Accuracy of preimplantation diagnosis of single-gene disorders by polar body analysis of oocytes

Journal of Assisted Reproduction and Genetics

Volumn 16, Issue 4, 1999, Pages 192-198

  Rechitsky, S ^a   Strom, C ^a   Verlinsky, O ^a   Amet, T ^a   Ivakhnenko, V ^a   Kukharenko, V ^a   Kuliev, A ^b   Verlinsky, Y ^a  

^a REPRODUCTIVE GENETICS INSTITUTE   (United States)

^b NONE

Author keywords

Allele dropout; First and second polar bodies; Multiplex PCR; Preimplantation diagnosis; Single gene disorders

Indexed keywords

DNA;

CONFERENCE PAPER; DIAGNOSTIC ACCURACY; DNA POLYMORPHISM; EMBRYO; EMBRYO TRANSFER; GENE AMPLIFICATION; GENETIC ANALYSIS; GENETIC DISORDER; HUMAN; OOCYTE; POLYMERASE CHAIN REACTION; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; SEQUENTIAL ANALYSIS;

ALLELES; CYSTIC FIBROSIS; FEMALE; GAUCHER DISEASE; GENETIC DISEASES, INBORN; HUMANS; OOCYTES; POLYMERASE CHAIN REACTION; PREGNANCY; PREIMPLANTATION DIAGNOSIS;

EID: 0032900801     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020312823155     Document Type: Conference Paper

References (8)

1. Rechitsky S, Freidine M, Verlinsky Y, Strom C: Allele drop-out in sequential analysis of single cells by PCR and FISH. J Assist Reprod Genet 1996,13:115-124
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3. Ray P, Winston R, Handyside A: Reduced allele drop-out in single cell analysis for preimplantation genetic diagnosis of cystic fibrosis. J Assist Reprod Genet 1996;13:104-106
4. Rechitsky S, Strom C, Verlinsky O, Amet T, Ivakhnenko V, Kukharenko V, Kuliev A, Verlinsky Y: Allele dropout in polar bodies and blastomeres. J Assist Reprod Genet 1998;15(5):253-257
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6. Kuliev A, Rechitsky S, Verlinsky O, Ivakhnenko V, Evsikov G, Wolf G, Angastiniotis M, Georghiou D, Kukharenko V, Strom C, Verlinsky Y: Preimplantation diagnosis of thalassemias. J Assist Reprod Genet 1998;15(5):219-225
7. Kuliev A, Rechitsky S, Verlinsky O, Ivakhnenko V, Cieslak J, Evsikov S, Wolf G, Angastiniotis M, Kalakoutis G, Strom C, Verlinsky Y: Birth of healthy children after preimplantation diagnosis of thalassemias. J Assist Reprod Genet 1999;16: 184-188
8. Ijlst L, Ruiter JP, Vreijling J, Wanders RJ: Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. A new method to identify the G1528C mutation in genomic DNA showing its high frequency (≈90%) and identification of a new mutation (T2198C). J Inher Metab Dis 1996;19:165-168