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Volumn 40, Issue 1, 1999, Pages 166-176

Alpha-emitting bismuth cyclohexylbenzyl DTPA constructs of recombinant humanized anti-CD33 antibodies: Pharmacokinetics, bioactivity, toxicity and chemistry

Author keywords

particles; 212Bi; 213Bi; CHX A DTPA; HuM195; M195; Monoclonal antibodies

Indexed keywords

BISMUTH DERIVATIVE; MONOCLONAL ANTIBODY M 195; PENTETIC ACID DERIVATIVE;

EID: 0032898445     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (181)

References (58)
  • 1
    • 0027208577 scopus 로고
    • Radioimmunotherapy of B-cell lymphoma with [I-131]anti-B1 (anti-CD20) antibody
    • Kaminski MS, Zasadny KR, Francis IR, et al. Radioimmunotherapy of B-cell lymphoma with [I-131]anti-B1 (anti-CD20) antibody. N Engl J Med. 1993;329: 459-465.
    • (1993) N Engl J Med. , vol.329 , pp. 459-465
    • Kaminski, M.S.1    Zasadny, K.R.2    Francis, I.R.3
  • 2
    • 0024321013 scopus 로고
    • Treatment of refractory non-Hodgkins lymphoma with radiolabeled MB-1 (anti-CD37) antibody
    • Press OW, Early JF, Badjer CC, et al. Treatment of refractory non-Hodgkins lymphoma with radiolabeled MB-1 (anti-CD37) antibody. J Clin Oncol. 1988;7: 1027-1399.
    • (1988) J Clin Oncol. , vol.7 , pp. 1027-1399
    • Press, O.W.1    Early, J.F.2    Badjer, C.C.3
  • 3
    • 0027499283 scopus 로고
    • Dose-escalation trial of M195 labeled with iodine-131 for cytoreduction and marrow ablation in relapsed or refractory myeloid leukemias
    • Schwartz MA, Lovett DR, Redner A, et al. Dose-escalation trial of M195 labeled with iodine-131 for cytoreduction and marrow ablation in relapsed or refractory myeloid leukemias. J Clin Oncol. 1993;11:294-303.
    • (1993) J Clin Oncol. , vol.11 , pp. 294-303
    • Schwartz, M.A.1    Lovett, D.R.2    Redner, A.3
  • 4
    • 0019225877 scopus 로고
    • Radiotoxicity of Se-75 and S-35. Theory and application to a cellular model
    • Kassis AI, Adelstein SJ, Haycock C, Sastry KRS. Radiotoxicity of Se-75 and S-35. Theory and application to a cellular model. Radiat Res. 1980;84:407-425.
    • (1980) Radiat Res. , vol.84 , pp. 407-425
    • Kassis, A.I.1    Adelstein, S.J.2    Haycock, C.3    Sastry, K.R.S.4
  • 5
    • 0030160773 scopus 로고    scopus 로고
    • Enhancement of radiation dose to the nucleus by vesicular internalization of iodine-125 labeled A33 monoclonal antibody
    • Daghighian F, Barendswaard E, Welt S, et al. Enhancement of radiation dose to the nucleus by vesicular internalization of iodine-125 labeled A33 monoclonal antibody. J Nucl Med. 1996;37:1052-1057.
    • (1996) J Nucl Med. , vol.37 , pp. 1052-1057
    • Daghighian, F.1    Barendswaard, E.2    Welt, S.3
  • 6
    • 0344856786 scopus 로고
    • Generator-produced Bi-212 chelated to chemically modified monoclonal antibody for use in radiotherapy
    • Knapp FF, Butler TA, eds. Symposium Series no. 241. Washington, DC: American Chemical Society
    • Gansow OA, Atcher RW, Link DC, et al. Generator-produced Bi-212 chelated to chemically modified monoclonal antibody for use in radiotherapy. In: Knapp FF, Butler TA, eds. Radionuclide Generators: New Systems for Nuclear Medicine Application. Symposium Series no. 241. Washington, DC: American Chemical Society; 1984:215-227.
