Cytotoxicity and mode of action of aliphatic dicarboxylic acids in L1210 lymphocytic leukemia cells

Anticancer Research

Volumn 19, Issue 1 A, 1999, Pages 205-211

  Hall, Iris H ^a   Izydore, Robert A ^b   Warren, Amy E ^a   Barnes, Cheryl R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

Dicarboxylic acid antineoplastic agents; Nucleoside kinase and de novo purine inhibitors

Indexed keywords

2,2 DIMETHYLMALONIC ACID; AMINOTRANSFERASE; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; AZAURACIL; CYTARABINE; DIBUTYLMALONIC ACID; DICARBOXYLIC ACID; DIETHYLMALONANILIDE; DIETHYLMALONIC ACID; ETHYLMALONIC ACID; ETOPOSIDE; FLUOROURACIL; FUMARIC ACID; INOSINATE DEHYDROGENASE; MALEIC ACID; MALIC HYDRAZIDE; MALONIC ACID; MERCAPTOPURINE; N BUTYLMALONIC ACID; PHENYLMALONIC ACID; PHOSPHOTRANSFERASE; PHTHALIC HYDRAZIDE; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG MECHANISM; GLIOMA; HELA CELL; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA; LUNG CANCER; LYMPHATIC LEUKEMIA; LYMPHOMA; MALE; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; PURINE SYNTHESIS; RNA SYNTHESIS; SOLID TUMOR; UTERUS CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; DICARBOXYLIC ACIDS; DNA; DNA FRAGMENTATION; HELA CELLS; HUMANS; LEUKEMIA L1210; MALE; MICE; RATS;

