Inhibition of DNA synthesis by downregulation of cyclin A but not Skp 2 overexpression in human hepatocellular carcinoma cells

Cancer Letters

Volumn 139, Issue 1, 1999, Pages 1-6

  Chao, Yee ^a   Shih, Yung Luen ^b   Chen, Hsin Ju ^b   Lee, Shou Dong ^a   Huang, Tze Sing ^b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b Cancer Res Div Natl Hlth R ^*  (Taiwan)

Author keywords

Antisense oligonucleotide phosphorothioate (S oligo); Cyclin A; DNA synthesis; Hepatocelluar carcinoma (HCC); Skp 2

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYCLIN A; CYCLIN E; REGULATOR PROTEIN; REPLICATION PROTEIN A; TRANSCRIPTION FACTOR E2F;

ARTICLE; CANCER RECURRENCE; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CYCLIN A; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; S-PHASE KINASE-ASSOCIATED PROTEINS; TUMOR CELLS, CULTURED;

EID: 0032899622     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00352-8     Document Type: Article

References (27)

1. Wang J., Chenivesse X., Henglein B., Brechot C. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature (Lond.). 343:1990;555-557.
2. Walker D.H., Maller J.L. Role of the cyclin A in the dependence of mitosis on completion of DNA replication. Nature (Lond.). 345:1991;314-317.
3. Pagano M., Pepperkok R., Verde F., Ansorge W., Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J. 11:1992;961-971.
4. 2 phases of the cell cycle and associates with cyclin A. Proc. Natl. Acad. Sci. USA. 89:1992;2824-2828.
5. Dutta A., Stillmann B. Cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J. 11:1992;2189-2199.
6. Xiong Y., Zhang H., Beach D. Subunit rearrangement of cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 7:1993;1572-1583.
7. Bandara L., Adamczewski J., Hunter T., La Thangue N. Cyclin A and retinoblastoma gene product complex with a common transcription factor. Nature (Lond.). 352:1991;249-251.
8. Mudryj M., Devoto S., Hiebert S., Hunter T., Pines J., Nevins J. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell. 65:1991;1243-1253.
9. Shirodkar S., Ewen M.E., DeCaprio J., Morgan J., Livingstone D.M., Chittenden T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle regulated manner. Cell. 69:1992;157-166.
10. Chao Y., Shih Y.-L., Chiu J.-H., Chau G.-Y., Lui W.-Y., Yang W.K., Lee S.-D., Huang T.-S. Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma. Cancer Res. 58:1998;985-990.
11. Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell. 82:1995;915-925.
12. Tonkinson J.L., Stein C.A. Antisense oligodeoxynucleotides as clinical therapeutic agents. Cancer Invest. 14:1996;54-65.
13. Maher L.J. III. Prospects for the therapeutic use of antisense oligonucleotides. Cancer Invest. 14:1996;66-82.
14. Chen M.-H., Yang W.K., Whang-Peng J., Lee L.-S., Huang T.-S. Differential inducibilities of GFAP expression, cytostasis and apoptosis in primary cultures of human astrocytic tumors. Apoptosis. 3:1998;171-182.
15. Huang T.-S., Yang W.K., Whang-Peng J. GL331-induced disruption of cyclin B1/CDC 2 complex and inhibition of CDC2 kinase activity. Apoptosis. 1:1996;213-217.
16. Huang T.-S., Shu C.-H., Yang W.K., Whang-Peng J. Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis. Cancer Res. 57:1997;2974-2978.
17. Huang T.-S., Duyster J., Wang J.Y.J. Biological response to phorbol ester determined by alternative G1 pathways. Proc. Natl. Acad. Sci. USA. 92:1995;4793-4797.
18. Meikrantz W., Gisselbrecht S., Tam S.W., Schlegel R. Activation of cyclin A-dependent protein kinases during apoptosis. Proc. Natl. Acad. Sci. USA. 91:1994;3754-3758.
19. Hoang A.T., Cohen K.J., Barrett J.F., Bergstrom D.A., Dang C.V. Participation of cyclin A in Myc-induced apoptosis. Proc. Natl. Acad. Sci. USA. 91:1994;6875-6879.
20. Li C.J., Friedman D.J., Wang C., Metelev V., Pardee A.B. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science. 268:1995;429-431.
21. Volm M., Koomagi R., Mattern J., Stammler G. Cyclin A is associated with an unfavorable outcome in patients with non-small-cell lung carcinomas. Br. J. Cancer. 75:1997;1774-1778.
22. Paterlini P., Flejou J.-F., De Mitri M.S., Pisi E., Franco D., Brechot C. Structure and expression of the cyclin A gene in human primary liver cancer. Correlation with flow cytometric parameters. J. Hepatol. 23:1995;47-52.
23. De Mitri M.S., Pisi E., Brechot C., Paterlini P. Low frequency of allelic loss in the cyclin A gene in human hepatocellular carcinomas: a study based on PCR. Liver. 13:1993;259-261.
24. Lorenz P., Baker B.F., Bennett C.F., Spector D.L. Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies. Mol. Biol. Cell. 9:1998;1007-1023.
25. Hunter T., Pines J. Cyclins and cancer. Cell. 66:1991;1071-1074.
26. Hunter T., Pines J. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell. 79:1994;573-582.
27. Zhou P., Jiang W., Zhang Y., Kahn S.M., Schieren I., Santella R.M., Weinstein I.B. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells. Oncogene. 11:1995;571-580.