    • (1984) Radionuclide Generators: New Systems for Nuclear Medicine Application , pp. 215-227
    • Gansow, O.A.1    Atcher, R.W.2    Link, D.C.3
  • 7
    • 0026720658 scopus 로고
    • Cellular kinetics, dosimetry, and radiobiology of α-particle radioimmunotherapy: Induction of apoptosis
    • Macklis RM, Lin JY, Beresford B, Atcher RW, Hines JJ, Humm JL. Cellular kinetics, dosimetry, and radiobiology of α-particle radioimmunotherapy: induction of apoptosis. Radiat Res. 1992;130:220-226.
    • (1992) Radiat Res. , vol.130 , pp. 220-226
    • Macklis, R.M.1    Lin, J.Y.2    Beresford, B.3    Atcher, R.W.4    Hines, J.J.5    Humm, J.L.6
  • 8
    • 0029768882 scopus 로고    scopus 로고
    • Radionuclides and carrier molecules for therapy
    • Zweit J. Radionuclides and carrier molecules for therapy. Phys Med Biol. 1996;41:1905-1914.
    • (1996) Phys Med Biol. , vol.41 , pp. 1905-1914
    • Zweit, J.1
  • 9
    • 0029784810 scopus 로고    scopus 로고
    • Targeted therapy using alpha emitters
    • Vaidyanathan G, Zalutsky MR. Targeted therapy using alpha emitters. Phys Med Biol. 1996;41:1915-1931.
    • (1996) Phys Med Biol. , vol.41 , pp. 1915-1931
    • Vaidyanathan, G.1    Zalutsky, M.R.2
  • 11
    • 0030013280 scopus 로고    scopus 로고
    • Radioimmunotherapy with α-particle emitting radioimmunoconjugates
    • Zalutsky MR, Bigner DD. Radioimmunotherapy with α-particle emitting radioimmunoconjugates. Acta Oncol. 1996;35:373-379.
    • (1996) Acta Oncol. , vol.35 , pp. 373-379
    • Zalutsky, M.R.1    Bigner, D.D.2
  • 12
    • 0020333332 scopus 로고
    • The in vivo fate of a At-211 labeled monoclonal antibody with known specificity in a murinc system
    • Vaughan ATM, Bateman WJ, Fisher DR. The in vivo fate of a At-211 labeled monoclonal antibody with known specificity in a murinc system. Int J Rad Oncol Biol Phys. 1982;8:1943-1946.
    • (1982) Int J Rad Oncol Biol Phys. , vol.8 , pp. 1943-1946
    • Vaughan, A.T.M.1    Bateman, W.J.2    Fisher, D.R.3
  • 13
    • 0001042459 scopus 로고
    • 2 fragments with the α-particle emitting nuclide astatine-211: Preservation of immunoreactivity and in vivo localizing capacity
    • 2 fragments with the α-particle emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. Proc Natl Acad Sci USA. 1989;86:7149-7153.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7149-7153
    • Zalutsky, M.R.1    Garg, P.K.2    Friedman, H.S.3    Bigner, D.D.4
  • 14
    • 0025172844 scopus 로고
    • Iodine-125-NRLU-10 kinetic studies and bismuth-212-NRLU-10 toxicity in LS174T nulticell spheroids
    • Langmuir VK, Atcher RA, Hines JJ, Brechbiel MW. Iodine-125-NRLU-10 kinetic studies and bismuth-212-NRLU-10 toxicity in LS174T nulticell spheroids. J Nucl Med. 1990;31:1527-1533.
    • (1990) J Nucl Med. , vol.31 , pp. 1527-1533
    • Langmuir, V.K.1    Atcher, R.A.2    Hines, J.J.3    Brechbiel, M.W.4
  • 17
    • 0002951119 scopus 로고
    • Potential use of alpha emitting radionuclides in the treatment of cancer
    • Wilbur DS. Potential use of alpha emitting radionuclides in the treatment of cancer. Antibody Immunoconj Radiopharm. 1991;4:85-97.
    • (1991) Antibody Immunoconj Radiopharm. , vol.4 , pp. 85-97
    • Wilbur, D.S.1
  • 18
    • 0023932947 scopus 로고
    • An improved generator for the production of Bi-212 and Bi-212 from Ra-224
    • Atcher RN, Friedman AM, Hines JJ. An improved generator for the production of Bi-212 and Bi-212 from Ra-224. Appl Radiat Isot. 1988;39:283-286.