EID: 0032900026     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Hall IH, Izydore RA, Vital TS, Chen SY, Miller MC III, Bernal-Ramirez JA, Okwisa WA, Rajendran KG: The cytotoxic activity of 1-acyl and 1,2-acyl-4,4-diethyl-3,5-pyrazolidinediones. Anticancer Res 15: 199-204, 1995.
2. Hall IH, Wing OT, Scovill JP: The cytotoxicity of N-pyridinyl and N-quinolinyl substituted derivatives of phthalimide and succinimide, Biomed & Pharmacother 5: 252-258, 1995.
3. Hall IH, Wong OT, Chi LK, Chen SY: Cytotoxicity and mode of action of substituted indan-1,3-diones in murine and human tumor cells. Anticancer Res 14: 2053-2058, 1994.
4. Hall IH, Chapman JM, Wong OT: Cytotoxicity of cyclic-imido alkylethers, thioethers, sulfoxide, sulfones and related derivatives, Anti-Cancer Drugs 5: 75-82, 1994.
5. Sajadi Z, Abrishami MM, Mohseni P, Chapman JM Jr, Hall IH: The Synthesis and Evaluation of Antitumor Properties of Esters of 2-Furoic Acid and 2-Furanacrylic Acid, J Pharm Sci 73: 266-267, 1984.
6. Speck SB: Condensation of substituted malonic esters and diamines. JAM Chem Soc 74, 2876-2878, 1952.
7. Sood CK, Sood A, Spielvogel BF, Yousef JA, Burnham B, Hall IH: Synthesis and antineoplastic activity of some cyano-, carboxy-, carbomethoxy-, and carbamyl-borane adducts of heterocyclic amines. J Pharm Sci 80: 1133-1140, 1991.
8. Geran RJ, Greenburg NH, MacDonald MM, Schumacher AM, Abbott BJ: Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Cherno Rep 3: 9-11, 1972.
9. Leibovitz AL, Stinson JC, McComb WB III, McCoy CE, Mazur KC, Mabry ND: Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 36: 4562-4569, 1976.
10. Liao LL, Kupchan SM, Horwitz SB: Mode of action of the antitumor compound bruccatin, an inhibitor of protein synthesis. Mol Pharmacol 12: 167-176, 1976.
11. Cadman E, Heimer R, Benz C: The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. J Biol Chem 256: 1695-1704, 1981.
12. Christopherson RI, Yu ML, Jones ME: An overall radioassay for the first three reactions of de novo pyrimidinesynthesis. Anal Biochem 11: 240-249, 1981.
13. Sawada H, Tatsumi K, Sadada M, Shirakawa S, Nakamura T, Wakisaka G: Effects of neocarzinostatin on DNA synthesis in L1210 cells. Cancer Res 34: 3341-3346, 1974.
14. Eichler DC, Fisher PA, Korn D: Effect of calcium on the recovery distribution of DNA polymerase from cultured human cells. J Biol Chem 252: 4011-4014, 1977.
15. Anderson KM, Mendelson IS, Guzik G: Solubilized DNA-dependent nuclear RNA polymerases from the mammary glands of late-pregnant rats. Biochem Biophys Acta 383: 56-66, 1975.
16. Hall IH, Carlson GL, Abernathy GS, Piantadosi C: Cycloalkanones IV. Antifertility agents. J Med Chem 17: 1253-1257, 1974.
17. Moore EC, Hurlbert RB: Regulation of mammalian deoxyribonucletide biosynthesis by nucleotide or activators and inhibitors. J Biol Chem 241: 4802-4809, 1966.
18. Ho YK, Hakala T, Zakrzewski SF: 5-(1-Adamantyl) pyrimidines as inhibitors of folate metabolism. Cancer Res 32: 1023-1028, 1971.
19. Spassova MK, Russev GC, Goovinsky EV: Some pyrazoles as inhibitors of purine biosynthesis de novo. Biochem Pharmacol 25: 923-924, 1976.
20. Becker JH, Lohr GW: Inosine-5'-phosphate dehydrogenase activity in normal and leukemic blood cells. Klin. Wochenschr 57: 1109-1115, 1979.
21. Kalman SM, Duffield PH, Brzozwki TJ: Purification and properties of a bacterial carbamyl phosphate synthetase. J Biol Chem 241: 1871-1877, 1966.
22. Archibald RM: Determination of citrulline and allontoin and demonstration of citrulline in blood plasma. J Biol Chem 156: 121-142, 1944.
23. Koritz SB, Gohen PP: Colorimetic determination of carbamyl amino acid and related compounds. J Biol Chem 209: 145-150, 1954.
24. Kampf A, Barfknecht RL, Schaffer PJ, Osaki S, Mertes MP: Synthetic inhibitors of Escherichia coli calf thymus and Ehrlich ascites tumor thymidylate synthetase. J Med Chem 19: 903-908, 1976.
25. Maley F, Ochoa S: Enzymatic phosphorylation of deoxycytidylic acid. J Biol Chem 233: 1538-1543, 1958.
26. Lowry OH, Rosebrough J, Farr AL, Randall RJ: Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275, 1951.
27. Bagnara AS, Finch LR: Quantitative extraction and estimation of intracellular nucleotide-triphosphate in Escherichia coli. Anal Biochem 45: 24-34, 1971.
28. Hunting D, Henderson JF: Determination of deoxyribonucleoside triphosphates using DNA polymerase: a critical evaluation. Can J Biochem 59: 723-727, 1982.
29. Suzuki H, Nishimura T, Muto SK Tanaka N: Mechanism of action of macromomycin: DNA strand scission, inhibition of DNA synthesis mitosis. J Antibacteriol 32: 875-883, 1978.
30. Pera JF Sr, Rawlings CJ, Shackleton J, Roberts JJ: Quantitative aspects of the formation and loss of DNA. Biochem Biophy Acta 655: 152-166, 1981.
31. 3 cells by cytotoxic and antitumor sesquiterpine lactones. Biochem. Pharmacol 30: 3005-3007, 1981.
32. Zhao Y, Hall IH, Oswald CB, Yokoi T, Lee KH: Anti-malarial agents III. Mechanism of action of artesunate against Plasmodium berghi infection. Chem Phar Bull 35: 2052-2061, 1987.