIFICITY; TEMPERATURE;

EID: 0032902563     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (39)

1. Adams JU, Paronis CA and Holtzman SG (1990) Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using B-funaltrexamine. J Pharmacol Exp Ther 255:1027-1032.
2. Ambrosio E, Goldberg SR and Elmer GI (1996) Behavior genetic investigation of the relationship between spontaneous locomotor activity and the acquisition of morphine self-administration behavior. Behav Pharmacol 6:229-237.
3. Baran A, Shuster L, Eleftheriou BE and Bailey DW (1975) Opiate receptors in mice: Genetic differences. Life Sci 17:633-640.
4. Beitner-Johnson D, Guitart X and Nestler EJ (1991) Dopaminergic brain reward regions of Lewis and Fischer rats display different levels of tyrosine hydroxylase and other morphine- and cocaine-regulated phosphoproteins. Brain Res 561:147-150.
5. Butelman ER, Winger G, Zernig G and Woods JH (1995) Butorphanol: Characterization of agonist and antagonist effects in rhesus monkeys. J Pharmacol Exp Ther 272:845-863.
6. Carroll ME, Pederson MC and Harrison RG (1986) Food deprivation reveals strain differences in opiate intake of Sprague-Dawley and Wistar rats. Pharmacol Biochem Behav 24:1095-1099.
7. Elmer GI, Pieper JO, Goldberg SR and George FR (1995) Opioid operant self-administration, analgesia, stimulation and respiratory depression in μ-deficient mice. Psychopharmacology 117:23-31.
8. France CP and Woods JH (1990) Discriminative stimulus effects of opioid agonists in morphine-dependent pigeons. J Pharmacol Exp Ther 254:626-632.
9. Gosnell BA and Krahn DD (1993) Morphine-induced feeding: A comparison of the Lewis and Fischer 344 inbred rat strains. Pharmacol Biochem Behav 44:919-924.
10. Guitart X, Beitner-Hohnson D, Marby DW, Kosten TA and Nestler EJ (1992) Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system. Synapse 12:242-253.
11. Guitart X, Kogan JH, Berhow M, Terwilliger RZ, Aghajanian GK and Nestler EJ (1993) Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: Studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals. Brain Res 611:7-17.
12. Holtzman SG (1997) Antagonism of morphine-like discriminative effects by beta-funaltrexamine. Pharmacol Biochem Behav 57:771-777.
13. Hyyatia P and Sinclair JD (1993) Oral etonitazene and cocaine consumption by AA, ANA and Wistar rats. Psychopharmacology 111:409-414.
14. Jaeger TV and van der Kooy D (1993) Morphine acts in the parabrachial nucleus, a pontine viscerosensory relay, to produce discriminative stimulus effects. Psychopharmacology 110:76-84.
15. Jensen TS (1997) Opioids in the brain: Supraspinal mechanisms in pain control. Acta Anaesthesiol Scand 41:123-132.
16. Kamei J, Morita K, Saitoh A, Suzuki T and Nagase H (1996) Antinociceptive and antitussive effects of morphine in the DA-bg/bg (Beige) rat. Eur J Pharmacol 300:75-78.
17. Marley RJ, Elmer GI and Goldberg SR (1992) The use of pharmacogenetic techniques in drug abuse research. Pharmacol Ther 53:217-237.
18. Morgan D, Cook CD, Smith MA and Picker MJ (1999) An examination of the interactions between the antinociceptive effects of morphine and various μ-opioids: The role of intrinsic efficacy and stimulus intensity. Anesth Analg 88:407-413.
19. Morgan D and Picker MJ (1996) Contribution of individual differences to discriminative stimulus, antinociceptive and rate-decreasing effects of opioids: Importance of the drug's intrinsic efficacy at the mu receptor. Behav Pharmacol 7:261-284.
20. O'Callaghan JP and Holtzman SG (1975) Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J Pharmacol Exp Ther 192:497-505.