    • (1988) Appl Radiat Isot. , vol.39 , pp. 283-286
    • Atcher, R.N.1    Friedman, A.M.2    Hines, J.J.3
  • 20
    • 0004237434 scopus 로고    scopus 로고
    • Bismuth labeled antibodies for therapy of leukemias, lymphomas, and carcinomas: Preclinical studies
    • McDevitt MR, Nikula TN, Finn RD, et al. Bismuth labeled antibodies for therapy of leukemias, lymphomas, and carcinomas: preclinical studies [abstract]. Tumor Target. 1996;2:182.
    • (1996) Tumor Target , vol.2 , pp. 182
    • McDevitt, M.R.1    Nikula, T.N.2    Finn, R.D.3
  • 21
    • 0000932011 scopus 로고    scopus 로고
    • Refinements and improvements for Bi-213 production and use as a targeted therapeutic radiopharmaceutical
    • Finn RD, McDevitt MR, Scheinberg DA, et al. Refinements and improvements for Bi-213 production and use as a targeted therapeutic radiopharmaceutical [abstract]. J Labelled Compounds Radiopharm. 1997;40:293.
    • (1997) J Labelled Compounds Radiopharm. , vol.40 , pp. 293
    • Finn, R.D.1    McDevitt, M.R.2    Scheinberg, D.A.3
  • 22
    • 0000281479 scopus 로고    scopus 로고
    • Targeted alpha particle therapy for myeloid leukemias: A phase 1 trial of bismuth-213-HuM195 (anti-CD33)
    • Jurcic JG, McDevitt MR, Sgouros G. et al. Targeted alpha particle therapy for myeloid leukemias: a phase 1 trial of bismuth-213-HuM195 (anti-CD33) [abstract]. Blood. 1997;90(suppl):504a.
    • (1997) Blood. , vol.90 , Issue.SUPPL.
    • Jurcic, J.G.1    McDevitt, M.R.2    Sgouros, G.3
  • 23
    • 0002566836 scopus 로고    scopus 로고
    • Bismuth-213 imaging: Pre-clinical characterization of an alpha-particle emitting radionuclide
    • Sgouros G, Humm JL, McDevitt MR, et al. Bismuth-213 imaging: pre-clinical characterization of an alpha-particle emitting radionuclide [Abstract]. J Nucl Med. 1996;37:78P.
    • (1996) J Nucl Med. , vol.37
    • Sgouros, G.1    Humm, J.L.2    McDevitt, M.R.3
  • 24
    • 0027449936 scopus 로고
    • Modeling and dosimetry of monoclonal antibody M195 (anti-CD33) in acute myelogenous leukemia
    • Sgouros G, Graham MC, Divgi CD, Larson SM, Scheinberg DA. Modeling and dosimetry of monoclonal antibody M195 (anti-CD33) in acute myelogenous leukemia. J Nucl Med. 1993;34:422-429.
    • (1993) J Nucl Med. , vol.34 , pp. 422-429
    • Sgouros, G.1    Graham, M.C.2    Divgi, C.D.3    Larson, S.M.4    Scheinberg, D.A.5
  • 25
    • 0000267267 scopus 로고    scopus 로고
    • Pharmacokinetics and dosimetry of an alpha-particle emitter labeled anti-CD33 antibody ([Bi-213]HuM195) in patients with leukemia
    • Sgouros G, Erdi YE, Humm JL, et al. Pharmacokinetics and dosimetry of an alpha-particle emitter labeled anti-CD33 antibody ([Bi-213]HuM195) in patients with leukemia [Abstract]. J Nucl Med. 1997;38:231P.
    • (1997) J Nucl Med. , vol.38
    • Sgouros, G.1    Erdi, Y.E.2    Humm, J.L.3
  • 26
    • 0008190297 scopus 로고    scopus 로고
    • Normal organ dosimetry of leukemia patients treated with HuM195 labeled with the alpha particle emitter bismuth-213
    • Ballangrud AM, Humm JL, McDevitt MR, et al. Normal organ dosimetry of leukemia patients treated with HuM195 labeled with the alpha particle emitter bismuth-213 [abstract]. J Nucl Med. 1998;39:188P.
