Occurrence of heavy chain of 7S IgM half-molecule whose NH2-terminal sequence is identical with that of κ light chain sequence in patients with Waldenstrom macroglobulinemia

Clinica Chimica Acta

Volumn 282, Issue 1-2, 1999, Pages 77-88

  Imoto, Mayumi ^a   Ishikawa, Kinji ^a   Yamamoto, Kazuhiko ^b   Sinohara, Hyogo ^b   Irimajiri, Kiyohiro ^a   Kubo, Nobuhiko ^c   Sakurabayashi, Ikunosuke ^c   Horiuchi, Atushi ^a   Akiyama, Toshiyuki ^a   Ohba, Yasuhiro ^a   Furuta, Itaru ^a  

^a KINDAI UNIVERSITY HOSPITAL   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Half molecule 7S IgM(HM 7S IgM); NH2 terminal amino acid sequence; Waldenstrom macroglobulinemia

Indexed keywords

IMMUNOGLOBULIN 7S; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN MU CHAIN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; BLOOD ANALYSIS; CASE REPORT; DATA BASE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; URINALYSIS; WALDENSTROEM MACROGLOBULINEMIA;

AMINO ACID SEQUENCE; HUMANS; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PAPAIN; SEQUENCE ALIGNMENT; WALDENSTROM MACROGLOBULINEMIA;

EID: 0032900849     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(99)00020-0     Document Type: Article

References (22)

1. Potter M., Kuff E.L. Disorders in the differentiation of protein secretion in neoplastic plasma cells. J Mol Biol. 9:1964;537-544.
2. Hobbs J.R., Jacobs A. A half-molecule GK plasmacytoma. Clin Exp Immunol. 5:1969;199-207.
3. Spiegelberg H.L., Fishkin B.G. Human Myeloma IgA half-molecules. J Clin Invest. 58:1976;1259-1265.
4. Sakurabayashi I., Kin K., Kawai T. Human IgA1 half-molecules: clinical and immunologic features in a patient with multiple myeloma. Blood. 53:1979;269-278.
5. Solomon A., Kunkel H.G. A "monoclonal" type, low molecular weight protein related to γ M-macroglobulins. Am J Med. 42:1967;958-967.
6. Grabar P., Williams C.A. Me'thode permettant l′e'tude conjugue′e proprie'te's e'lectrophore'tiques et immunochimiques d'un me'lange de prote'ines. Application au se'rum sanguin. Bioch Acta. 10:1953;193-194.
7. Laemmli U.K. Cleavage of structural proteins during the assembly the head of bacteriophage T4. Nature. 227:1970;680-685.
8. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 76:1979;4350-4354.
9. Yamamoto K., Sinohara H. Isolation and characterisation of mouse countertrypin, a new trypsin inhibitor belonging to the mammalian fetuin family. J Biol Chem. 268:1993;17750-17753.
10. Cleveland D.W., Fischer S.G., Kirschner M.W., Laemmli U.K. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem. 252:1977;1102-1106.
11. Bentley D.L. Most κ immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes. Nature. 307:1984;77-80.
12. Watanabe S., Barnikol H.U., Horn J., Bertram J., Hilschmann N. Die Primarstruktureines monoklonalen IgM-immunoglobulins (Macroglobulin Gal) II Die aminosauresequenz der H-kette(μ-typ Subgruppe H III) struktur des gesamten IgM-molekuls. Hoppe-Seyler′s Z Physiol Chem. 354:1973;1505-1509.
13. Takahashi N., Tetaert D., Debuire B., Lin L.C., Putnam F.W. Complete amino acid sequence of the σ heavy chain of human immunoglobulin D. Proc Natl Acad Sci USA. 79:1982;2850-2854.
14. Cogn′e M., Silvain C., Khamlichi A.A., Preud′homme J.L. Structurally abnormal immunoglobulins in human immunoproliferative disorders. Blood. 79:1992;2181-2195.
15. Spiegelberg H.L., Heath V.C., Lang J.E. Human myeloma IgG half-molecules. Structural and antigenic analyses. Biochemistry. 14:1975;2157-2163.
16. Spiegelberg H.L., Heath V.C., Eugene-Lang J. IgG half-molecules: clinical and immunologic features in a patient with plasma cell leukemia. Blood. 45:1975;305-313.
17. Kang Y.S., Shim B.S. An abnormal human IgA1 half-molecule. Biochim Biophys Acta. 494:1977;326-331.
18. Tonegawa S. Somatic generation of antibody diversity. Nature. 302:1983;575-581.
19. Guglielmi P., Bakhshi A., Cognõe M., Seligmann M., Korsmeyer S. Multiple genomic defects result in an alternative RNA splice creating a human γ H chain disease protein. J Immunol. 141:1988;1762-1768.
20. Alexander A., Anicito I., Buxbaum J. Gamma heavy chain disease in man: genomic sequence reveals two non-contiguous deletions in a single gene. J Clin Invest. 82:1988;1244-1252.
21. Meyer J., Jack H.M., Ellis N., Wabl M. High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene. Proc Natl Acad Sci USA. 83:1986;6950-6953.
22. Weber J.S., Berry J., Manser T., Claflin J.L. Position of the rearranged V κ and its 5′ flanking sequences determines the location of somatic mutations in the J κ locus. Immunol. 146:1991;3652-3655.