Separation of enantiomeric ephedrine and pseudoephedrine - High pressure liquid chromatography and capillary electrophoresis

Journal of Forensic Sciences

Volumn 44, Issue 3, 1999, Pages 470-474

  Iwanicki, Richard M ^a,b   Maier, Kristi ^a,c   Zlotnick, Joel A ^a   Liu, Ray H ^a   Kuo, Tsung Li ^d   Tagliaro, Franco ^e  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Department of State Police   (United States)

^c Murty Pharmaceuticals   (United States)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e UNIVERSITY OF VERONA   (Italy)

Author keywords

Capillary electrophoresis; Chiral column; Enantiomer; Ephedrine; Forensic science; GITC; HPLC; Hydroxypropyl cyclodextrin; L TPC; Pseudoephedrine

Indexed keywords

EPHEDRINE; GLUCOSE DERIVATIVE; ILLICIT DRUG; ISOTHIOCYANIC ACID DERIVATIVE; METHAMPHETAMINE; NON PRESCRIPTION DRUG; PSEUDOEPHEDRINE; TRIFLUOROACETIC ACID;

ARTICLE; CAPILLARY ELECTROPHORESIS; DOPING; DRUG DETERMINATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SUBSTANCE ABUSE;

EID: 0032897477     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs14496j     Document Type: Article

References (12)

1. Noggle FT, Clark CR. Liquid chromatographic analysis of samples containing cocaine local anesthetics and other amines. J Assoc Off Anal Chem 1983;66:131-7.
2. Ely RA, McGrath DC. Lithium-ammonia reduction of ephedrine to methamphetamine: An unusual clandestine synthesis. J Forensic Sci 1990;35:720-3.
3. Noggle FT, DeRuiter J, Clark CR. Liquid chromatographic determination of enantiomeric composition of methamphetamine prepared from ephedrine and pseudoephedrine. Anal Chem 1988;58:1643-8.
4. Andrews KM. Ephedra's role as a precursor in the clandestine manufacture of methamphetamine. J Forensic Sci 1995;40:551-60.
5. Hutchinson K, Andrews KM. The use and availability of ephedra products in the United States. Microgram 1995;28:256-63.
6. Department of Health and Human Services. Notice to All DHHS/NIDA Certified Laboratories, 4 February 1991.
7. Scarcella D, Tagliaro F, Turrina S, Manetto G, Nakahara Y, Smith FP, et al. Optimization of a simple method for the chiral separation of phenethylamines of forensic interest based on cyclodextrin complexation capillary electrophoresis and its preliminary application to the analysis of human urine and hair. Forensic Sci Int 1997;89:33-46.
8. Hayes SM, Liu RH, Pillion DJ, Baker S, Ho MO. Enantiomeric composition analysis of amphetamine and methamphetamine by chiral phase high-performance liquid chromatography-mass spectrometry. J Liq Chromatogr 1987;398:239-46.
9. Noggle FT, Clark CR. Resolution of some enantiomeric amines of forensic interest by high-pressure liquid chromatography. J Forensic Sci 1986;31:732-42.
10. Liu J[R]H, Ku WW. Determination of enantiomeric N-trifluoroacetyl-l-prolyl chloride amphetamine derivatives by capillary gas-liquid chromatography/mass spectrometry with chiral and achiral stationary phases. Anal Chem 1981;53:2180-7.
11. Liu J[R]H, Ku WW, Tsay JT, Fitzgerald MP, Kirn S. Approaches to drug sample differentiation. III: A comparative study of the use of chiral and achiral capillary column gas chromatography/mass spectrometry for the determination of methamphetamine enantiomers and possible impurities. J Forensic Sci 1982;27:39-48.
12. Liu J[R]H, Ku WW, Fitzgerald MP. Separation and characterization of drugs and their enantiomers by capillary column gas-liquid chromatography/mass spectrometry. J Assoc Off Anal Chem 1983;66:1443-6.