    • (1998) J Nucl Med. , vol.39
    • Ballangrud, A.M.1    Humm, J.L.2    McDevitt, M.R.3
  • 27
    • 0026020135 scopus 로고
    • A phase i trial of monoclonal antibody M195 in acute myelogenous leukemia: Specific bone marrow targeting and internalization of radionuclide
    • Scheinberg DA, Lowett J, Divgi CD, et al. A phase I trial of monoclonal antibody M195 in acute myelogenous leukemia: specific bone marrow targeting and internalization of radionuclide J Clin Oncol. 1991;9:478-483.
    • (1991) J Clin Oncol. , vol.9 , pp. 478-483
    • Scheinberg, D.A.1    Lowett, J.2    Divgi, C.D.3
  • 28
    • 0028231359 scopus 로고
    • A phase 1B trial of humanized monoclonal antibody M195 (anti-CD33) in myeloid leukemia: Specific targeting without immunogenicity
    • Caron PC, Jurcic JG, Scott AM, et al. A phase 1B trial of humanized monoclonal antibody M195 (anti-CD33) in myeloid leukemia: specific targeting without immunogenicity. Blood. 1994;83:1760-1768.
    • (1994) Blood , vol.83 , pp. 1760-1768
    • Caron, P.C.1    Jurcic, J.G.2    Scott, A.M.3
  • 29
    • 0025740176 scopus 로고
    • An effective chelating agent for labeling of monoclonal antibody with Bi-212 for α-particle mediated radioimmunotherapy
    • Brechbiel MW, Pippin CG, McMurry TJ, et al. An effective chelating agent for labeling of monoclonal antibody with Bi-212 for α-particle mediated radioimmunotherapy. J Chem Soc Chem Commun. 1991:1169-1170.
    • (1991) J Chem Soc Chem Commun. , pp. 1169-1170
    • Brechbiel, M.W.1    Pippin, C.G.2    McMurry, T.J.3
  • 30
    • 37049066500 scopus 로고
    • Synthesis of C-functionalized trans-cyclohexyldiethylenetriaminepentaacetic acids for labeling of monoclonal antibodies with the bismuth-212 α-particle emitter
    • Brechbiel MW, Gansow OA. Synthesis of C-functionalized trans-cyclohexyldiethylenetriaminepentaacetic acids for labeling of monoclonal antibodies with the bismuth-212 α-particle emitter. J Chem Soc Perkin Trans. 1992;1173-1178.
    • (1992) J Chem Soc Perkin Trans. , pp. 1173-1178
    • Brechbiel, M.W.1    Gansow, O.A.2
  • 31
    • 0027425984 scopus 로고
    • Pharmacokinetics and bioactivity of 1,4,7,10-tetra-azacyclododecane N,N′,N″,N‴-tetraacetic acid (DOTA)-bismuth-conjugated anti-Tac antibody for α-emitter (Bi-212) therapy
    • Junghans RP, Dobbs D, Brechbiel MW, et al. Pharmacokinetics and bioactivity of 1,4,7,10-tetra-azacyclododecane N,N′,N″,N‴-tetraacetic acid (DOTA)-bismuth-conjugated anti-Tac antibody for α-emitter (Bi-212) therapy. Cancer Res. 1993;53:5683-5689.
    • (1993) Cancer Res. , vol.53 , pp. 5683-5689
    • Junghans, R.P.1    Dobbs, D.2    Brechbiel, M.W.3
  • 32
    • 0027092901 scopus 로고
    • Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies
    • Caron PC, Co MS, Bull MK, Avdalovic NM, Queen C, Scheinberg DA. Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies. Cancer Res. 1992;52:6761-6767.
    • (1992) Cancer Res. , vol.52 , pp. 6761-6767
    • Caron, P.C.1    Co, M.S.2    Bull, M.K.3    Avdalovic, N.M.4    Queen, C.5    Scheinberg, D.A.6
  • 34
    • 0024509637 scopus 로고
    • Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195
    • Tanimoto M, Scheinberg DA, Cordon-Cardo C, Huie D, Clarkson BD, Old LJ. Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195. Leukemia. 1989;3:339-348.