21. Paronis CA and Holtzman SG (1992) Development of tolerance to the analgesic activity of mu agonists after continuous infusion of morphine, meperidine or fentanyl in rats J Pharmacol Exp Ther 262:1-9.
22. Picker MJ, Yarbrough J, Hughes CE, Smith MA, Morgan D and Dykstra LA (1993) Agonist and antagonist effects of mixed action opioids in the pigeon drug discrimination procedure: Influence of training dose, intrinsic efficacy and interanimal differences J Pharmacol Exp Ther 266:756-767.
23. Selley DE, Sim LJ, Xiao R, Liu Q and Childers SR (1997) mu-Opioid receptor-stimulated guanosine-5′-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: Signal transduction mechanisms underlying agonist efficacy. Mol Pharmacol 51:87-96.
24. Shoaib M and Spanagel R (1994) Mesolimbic sites mediate the discriminative stimulus effects of morphine. Eur J Pharmacol 252:69-75.
25. Shoaib M, Spanagel R, Stohr T and Shippenberg TS (1995) Strain differences in the rewarding and dopamine-releasing effects of morphine in rats. Psychopharmacology 117:240-247.
26. Strecker RE, Eberle WF and Ashby CR Jr (1995) Extracellular dopamine and its metabolites in the nucleus accumbens of Fischer and Lewis rats: Basal levels and cocaine-induced changes. Life Sci 56:PL135-PL141.
27. Sudakov SK, Borisova EV and Lyupina YV (1996) Influence of inheritance and fostering on sensitivity to effects of morphine on nociception and locomotor activity in two inbred rat strains. Neuropharmacology 35:1131-1134.
28. Sudakov SK, Goldberg SR, Borisova EV, Surkova LA, Turina IV, Rusakov DJ and Elmer GI (1993) Differences in morphine reinforcement property in two inbred rat strains: Associations with cortical receptors, behavioral activity, analgesia and the cataleptic effects of morphine. Psychopharmacology 112:183-188.
29. Suzuki T, George FR and Meisch RA (1992) Etonitazene delivered orally serves as a reinforcer for Lewis but not Fischer 344 rats. Pharmacol Biochem Behav 42:579-586.
30. Suzuki T, Otani K, Koike Y and Misawa M (1988) Genetic differences in preferences for morphine and codeine in Lewis and Fischer 344 inbred rat strains. Jpn J Pharmacol 47:425-431.
31. Tiano MJ, Walker EA and Dykstra LA (1998) Cross-tolerance to etorphine differentiates μ-opioid agonists in a rat tail withdrawal assay. Analgesia 3:251-257.
32. Vaccarino AL and Couret LC Jr (1995) Relationship between hypothalamic-pituitary-adrenal activity and blockade of tolerance to morphine analgesia by pain: A strain comparison. Pain 63:385-389.
33. Walker EA, Butelman ER, DeCosta BR and Woods JH (1993) Opioid thermal antinociception in rhesus monkeys: Receptor mechanisms and temperature dependency. J Pharmacol Exp Ther 267:280-286.
34. 2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats. J Pharmacol Exp Ther 271:959-968.
35. Witkin JM and Goldberg SR (1990) Effects of cocaine on locomotor activity and schedule-controlled behaviors of inbred rat strains. Pharmacol Biochem Behav 37:339-342.
36. Woolfolk DR and Holtzman SG (1995) Rat strain differences in the potentiation of morphine-induced analgesia by stress. Pharmacol Biochem Behav 51:699-703.
37. Yaksh TL (1997) Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 41:94-111.
38. Young AM, Masaki MA and Geula C (1992) Discriminative stimulus effects of morphine: Effects of training dose on agonist and antagonist effects of mu opioids. J Pharmacol Exp Ther 261:246-257.
39. Zimmerman DM, Leander JD, Reel JK and Hynes MD (1987) Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands. J Pharmacol Exp Ther 241:374-378.