Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: A commentary

International Journal of Antimicrobial Agents

Volumn 11, Issue 1, 1999, Pages 7-12

  Chow, Joseph W ^a   Yu, Victor L ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Combination antimicrobial therapy; Enterobacter spp.; Gram negative bacteraemia; Klebsiella spp.; Monotherapy; Pseudomonas aeruginosa

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CEFOPERAZONE; CEFTAZIDIME; GENTAMICIN; IMIPENEM; PIPERACILLIN; TOBRAMYCIN;

BACTEREMIA; ENTEROBACTER; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HUMAN; KLEBSIELLA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW;

ANTI-BACTERIAL AGENTS; BACTEREMIA; CLINICAL TRIALS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GRAM-NEGATIVE BACTERIA; HUMANS; TREATMENT OUTCOME;

EID: 0032902551     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(98)00060-0     Document Type: Review

References (16)

1. EORTC International Antimicrobial Therapy Group Ceftazidime combined with short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. N Engl J Med. 317:1987;1692-1698.
2. Hilf M., Yu V.L., Sharp J., Zuravleff J.J., Korvick J.A., Muder R.R. Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients. Am J Med. 87:1989;540-546.
3. Korvick J.A., Bryan C.S., Farber B., Beam T.R. Jr., Schenfeld L., Muder R.R., Weinbaum D., Lumish R., Gerding D.N., Wagener M., Yu V.L. Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy. Antimicrob Agents Chemother. 12:1992;2639-2644.
4. Feldman C., Smith C., Lexy H., Ginsburg P., Miller S.D. Koornhof. Klebsiella pneumoniae bacteremia at an urban general hospital. J Infect. 20:1990;21-31.
5. Bodey G.P., Elting L.S., Rodriguez S., Hernandez M. Klebsiella bacteremia. A 10-year review in a cancer institution. Cancer. 64:1989;2368-2376.
6. Kreger B.E., Craven D.E., McCabe W.R. Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med. 68:1980;344-355.
7. Fainstein V., Bodey G.P., Etting L., Bolivar R., Keating M.J., McCredie K.B., Valvidivieso M. A randomized study of ceftazidime compared to ceftazidime and tobramycin for the treatment of infections in cancer patients. J Antimicrob Chemother. 12(Suppl A):1983;101-110.
8. Piccart M., Klastersky J., Meunier F., Lagast H., Van Laethem Y., Weerts D. Single-drug versus combination empirical therapy for gram-negative bacillary infections in febrile cancer patients with and without granulocytopenia. Antimicrob Agents Chemother. 26:1984;870-875.
9. Chow J.W., Fine M.J., Shlaes D.M., Quinn J.P., Hooper D.C., Johnson M.P., Ramphal R., Wagener M., Miyashiro D.K., Yu V.L. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Arch Intern Med. 115:1991;585-590.
10. Leyland M.J., Bayston K.F., Cohen J., Warren R., Newland A.C., Bint A.J., Cefai C., White D.G., Murray S.A., Bareford D., Deaney N.B. A comparative study of imipenem versus piperacillin plus gentamicin to the initial management of febrile neutropenic patients with haematological malignancies. J Antimicrob Chemother. 30:1992;843-854.
11. Leibovici L., Paul M., Poznanski O., Drucker M., Samra Z., Konigsberger H., Pitlik S.D. Monotherapy versus β-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study. Antimicrob Agents Chemother. 41:1997;1127-1133.
12. Bodey G.P., Elting L.S., Rodriguez S. Bacteremia caused by Enterobacter: 15 years of experience in a cancer hospital. Rev Infect Dis. 13:1991;550-558.
13. Leibovici L. Monotherapy versus beta-lactam-aminoglycoside combination therapy for gram-negative bacteremia (Letter). Antimiocrob Agents Chemother. 41:1997;2593-2594.
14. Anderson E.T., Young L.S., Hewitt W. Antimicrobial synergism in the therapy of gram-negataive rod bacteremia. Chemotherapy. 24:1978;45-54.
15. De Jongh C.A., Joshi J.H., Newman K.A., Moody M.R., Wharton R., Standiford H.C., Schimpff S.C. Antibiotic synergism and response in Gram-negative bacteremia in granulocytopenic cancer patients. Am J Med. 80:1986;96-100.
16. Paterson DL, Robson JMB, Wagener MW. Risk factors for toxicity in elderly patients given once-daily dosing of aminoglycosides. J Gen Intern Med 1998;13:735-739.