Shared rheumatoid epitope as a risk factor in determining outcome in rheumatoid arthritis

Australian and New Zealand Journal of Medicine

Volumn 29, Issue 2, 1999, Pages 234-238

  Hedger, S C ^a   Macardle, P ^a   Bond, M J ^b   Ahern, M J ^a   Smith, M D ^a   Roberts Thomson, P J ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

Disease outcome; DR; Flow cytometry; Health Assessment Questionnaire; Major histocompatibility complex; Rheumatoid arthritis; Rheumatoid epitope

Indexed keywords

EPITOPE;

AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; GENOTYPE; GOLD THERAPY; HUMAN; MALE; OUTCOMES RESEARCH; RHEUMATOID ARTHRITIS; RISK FACTOR;

EID: 0032901639     PISSN: 00048291     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1445-5994.1999.tb00689.x     Document Type: Article

References (12)

1. 1. Nepom BS, Nepom GT. Polyglot and polymorphism. An HLA update. Arthritis Rheum 1995; 38: 1715-21.
2. 2. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
3. 3. Wicks I, McColl G, D'Amico A, Dougherty L, Tait B. Use of monoclonal antibodies to detect disease associated HLA-DRB1 alleles and the shared epitope in rheumatoid arthritis. Ann Rheum Dis 1997; 56: 135-9.
4. 4. Weyand CM, Hicok KC, Conn DL, Goronzy JJ. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992; 117: 801-6.
5. 5. Moreno I, Valenzuela A, Garcia A, Yelamos J, Sanchez B, Hernanz W. Association of the shared epitope with radiological severity of rheumatoid arthritis. J Rheumatol 1996; 23: 6-9.
6. 6. Gough A, Faint J, Salmon M et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 1994; 37: 1166-70.
7. 7. Symmons DPM, Ollier WER, Brennan P, Silman AJ. Should patients with recent onset rheumatoid arthritis be offered genetic screening? Ann Rheum dis 1996; 55: 407-10.
8. 8. Van der Heide A, Remme CA, Hofman DM, Jacobs JWG, Bijlsma JWJ. Prediction of progression of radiologic damage in newly diagnosed rheumatoid arthritis. Arthritis Rheum 1995; 38: 1466-74.
9. 9. van Leeuwen MA, van Rijswijk MH, van der Heijde DMFM et al. The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: A prospective study during the first three years of the disease. Br J Rheumatol 1993; (Suppl. 3) 32: 9-13.
10. 10. Heytman M, Ahern MJ, Smith MD, Roberts-Thomson PJ. The longterm effect of pulsed corticosteroids on the efficacy and toxicity of chrysotherapy in rheumatoid arthritis. J Rheumatol 1994; 21: 435-41.
11. 11. O'Dell JR, Nepom BS, Haire C et al. HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments. Ann Rheum Dis 1998; 57: 209-13.
12. 12. Marshall WH, Drover S, Larsen BA, Codner D, Copp MD et al. Assessing prognosis in rheumatoid arthritis using monoclonal antibodies and flow cytometry. In: Madrigal AJ, Bencovà M, Middleton D, Charron D, Nànàsi T (Eds). Immunogenetics: Advances and Education. Netherlands: Kluwer Academic Publishers, 1997: 87-98.