    • (1989) Leukemia. , vol.3 , pp. 339-348
    • Tanimoto, M.1    Scheinberg, D.A.2    Cordon-Cardo, C.3    Huie, D.4    Clarkson, B.D.5    Old, L.J.6
  • 37
    • 0027434029 scopus 로고
    • Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody
    • Co MS, Scheinberg DA, Avdalovic NM, et al. Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody. Mol Immunol. 1993;30:1361-1367.
    • (1993) Mol Immunol. , vol.30 , pp. 1361-1367
    • Co, M.S.1    Scheinberg, D.A.2    Avdalovic, N.M.3
  • 39
    • 0025242732 scopus 로고
    • Radiometal labeling of immunoproteins: Covalent linkage of 2-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid ligands to immunoglobulin
    • Mirzadeh S, Brechbiel MW, Atcher RW, Gansow OA. Radiometal labeling of immunoproteins: covalent linkage of 2-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid ligands to immunoglobulin. Bioconjug Chem. 1990; 1:59-65.
    • (1990) Bioconjug Chem. , vol.1 , pp. 59-65
    • Mirzadeh, S.1    Brechbiel, M.W.2    Atcher, R.W.3    Gansow, O.A.4
  • 40
    • 0026889408 scopus 로고
    • Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates
    • Pippin CG, Parker TA, McMurry TJ, Brechbiel MW. Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates. Bioconjug Chem. 1992;3:342-345.
    • (1992) Bioconjug Chem. , vol.3 , pp. 342-345
    • Pippin, C.G.1    Parker, T.A.2    McMurry, T.J.3    Brechbiel, M.W.4
  • 43
    • 0344357896 scopus 로고
    • Methods for the production of Ac-225 and Bi-213 for alpha immunotherapy
    • Karlsruhe, Germany: Joint Research Centre
    • Van Geel JNC. Methods for the production of Ac-225 and Bi-213 for alpha immunotherapy. ITU Annual Report 1995-(EUR 16368)-Basic Actinide Research. Karlsruhe, Germany: Joint Research Centre; 1995:55-56.
    • (1995) ITU Annual Report 1995-(EUR 16368)-basic Actinide Research , pp. 55-56
    • Van Geel, J.N.C.1
  • 45
    • 0043222865 scopus 로고
    • Raman laser spectroscopic studies of bismuth(III) halide complexes in aqueous solutions
    • Spivakov BY, Stoyanov ES, Gribov LA, Zolotov YA. Raman laser spectroscopic studies of bismuth(III) halide complexes in aqueous solutions. J Inorg Nucl Chem. 1979;14:453-455.
    • (1979) J Inorg Nucl Chem. , vol.14 , pp. 453-455
    • Spivakov, B.Y.1    Stoyanov, E.S.2    Gribov, L.A.3    Zolotov, Y.A.4
  • 46
    • 0028115495 scopus 로고
    • Affinity thin-layer chromatography test of the immunoreactive fraction of radiolabeled antibodies
    • Zamora PO, Sass K, Cardillo AS, et al. Affinity thin-layer chromatography test of the immunoreactive fraction of radiolabeled antibodies. BioTechniques. 1994;16: 306-311.
    • (1994) BioTechniques. , vol.16 , pp. 306-311
    • Zamora, P.O.1    Sass, K.2    Cardillo, A.S.3
  • 47
    • 0342906803 scopus 로고
    • Recovery of Bi-213 from an Ac-225 cow: Application to the radiolabeling of antibodies with Bi-213
    • Emran AM, ed. New York, NY: Plenum Press
    • Pippin CG, Gansow OA, Bechbiel MW, et al. Recovery of Bi-213 from an Ac-225 cow: application to the radiolabeling of antibodies with Bi-213. In: Emran AM, ed. Chemists' View of Imaging Centers. New York, NY: Plenum Press; 1995:315-322.
    • (1995) Chemists' View of Imaging Centers , pp. 315-322
    • Pippin, C.G.1    Gansow, O.A.2    Bechbiel, M.W.3
  • 48
    • 0343385815 scopus 로고
    • 4 solutions: Isolation of Ac-227 from Pa-231 and Ac-227 daughters
    • 4 solutions: isolation of Ac-227 from Pa-231 and Ac-227 daughters. J Chromatog. 1964;16:538-540.
