Adrenal responsiveness and the timing of parturition in hypothalamo-pituitary disconnected ovine foetuses with and without constant adrenocorticotrophin infusion

Journal of Neuroendocrinology

Volumn 11, Issue 5, 1999, Pages 343-349

  Poore, K R ^a   Canny, B J ^a   Young, I R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

ACTH; Cortisol; HPD; Ovine foetus; Parturition

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE;

ADRENAL FUNCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELIVERY; FETUS; GESTATIONAL AGE; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LABOR; NONHUMAN; PRIORITY JOURNAL; SHEEP;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; BODY WEIGHT; COSYNTROPIN; FEMALE; FETUS; GESTATIONAL AGE; HYDROCORTISONE; HYPOTHALAMUS; LABOR, OBSTETRIC; ORGAN SIZE; PITUITARY GLAND; PREGNANCY; SHEEP; TIME FACTORS;

EID: 0032898161     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1999.00340.x     Document Type: Article

References (21)

1. Thorburn GD, Liggins GC. Role of the fetal pituitary-adrenal axis and placenta in the initiation of parturition. In: Lamming GE, ed. Marshall's Physiology of Reproduction Pregnancy and Lactation Fetal Physiology. London: Chapman and Hill, 1994: 1,003-1,036.
2. Antolovich GC, Clarke IJ, McMillen IC, Perry RA, Robinson PM, Silver M, Young R. Hypothalamo-pituitary disconnection in the fetal sheep. Neuroendocrinolagy 1990; 51: 1-9.
3. Liggins GC, Kennedy PC, Holm LW. Failure of initiation of parturition after electrocoagulation of the pituitary of the fetal lamb. Am J Obstet Gynecol 1967; 98: 1,080-1,086.
4. Liggins GC. Premature parturition after infusion of corticotrophin or cortisol into foetal lambs. J Endocrinol 1968; 42: 323-329.
5. Challis JRG, Brooks AN. Maturation and activation of hypothalamic-pituitary-adrenal function in fetal sheep. Endoc Rev 1989; 10: 182-204.
6. Poore KR, Young IR, Canny BJ, Thorburn GD. Studies on the role of adrenocorticotropin (ACTH) in the regulation of adrenal responsiveness and the timing of parturition in the ovine fetus. J Endocrinol 1998; 156: 161-171.
7. Antolovich GC, McMillen IC, Robinson PM, Silver M, Young IR, Perry RA. The effect of hypothalamo-pituitary disconnection on the functional and morphologic development of the pituitary-adrenal axis in the fetal sheep in the last third of gestation. Neuroendocrinotogy 1991; 54:254-261.
8. Deayton JM, Young IR, Hollingworth SA, White A, Crosby SR, Thorburn GD. Effect of late hypothalamo-pituitary disconnection on the development of the HPA axis in the ovine fetus and the initiation of parturition. J Neuroendocrinol 1994; 6: 25-31.
9. Ozolins IZ, Young IR, McMillen IC. Effect of cortisol infusion on basal and corticotropin-releasing factor (CRF)-stimulated plasma ACTH con-centrations in the sheep fetus after surgical isolation of the pituitary. Endocrinology 1990; 127: 1,833-1,840.
10. Ross JT, Phillips ID, Owens JA, McMillen IC. Cortisol differentially regulates pituitary-adrenal function in the sheep fetus after disconnection of the hypothalamus and pituitary. J Neuroendocrinol 1997; 9: 663-668.
11. (1-39), adrenal growth and steroidogenesis in the sheep fetus after disconnection of the hypothalamus and pituitary. J Physiol 1996; 491: 871-879.
12. Ozolins IZ, Young IR, McMillen IC. Surgical disconnection of the hypothalamus from the fetal pituitary abolishes the corticotrophic response to intrauterine hypoglycemia or hypoxemia in the sheep during late gestation. Endocrinology 1992; 130: 2,438-2,445.
13. Canny BJ, Young IR, Velhuis JD. Hypothalamo-pituitary disconnection (HPD) of the late-gestation ovine fetus results in profound changes in cortisol secretion that are not reflected in commensurate changes in ACTH secretion. Endocrinology 1998; 139: 3,210-3,219.
14. McDonald TJ, Nathanielsz PW. Bilateral destruction of the fetal paraventricular nuclei prolongs gestation in sheep. Am J Obstet Gynecol 1991; 165: 764-770.
15. Myers DA, McDonald TJ, Nathanielsz PW. Effect of bilateral lesions of the ovine fetal hypothalamic paraventricular nuclei at 118-122 days of gestation on subsequent adrenocortical sleroidogenic enzyme gene expression. Endocrinology 1992; 131: 305-310.
16. McMillen IC, Phillips ID, Ross JT, Robinson JS, Owens JA. Chronic stress: the key to parturition? Reprod Fertil Dev 1995; 7: 499-507.
17. Engler D, Pham T, Fullerton MJ, Funder JW, Clarke IJ. Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. I: Effect of an audiovisual stimulus and insulin-induced hypoglycemia. Neuroendocrinology 1988; 48: 551-560.
18. Durand P, Cathiard A-M, Saez JM. In vitro maturation of ovine fetal adrenal cells adenylate cyclase: corticotropin-dependent and independent development of the response to corticotropin. Biochem Biophys Res Commun 1982; 106: 8-15.
19. Cloete JHL. Prenatal growth in the merino sheep. Onderstepoort J Vet Sci Animal Ind 1939; 13: 417-558.
20. Durand P, Cathiard A-M, Saez JM. Maturation of the ovine fetal adrenal gland: in vivo and in vitro studies. In: Jaffe RBDell'Acqua S, eds. The Endocrine Physiology of Pregnancy and the Peripartal Period Serono Symposium. New York: Raven Press, 1985: 31-52.
21. Bocking AD, McMillen IC, Harding R, Thorburn GD. Effect of reduced uterine blood flow on fetal and maternal cortisol. J Devel Physiol 1986; 8: 237-245.