    • (1964) J Chromatog. , vol.16 , pp. 538-540
    • Nelson, F.1
  • 49
    • 0029146320 scopus 로고
    • Impact of the high tyrosine fraction in complementarity regions: Measured and predicted effects of radioiodination on IgG immunoreactivity
    • Nikula TK, Bocchia M, Curcio MJ, et al. Impact of the high tyrosine fraction in complementarity regions: measured and predicted effects of radioiodination on IgG immunoreactivity. Mol Immunol. 1995;32:865-872.
    • (1995) Mol Immunol. , vol.32 , pp. 865-872
    • Nikula, T.K.1    Bocchia, M.2    Curcio, M.J.3
  • 50
    • 0024789205 scopus 로고
    • Kinetics of indium-111 chloride in chronic myelogenous leukemia
    • Yamauchi K, Suzuki Y, Nagao T, Arimori S. Kinetics of indium-111 chloride in chronic myelogenous leukemia. Nucl Med Commun. 1989;10:817-826.
    • (1989) Nucl Med Commun. , vol.10 , pp. 817-826
    • Yamauchi, K.1    Suzuki, Y.2    Nagao, T.3    Arimori, S.4
  • 51
    • 0000795358 scopus 로고
    • Metabolic characteristics within a chemical family
    • Durbin PW. Metabolic characteristics within a chemical family. Health Phys. 1960;2:225-238.
    • (1960) Health Phys. , vol.2 , pp. 225-238
    • Durbin, P.W.1
  • 52
    • 0020026251 scopus 로고
    • Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies
    • Scheinberg DA, Strand M, Gansow OA. Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies. Science. 1982;215:1511-1513.
    • (1982) Science. , vol.215 , pp. 1511-1513
    • Scheinberg, D.A.1    Strand, M.2    Gansow, O.A.3
  • 53
    • 44949283598 scopus 로고
    • Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelales
    • Gansow OA. Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelales. Nucl Med Biol. 1991;18:369-381.
    • (1991) Nucl Med Biol. , vol.18 , pp. 369-381
    • Gansow, O.A.1
  • 54
    • 0038991670 scopus 로고
    • Lead and bismuth complexes of functionalized DTPA ligands and of the polyazacycloalkane-N-acetic acid DOTA. Utility for radioimmunoimaging and radioimmunotherapy
    • Gansow OA, Brechbiel MW, Pippin CG, et al. Lead and bismuth complexes of functionalized DTPA ligands and of the polyazacycloalkane-N-acetic acid DOTA. Utility for radioimmunoimaging and radioimmunotherapy. Antibody Immunoconjug Radiopharm. 1991;4:413-425.
    • (1991) Antibody Immunoconjug Radiopharm. , vol.4 , pp. 413-425
    • Gansow, O.A.1    Brechbiel, M.W.2    Pippin, C.G.3
  • 55
    • 12344290647 scopus 로고
    • Radiolabeled anti-CD33 monoclonal antibody M195 for myeloid leukemias
    • Jurcic JG, Caron PC, Nikula TK, et al. Radiolabeled anti-CD33 monoclonal antibody M195 for myeloid leukemias. Cancer Res. 1995;55(suppl):5908s-5910s.
    • (1995) Cancer Res. , vol.55 , Issue.SUPPL.
    • Jurcic, J.G.1    Caron, P.C.2    Nikula, T.K.3
  • 57
    • 0011736580 scopus 로고
    • Bismuth-212-labeled anti-Tac monoclonal antibody: α-particle-emitting radionuclides as modalities for radioimmunotherapy
    • Kozak RW, Atcher RW, Gansow OA, Friedman AM, Hines JJ, Waldmann TA. Bismuth-212-labeled anti-Tac monoclonal antibody: α-particle-emitting radionuclides as modalities for radioimmunotherapy. Proc Natl Acad Sci USA. 1986;83: 474-478.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 474-478
    • Kozak, R.W.1    Atcher, R.W.2    Gansow, O.A.3    Friedman, A.M.4    Hines, J.J.5    Waldmann, T.A.6


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